Metabolite: h_r

Descriptive name:

H+

Model:

Recon3D

Formula:

H

Charge:

0

Compartment:

r - endoplasmic reticulum

Reactions:

BiGG ID
Name
12HARACHDtr
Transport of 12 Hydroxy Arachidonic Acid, Endoplasmatic Reticulum, Active Transport
12HTACRhr
Oxidation of tacrolimus in hepatocytes
1331TAALThr
Demethylation of 13-O-desmethyl-tacrolimus to 13,31-O-Didesmethyl-tacrolimus in hepatocytes
1331TACRhr
Demethylation of 31-O-desmethyl-tacrolimus to 13,31-O-Didesmethyl-tacrolimus in hepatocytes
13DMThr
Demthylation of tacrolimus to 13-O-desmethyl tacrolimus in hepatocytes
14HMDZALThr
Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes
14HMDZhr
Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes
1513DTACRhr
Demthylation of 13-O-desmethyl tacrolimus to 13,15-O-didesmethyl tacrolimus in hepatocytes
1513DTALThr
Demthylation of 15-O-desmethyl tacrolimus to 13,15-O-didesmethyl tacrolimus in hepatocytes
1531TACRhr
Demethylation of 15-O-desmethyl tacrolimus to 15, 31-O-Didesmethyl-tacrolimus in hepatocytes
1531TALThr
Demethylation of 31-O-desmethyl tacrolimus to 15, 31-O-Didesmethyl-tacrolimus in hepatocytes
15DMThr
Demethylation of tacrolimus to 15-O-desmethyl tacrolimus in hepatocytes
18HARACHDtr
Transport of 18 Hydroxy Arachidonic Acid, Endoplasmatic Reticulum, Active Transport
1HMDGLUChr
Glucuronidation of 1-OH-midazolam in enterocytes
1OHMDZhr
Oxidation of midazolam to 1-OH-midazolam in hepatocytes
2HATVACIDOXDhc
Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes
2HATVLACGLUChr
Glucuronidation of 2-hydroxy-atorvastatin-lactone in hepatocytes
2HATVLACOXDhc
Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes
31DMThr
Demethylation of tacrolimus to 31-O-desmethyl tacrolimus in hepatocytes
35DHPVShc
Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes
35DSMVhep
Formation of 3,5-dihydrodoil simvastatin
3HPVShc
Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes
3OHACMPhr
Oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes
4BHGLZhr
Oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes
4HATVACIDOXDhc
Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes
4HATVLACOXDhc
Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes
4HMDZGLUChr
Glucuronidation of 4-OH-midazolam in enterocytes
4OHMDZhr
Oxidation of midazolam to 4-OH-midazolam in hepatocytes
56DHPVShc
Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes
56EPPVShc
Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes
5OHFVSGLUhc
Glucuronidation of 5-hydroxy-fluvastatin
5OHFVShc
Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes
6AHGLZhr
Oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes
6BHGLZGLChr
Glucuronidation of 6-beta-OH-gliclazide-glucuronide in hepatocytes
6BHGLZhr
Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes
6HMSMVhep
Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin
6HSMVhep
Oxidation of simvastatin to 6-beta-hydroxy simvastatin
6MSMVhep
Oxidation of simvastatin to 6-exomethylene lactone form
6OHFVSGLUhc
Glucuronidation of 6-hydroxy-fluvastatin
6OHFVShc
Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes
