Reaction: 6BHGLZhr

Descriptive name:

Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + glz_r → h2o_r + nadp_r + 6bhglz_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
glz_r
Gliclazide
1.0
6bhglz_r
6-beta-OH-gliclazide

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1558_AT1 or 1565_AT1 or 1557_AT1

Genes:

1558_AT1 (CYP2C8)
1559_AT1 (CYP2C9)
1565_AT1 (CYP2D6)
1557_AT1 (CYP2C19)

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Universal reaction ?

External database links

Old identifiers

    6BHGLZhr

6BHGLZhr in other models