12HARACHDtr

Transport of 12 Hydroxy Arachidonic Acid, Endoplasmatic Reticulum, Active Transport

12HTACRhr

Oxidation of tacrolimus in hepatocytes

14HMDZALThr

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

14HMDZhr

Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

18HARACHDtr

Transport of 18 Hydroxy Arachidonic Acid, Endoplasmatic Reticulum, Active Transport

1OHMDZhr

Oxidation of midazolam to 1-OH-midazolam in hepatocytes

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

2HATVLACOXDhc

Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes

35DHPVShc

Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

3HPVShc

Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes

3OHACMPhr

Oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes

4BHGLZhr

Oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

4HATVLACOXDhc

Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes

4OHMDZhr

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

56DHPVShc

Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes

56EPPVShc

Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes

5OHFVShc

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

6AHGLZhr

Oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes

6BHGLZhr

Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

6OHFVShc

Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes

7AHGLZhr

Oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes

7BHGLZhr

Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes

7HPVShc

Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes

ACER11r

Alkaline Ceramidase 1 (Acer1) Or Alkaline Ceramidase 3 (Acer3)

ACER12r

Alkaline Ceramidase 1 (Acer1) Or Alkaline Ceramidase 3 (Acer3)

ACER31r

Alkaline Ceramidase 3 (Acer3)

AM19CSALThr

Alternative pathway for formation of AM19 from AM1 in hepatocytes

AM19CShr

Oxidation of AM9 to AM19 (cyclosporine) in hepatocytes

AM1ACCShr

Oxidation of AM1c to AM1Ac in hepatocytes (alternative mechanism)

AM1ACShr

Formation of AM1A-cyclosporine in hepatocytes

AM1C9CShr

Oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)

AM1CCShr

Oxidation of cyclosporine to AM1c in hepatocytes

AM1CSAhr

Oxidation of cyclosporine to AM1 in hepatocytes

AM4N9CShr

Oxidation of AM4N to AM4N9 in hepatocytes

AM9CSAhr

Oxidation of cyclosporine to AM9 in hepatocytes

ATVACIDhr

Spontaneous conversion of atorvastatin ether glucuronide (G1) to atorvastatin-acid

ATVLAChr

Spontaneous conversion of atorvastain lactone ether glucuronide (G3) to atorvastatin-lactone in hepatocytes

C4STMO1r

C-4 sterol methyl oxidase (4,4-dimethylzymosterol)

CATr

Catalase

CE7081tr

Transport of 15(R)-HEPE, Endoplasmatic Reticulum, Active Transport

CH25H

Cholesterol 25-hydroxylase

COKECBESr

Carboxylesterase (cocaine) (er)

CRGLZhr

Oxidation of methyl-hydroxy-gliclazide to carboxy-gliclazide in hepatocytes

CRVS1M24hc

Hydroxylation of cerivastatin-M1 to M24 in hepatocytes

CRVSM1hr

Beta-glucuronidase of cerivastatin-M1-glucuronide to M1 form

CRVSM23hc

Hydroxylation of cerivastatin to M23 in hepatocytes

CRVSM23hr

Beta-glucuronidase of cerivastatin-M23-glucuronide to M23 form

DOLGPP_Ler

Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)

DOLPH_Ler

Dolichol-phosphate phosphohydrolase, human (liver)

DOLPH_Uer

Dolichol-phosphate phosphohydrolase, human (uterus)