7AHGLZhr
Oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes
7BHGLZGLChr
Glucuronidation of 7-beta-OH-gliclazide-glucuronide in hepatocytes
7BHGLZhr
Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes
7HPVShc
Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes
ACMPGLUChr
Glucuronidation of acetaminophen in hepatocytes
AM19CSALThr
Alternative pathway for formation of AM19 from AM1 in hepatocytes
AM19CShr
Oxidation of AM9 to AM19 (cyclosporine) in hepatocytes
AM1ACCShr
Oxidation of AM1c to AM1Ac in hepatocytes (alternative mechanism)
AM1C9CShr
Oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)
AM1CCShr
Oxidation of cyclosporine to AM1c in hepatocytes
AM1CGLChr
Glucuronidation of AM1c in hepatocytes
AM1CSAhr
Oxidation of cyclosporine to AM1 in hepatocytes
AM4N9CShr
Oxidation of AM4N to AM4N9 in hepatocytes
AM9CSAhr
Oxidation of cyclosporine to AM9 in hepatocytes
ATVETHGLUChc
Glucuronidation of atorvastatin to atorvastatin ether glucuronide (G1) in hepatocytes
ATVLACGLCURhc
Glucuronidation of atorvastatin lactone to atorvastain lactone ether glucuronide (G3) in hepatocytes
BMTer_U
B mannosyltransferase, endoplasmic reticulum
C14STRr
C-14 sterol reductase
C3STDH1Pr
C-3 sterol dehydrogenase (4-methylzymosterol)
C3STDH1r
C-3 sterol dehydrogenase (4-methylzymosterol)
C3STKR2r
C-3 sterol keto reductase (zymosterol)
C4STMO1r
C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C4STMO2Pr
C-4 methyl sterol oxidase
C4STMO2r
C-4 methyl sterol oxidase
CBPPer
Carbamoyl phosphate phosphotransferase, endoplasmic reticulum
CE7081tr
Transport of 15(R)-HEPE, Endoplasmatic Reticulum, Active Transport
CH25H
Cholesterol 25-hydroxylase
COKECBESr
Carboxylesterase (cocaine) (er)
CRGLZhr
Oxidation of methyl-hydroxy-gliclazide to carboxy-gliclazide in hepatocytes
CRVS1M24hc
Hydroxylation of cerivastatin-M1 to M24 in hepatocytes
CRVS23M24hc
Demethylation of cerivastatin-M23 to M24 in hepatocytes
CRVSM1hc
Demethylation of cerivastatin to M1 in hepatocytes
CRVSM22hc
Spontaneous conversion of glucuronide to cerivastatin-M22 in hepatocytes
CRVSM23hc
Hydroxylation of cerivastatin to M23 in hepatocytes
CRVSM31hc
Spontaneous conversion of glucuronide to cerivastatin-M31 in hepatocytes
CVM1GLUChc
Glucuronidation of cerivastatin-M1
CVM23GLUChc
Glucuronidation of cerivastatin-M23
DESFVShc
Oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes
DHCR71r
7-dehydrocholesterol reductase
DHCR72r
7-dehydrocholesterol reductase
DOLGPP_Ler
Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
DSPVShc
Oxidation of pravastatin to desacyl pravastatin in hepatocytes
DSREDUCr
Desmosterol Reductase
EPOXTAChr
Formation of epoxy derivative of tacrolimus in hepatocytes
ESTR2r
ESTR2r
ESTRr
ESTRr
FAOXC22C22DCHYr
Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum
FAOXMC10OHMC10r
Fatty acid omega oxidation(MC10-->w-OHMC10)er
FVSGLUChc
Glucuronidation of fluvastatin
FVSTETGLUhc
Glucuronidation of des-isopropyl-dihydro-fluvastatin-tetranor
G6PDH1er
Glucose-6-phosphate dehydrogenase, endoplasmic reticulum
G6PDH2er
Glucose 6 phosphate dehydrogenase endoplasmic reticulum
