Reaction: 14HMDZALThr

Descriptive name:

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + 4ohmdz_r → h2o_r + nadp_r + 14hmdz_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
4ohmdz_r
4-OH-midazolam
1.0
14hmdz_r
1,4-Dihydroxy-midazolam

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1

Genes:

1577_AT1 (CYP3A5)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    14HMDZALThr

14HMDZALThr in other models