DSPVShc

Oxidation of pravastatin to desacyl pravastatin in hepatocytes

ESTRr

ESTRr

FAOXC16OHC16r

Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

FAOXC22C22DCHYr

Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum

FAOXC22OHC22r

Fatty Acid Omega Oxidation (C22->W-Ohc22), Endoplasmatic Reticulum

FAOXMC10OHMC10r

Fatty acid omega oxidation(MC10-->w-OHMC10)er

FVShc

Hydrolysis of lactone to fluvastatin in hepatocytes

G6PPer

Glucose-6-phosphate phosphatase, edoplasmic reticular

GGT5r

Gamma-glutamyltransferase 5

GLNLASEer

Gluconolactonase, endoplasmic reticulum

GPIDA2er

Glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum

GPIDAer

Glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum

H2Oter

H2O endoplasmic reticulum transport

HMR_1039

Arachidonate 12-Lipoxygenase

HMR_1077

Arachidonate 5-Lipoxygenase

HMR_1307

Prostaglandin-Endoperoxide Synthase

HMR_1315

HMR 1315

HMR_1392

Prostaglandin-Endoperoxide Synthase

HMR_1781

Cholesterol 25-Hydroxylase

HMR_1785

Cholesterol 25-Hydroxylase

HMR_1897

HMR 1897

HMR_2571

HMR 2571

HMR_3684

Steryl-Ester Acylhydrolase

HMR_3685

Steryl-Ester Acylhydrolase

HMR_3686

Steryl-Ester Acylhydrolase

HMR_3687

Steryl-Ester Acylhydrolase

HMR_3688

Steryl-Ester Acylhydrolase

HMR_3689

Steryl-Ester Acylhydrolase

HMR_3690

Steryl-Ester Acylhydrolase

HMR_3692

Steryl-Ester Acylhydrolase

HMR_3694

Steryl-Ester Acylhydrolase

HMR_3695

Steryl-Ester Acylhydrolase

HMR_3696

Steryl-Ester Acylhydrolase

HMR_3698

Steryl-Ester Acylhydrolase

HMR_3699

Steryl-Ester Acylhydrolase

HMR_3701

Steryl-Ester Acylhydrolase

HMR_3703

Steryl-Ester Acylhydrolase

HMR_3704

Steryl-Ester Acylhydrolase

HMR_3705

Steryl-Ester Acylhydrolase

HMR_3706

Steryl-Ester Acylhydrolase

HMR_3707

Steryl-Ester Acylhydrolase

HMR_3708

Steryl-Ester Acylhydrolase

HMR_3709

Steryl-Ester Acylhydrolase

HMR_3710

Steryl-Ester Acylhydrolase

HMR_3711

Steryl-Ester Acylhydrolase

HMR_3712

Steryl-Ester Acylhydrolase

HMR_3713

Steryl-Ester Acylhydrolase

HMR_3714

Steryl-Ester Acylhydrolase

HMR_3715

Steryl-Ester Acylhydrolase

HMR_3716

Steryl-Ester Acylhydrolase

HMR_3717

Steryl-Ester Acylhydrolase

HMR_3718

Steryl-Ester Acylhydrolase

HMR_3719

Steryl-Ester Acylhydrolase

HMR_3721

Steryl-Ester Acylhydrolase

HMR_3722

Steryl-Ester Acylhydrolase

HMR_3723

Steryl-Ester Acylhydrolase

HMR_3724

Steryl-Ester Acylhydrolase

HMR_3725

Steryl-Ester Acylhydrolase

HMR_3726

Steryl-Ester Acylhydrolase

HMR_3727

Steryl-Ester Acylhydrolase

HMR_3728

Steryl-Ester Acylhydrolase

HMR_3729

Steryl-Ester Acylhydrolase

HMR_3734

Steryl-Ester Acylhydrolase

HMR_3736

Steryl-Ester Acylhydrolase

HMR_3737

Steryl-Ester Acylhydrolase

HMR_3738

Steryl-Ester Acylhydrolase

HMR_3739

Steryl-Ester Acylhydrolase

HMR_3740

Steryl-Ester Acylhydrolase

HMR_3741

Steryl-Ester Acylhydrolase

HMR_6647

Retinal:NAD+ Oxidoreductase

HSD17B9r

17-beta-hydroxysteroid dehydrogenase (type 7)