GLNLASEer
Gluconolactonase, endoplasmic reticulum
GPIDA2er
Glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
GPIDAer
Glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
GPIMTer_U
GlcN-acylPI mannosyltransferase, endoplasmic reticulum
GTACMPhr
Glucuronidation of thiomethyl-acetaminophen conjugate in hepatocytes
GULNDer
Gulonate dehydrogenase, endoplasmic reticulum
H2MTer_U
H2 mannosyltransferase, endoplasmic reticulum
H3MTer_U
H3 mannosyltransferase, endoplasmic reticulum
H5MTer_U
H5 mannosyltransferase, endoplasmic reticulum
H6MTer_U
H6 mannosyltransferase, endoplasmic reticulum
H7MTer_U
H7 mannosyltransferase, endoplasmic reticulum
HDCA24GSr
UDP-Glucuronosyltransferase (UGT) (hyodeoxycholic acid)
HDCA6GSr
UDP-Glucuronosyltransferase (UGT) ER (hyodeoxycholic acid)
HMR_0763
Ceramide Cholinephosphotransferase
HMR_0765
HMR 0765
HMR_1077
Arachidonate 5-Lipoxygenase
HMR_1307
Prostaglandin-Endoperoxide Synthase
HMR_1781
Cholesterol 25-Hydroxylase
HMR_1783
3Beta-Hydroxy-Delta5-Steroid Dehydrogenase
HMR_1785
Cholesterol 25-Hydroxylase
HMR_1897
HMR 1897
HMR_1968
3Beta-Hydroxy-Delta5-Steroid Dehydrogenase
HMR_1971
Steroid Delta-Isomerase
HMR_2571
HMR 2571
HMR_2971
Long-Chain-Fatty-Acid Coenzyme A Ligase
HMR_3684
Steryl-Ester Acylhydrolase
HMR_3685
Steryl-Ester Acylhydrolase
HMR_3686
Steryl-Ester Acylhydrolase
HMR_3687
Steryl-Ester Acylhydrolase
HMR_3688
Steryl-Ester Acylhydrolase
HMR_3689
Steryl-Ester Acylhydrolase
HMR_3690
Steryl-Ester Acylhydrolase
HMR_3692
Steryl-Ester Acylhydrolase
HMR_3694
Steryl-Ester Acylhydrolase
HMR_3695
Steryl-Ester Acylhydrolase
HMR_3696
Steryl-Ester Acylhydrolase
HMR_3698
Steryl-Ester Acylhydrolase
HMR_3699
Steryl-Ester Acylhydrolase
HMR_3701
Steryl-Ester Acylhydrolase
HMR_3703
Steryl-Ester Acylhydrolase
HMR_3704
Steryl-Ester Acylhydrolase
HMR_3705
Steryl-Ester Acylhydrolase
HMR_3706
Steryl-Ester Acylhydrolase
HMR_3707
Steryl-Ester Acylhydrolase
HMR_3708
Steryl-Ester Acylhydrolase
HMR_3709
Steryl-Ester Acylhydrolase
HMR_3711
Steryl-Ester Acylhydrolase
HMR_3712
Steryl-Ester Acylhydrolase
HMR_3713
Steryl-Ester Acylhydrolase
HMR_3714
Steryl-Ester Acylhydrolase
HMR_3715
Steryl-Ester Acylhydrolase
HMR_3716
Steryl-Ester Acylhydrolase
HMR_3717
Steryl-Ester Acylhydrolase
HMR_3718
Steryl-Ester Acylhydrolase
HMR_3719
Steryl-Ester Acylhydrolase
HMR_3721
Steryl-Ester Acylhydrolase
HMR_3722
Steryl-Ester Acylhydrolase
HMR_3723
Steryl-Ester Acylhydrolase
HMR_3724
Steryl-Ester Acylhydrolase
HMR_3725
Steryl-Ester Acylhydrolase
HMR_3726
Steryl-Ester Acylhydrolase
HMR_3727
Steryl-Ester Acylhydrolase
HMR_3728
Steryl-Ester Acylhydrolase
HMR_3729
Steryl-Ester Acylhydrolase
HMR_3734
Steryl-Ester Acylhydrolase
HMR_3736
Steryl-Ester Acylhydrolase
HMR_3737
Steryl-Ester Acylhydrolase
HMR_3738
Steryl-Ester Acylhydrolase
HMR_3739
Steryl-Ester Acylhydrolase
HMR_3740
Steryl-Ester Acylhydrolase
HMR_3741
Steryl-Ester Acylhydrolase
HMR_4124
UDP-D-Glucuronate Carboxy-Lyase (UDP-D-Xylose-Forming)
HMR_6632
NADP-Retinol Dehydrogenase
HMR_6633
Alcohol Dehydrogenase
HMR_6647
Retinal:NAD+ Oxidoreductase
HSD11B1r
11-beta-hydroxysteroid dehydrogenase type 1
HSD11B2r
11-beta-hydroxysteroid dehydrogenase type 2
HSD17B2r
17-beta-hydroxysteroid dehydrogenase
HSD17B3r
Testicular 17-beta-hydroxysteroid dehydrogenase
HSD17B7r
Testicular 17-beta-hydroxysteroid dehydrogenase
HSD17B8r
17-beta-hydroxysteroid dehydrogenase
HSD17B9r
17-beta-hydroxysteroid dehydrogenase (type 7)
HSD3A1r
3 alpha-hydroxysteroid dehydrogenase (type 3)
HSD3A2r
3 alpha-hydroxysteroid dehydrogenase (type 3)
HSD3B11r
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
HSD3B12r
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
HSD3B13r
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
HSD3B2r
3 beta-hydroxysteroid dehydrogenase type 1
HSD3B3r
3 beta-hydroxysteroid dehydrogenase type 1
HSD3B7
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HSD3B7P
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Htr
H transporter, endoplasmic reticulum
IBUP_RCYP2hep
Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
IBUP_RCYP3hep
Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
IBUP_SCYP1hep
Oxidation of S-ibuprofen to 1-hydroxy ibuprofen
IBUP_SCYP2hep
Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
IBUP_SCYP3hep
Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
LEUKTRB4WOHtr
Transport of W-Hydroxyl Leukotriene B4, Intracellular Transport
LNS14DMr
Cytochrome P450 lanosterol 14-alpha-demethylase
LST4EXPhr
Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes
LSTNM1hr
Oxidation of losartan to Losartan-M1 in hepatocytes
LSTNM2hr
Oxidation of losartan to Losartan-M2 in hepatocytes
LSTNM5hr
Oxidation of losartan to Losartan-M5 in hepatocytes
LSTO1r
Lathosterol oxidase
LSTO2r
Lathosterol oxidase
LVSTACOXD6Hhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
LVSTACOXD6MEhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
LVSTOXD3Hhep
Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes
LVSTOXD6Hhep
Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes
LVSTOXD6METhep
Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes
MHGLZhr
Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes
NAPQIhr
NAPQIhr
NDERSVhc
Demethylation of rosuvastatin in hepatocytes
NDP7er
Nucleoside-diphosphatase (UDP), endoplasmic reticulum
NFDACOXDhc
Oxidation of acid metabolite of nifedipine in hepatocytes
P45017A1r
Cytochrome P450 17A1
P45017A2r
Cytochrome P450 17A1
P45017A3r
Cytochrome P450 17A1
P45017A4r
Cytochrome P450 17A1
P4501B1r
Cytochrome P450 1B1
P45021A1r
Steroid 21-hydroxylase
P45021A2r
Steroid 21-hydroxylase
P45039A1r
Oxysterol 7-alpha-hydroxylase
P4503A43r
Cytochrome p450 P450 3A43
P4503A7r
Cytochrome p450 P450 3A7
P45046A1r
Cytochrome P450, family 46, subfamily A, polypeptide 1
P4504B1r
Cytochrome P450 4B1
P4504F121r
Cytochrome p450 4F12/4F2
P4504F122r
Cytochrome p450 4F12/4F2
P4504F123r
Cytochrome p450 4F12/4F2
P4504F81r
Cytochrome p450 4F8
P4507A1r
Cytochrome P450, family 7, subfamily A, polypeptide 1
P4507B11r
Oxysterol 7alpha-hydroxylase
P4507B12r
Oxysterol 7alpha-hydroxylase
P4508B11r
Sterol 12-alpha-hydroxylase
P4508B13r
Sterol 12-alpha-hydroxylase (nadh)
PCHOLPr_hs
Choline phosphatase