HSD3B2r

3 beta-hydroxysteroid dehydrogenase type 1

HSD3B3r

3 beta-hydroxysteroid dehydrogenase type 1

IBUP_RCYP2hep

Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_RCYP3hep

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP1hep

Oxidation of S-ibuprofen to 1-hydroxy ibuprofen

IBUP_SCYP2hep

Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP3hep

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

LEUKTRB4WOHtr

Transport of W-Hydroxyl Leukotriene B4, Intracellular Transport

LNS14DMr

Cytochrome P450 lanosterol 14-alpha-demethylase

LST4EXPhr

Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes

LSTNM1hr

Oxidation of losartan to Losartan-M1 in hepatocytes

LSTNM2hr

Oxidation of losartan to Losartan-M2 in hepatocytes

LSTNM5hr

Oxidation of losartan to Losartan-M5 in hepatocytes

LSTO1r

Lathosterol oxidase

LSTO2r

Lathosterol oxidase

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

MHGLZhr

Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes

NAPQIhr

NAPQIhr

NDP7er

Nucleoside-diphosphatase (UDP), endoplasmic reticulum

NFDACOXDhc

Oxidation of acid metabolite of nifedipine in hepatocytes

P45017A1r

Cytochrome P450 17A1

P45017A2r

Cytochrome P450 17A1

P45017A3r

Cytochrome P450 17A1

P45017A4r

Cytochrome P450 17A1

P45019A1r

Aromatase

P45019A2r

Aromatase

P4501B1r

Cytochrome P450 1B1

P45021A1r

Steroid 21-hydroxylase

P45021A2r

Steroid 21-hydroxylase

P45039A1r

Oxysterol 7-alpha-hydroxylase

P4503A43r

Cytochrome p450 P450 3A43

P4503A7r

Cytochrome p450 P450 3A7

P45046A1r

Cytochrome P450, family 46, subfamily A, polypeptide 1

P4504B1r

Cytochrome P450 4B1

P4504F121r

Cytochrome p450 4F12/4F2

P4504F122r

Cytochrome p450 4F12/4F2

P4504F123r

Cytochrome p450 4F12/4F2

P4504F81r

Cytochrome p450 4F8

P4507A1r

Cytochrome P450, family 7, subfamily A, polypeptide 1

P4507B11r

Oxysterol 7alpha-hydroxylase

P4507B12r

Oxysterol 7alpha-hydroxylase

P4508B11r

Sterol 12-alpha-hydroxylase

P4508B13r

Sterol 12-alpha-hydroxylase (nadh)

P450LTB4r

Cytochrome p450 leukotriene B4

PCHOLPr_hs

Choline phosphatase

PGLer

6-phosphogluconolactonase, endoplasmic reticulum

PGSr

Prostaglandin G/H synthase

PPAer

Inorganic diphosphatase, endoplasmic reticulum

PTVSThc

Hydrolysis of latone to free acid form of pitavastatin in hepatocytes

PTVSTM3hc

Oxidation of pitavastatin to pitavastatin-M3 in hepatocytes

r0113

UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14

r0813

ATP-binding Cassette (ABC) TCDB:3.A.1.208.9

r0924

ATP-binding Cassette (ABC) TCDB:3.A.1.204.5

r1012

Postulated transport reaction

r1014

Postulated transport reaction

r1024

Active transport

r1025

Active transport

r1134

Methylsterol Monooxygenase

r1146

Biosynthesis of Steroids Enzyme Catalyzed

r1172

EC:3.1.1.13

r1174

EC:3.1.1.13

r1175

Sterol Esterase

r1177

EC:3.1.1.13

r1179

EC:3.1.1.13

r1181

EC:3.1.1.13

r1182

EC:3.1.1.13

r1183

EC:3.1.1.13

RE1448R_1

Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase

RE1901R

Retinal Dehydrogenase

RE1903R

Retinal Dehydrogenase

RE2079R

RE2079

RE2112R

RE2112R

RE2235R

Unspecific Monooxygenase

RE2636R

RE2636

RE2958C

RE2958

RE3012R

Aldehyde Dehydrogenase (NAD+)

RE3014R

Leukotriene-B4 20-Monooxygenase

RE3015R

Leukotriene-B4 20-Monooxygenase

RE3016R

RE3016

RE3017R

RE3017

RE3050R

Retinal Dehydrogenase

RE3268R_1

Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase

RE3273R_1

Phospholipase D

RE3524R

RE3524

RSVhc

Beta-glucuronidase of rosuvastatin-glucuronide in hepatocytes

SBPP1er

Sphingoid base phosphate phosphatase sphinganine 1 phosphatase endoplasmic reticulum

SBPP3er

Sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase), endoplasmic reticulum

SGPL12r

Sphingosine-1-phosphate lyase

SMVACIDhep

Beta-glucuronidation of simvastatin-acyl-glucuronide to simvastatin dihydroxy acid form

SQLEr

Squalene epoxidase endoplasmic reticular NADP

STS1r

Steryl-sulfatase

STS2r

Steryl-sulfatase

STS3r

Steryl-sulfatase

STS4r

Steryl-sulfatase

THSACMPhr

Formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes

TMACMPhr

TMACMPhr

TMDM1hr

Tolyl methylhydroxylation of torasemide in hepatocytes

TMDM3hr

Hydroxylation of torasemide to torasemide-M3 in hepatocytes

TMDM5hr

Oxidation of torasemide-M1 to M5 in hepatocytes

UROLACer

Uronolactonase, endoplasmic reticulum

WHARACHDtr

Transport of W-Hydroxyl Arachidonic Acid, Intracellular