PETOHMr_hs
Phosphatidylethanolamine N-methyltransferase
PGLer
6-phosphogluconolactonase, endoplasmic reticulum
PGSr
Prostaglandin G/H synthase
PPAer
Inorganic diphosphatase, endoplasmic reticulum
PTVSThc
Hydrolysis of latone to free acid form of pitavastatin in hepatocytes
PTVSTM13hr
Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes
PVSGLUChc
Glucuronidation of pravastatin in hepatocytes
r0113
UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
r0575
Presqualene Diphosphate:Farnesyl-Diphosphate Farnesyltransferase
r0672
Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
r0783
Lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
r0813
ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
r0924
ATP-binding Cassette (ABC) TCDB:3.A.1.204.5
r1012
Postulated transport reaction
r1014
Postulated transport reaction
r1024
Active transport
r1025
Active transport
r1134
Methylsterol Monooxygenase
r1135
Hydroxysteroid (17-Beta) Dehydrogenase 7
r1146
Biosynthesis of Steroids Enzyme Catalyzed
r1172
EC:3.1.1.13
r1174
EC:3.1.1.13
r1175
Sterol Esterase
r1177
EC:3.1.1.13
r1179
EC:3.1.1.13
r1181
EC:3.1.1.13
r1182
EC:3.1.1.13
r1183
EC:3.1.1.13
r1253
Long-Chain-Fatty-Acid---Coa Ligase
r1380
Delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
RE1441R_1
1-Phosphatidylinositol-4-Phosphate 5-Kinase
RE1901R
Retinal Dehydrogenase
RE1903R
Retinal Dehydrogenase
RE1957R_1
1-Phosphatidylinositol-4-Phosphate 5-Kinase
RE2112R
RE2112R
RE2235R
Unspecific Monooxygenase
RE2636R
RE2636
RE2677R_1
N-Acylsphingosine Galactosyltransferase
RE2814R
RE2814
RE3011R
Alcohol Dehydrogenase
RE3012R
Aldehyde Dehydrogenase (NAD+)
RE3014R
Leukotriene-B4 20-Monooxygenase
RE3015R
Leukotriene-B4 20-Monooxygenase
RE3016R
RE3016
RE3050R
Retinal Dehydrogenase
RE3273R_1
Phospholipase D
RSVhc
Beta-glucuronidase of rosuvastatin-glucuronide in hepatocytes
SGPL12r
Sphingosine-1-phosphate lyase
SMVACIDhep
Beta-glucuronidation of simvastatin-acyl-glucuronide to simvastatin dihydroxy acid form
SQLEr
Squalene epoxidase endoplasmic reticular NADP
SQLSr
Squalene synthase
SR5AR2r
3-oxo-5-alpha-steroid 4-dehydrogenase
SR5ARr
3-oxo-5-alpha-steroid 4-dehydrogenase
STS1r
Steryl-sulfatase
STS2r
Steryl-sulfatase
STS3r
Steryl-sulfatase
STS4r
Steryl-sulfatase
THSACMPhr
Formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes
TMACMPhr
TMACMPhr
TMDM1hr
Tolyl methylhydroxylation of torasemide in hepatocytes
TMDM3hr
Hydroxylation of torasemide to torasemide-M3 in hepatocytes
TMDM5hr
Oxidation of torasemide-M1 to M5 in hepatocytes
TRIPVShc
Formation of triol metabolite of pravastatin in hepatocytes
TSACMGLUChr
Glucuronidation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes
UGCG
Ceramide glucosyltransferase
UROLACer
Uronolactonase, endoplasmic reticulum
WHARACHDtr
Transport of W-Hydroxyl Arachidonic Acid, Intracellular
XYLTer
UDP-xylose:protein xylosyltransferase, endoplasmic reticulum

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Universal metabolite ?

External database links

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Old identifiers

    h[r]

h in other models