12HTACRhr

Oxidation of tacrolimus in hepatocytes

14HMDZALThr

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

14HMDZhr

Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1OHMDZhr

Oxidation of midazolam to 1-OH-midazolam in hepatocytes

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

2HATVLACOXDhc

Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes

35DHPVShc

Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

3HPVShc

Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes

3OHACMPhr

Oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes

4BHGLZhr

Oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

4HATVLACOXDhc

Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes

4OHMDZhr

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

56DHPVShc

Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes

56EPPVShc

Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes

5OHFVShc

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

6AHGLZhr

Oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes

6BHGLZhr

Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes

6CSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

6OHFVShc

Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes

7AHGLZhr

Oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes

7BHGLZhr

Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes

7HPVShc

Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes

AM19CSALThr

Alternative pathway for formation of AM19 from AM1 in hepatocytes

AM19CShr

Oxidation of AM9 to AM19 (cyclosporine) in hepatocytes

AM1ACCShr

Oxidation of AM1c to AM1Ac in hepatocytes (alternative mechanism)

AM1ACShr

Formation of AM1A-cyclosporine in hepatocytes

AM1C9CShr

Oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)

AM1CCShr

Oxidation of cyclosporine to AM1c in hepatocytes

AM1CSAhr

Oxidation of cyclosporine to AM1 in hepatocytes

AM4N9CShr

Oxidation of AM4N to AM4N9 in hepatocytes

AM9CSAhr

Oxidation of cyclosporine to AM9 in hepatocytes

C4STMO1r

C-4 sterol methyl oxidase (4,4-dimethylzymosterol)

C4STMO2Pr

C-4 methyl sterol oxidase

C4STMO2r

C-4 methyl sterol oxidase

CATr

Catalase

CH25H

Cholesterol 25-hydroxylase

CRGLZhr

Oxidation of methyl-hydroxy-gliclazide to carboxy-gliclazide in hepatocytes

CRVS1M24hc

Hydroxylation of cerivastatin-M1 to M24 in hepatocytes

CRVS23M24hc

Demethylation of cerivastatin-M23 to M24 in hepatocytes

CRVSM1hc

Demethylation of cerivastatin to M1 in hepatocytes

CRVSM23hc

Hydroxylation of cerivastatin to M23 in hepatocytes

DESFVShc

Oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes

EPOXTAChr

Formation of epoxy derivative of tacrolimus in hepatocytes

ESTRr

ESTRr

FAOXC16OHC16r

Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

FAOXC22C22DCHYr

Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum

FAOXC22OHC22r

Fatty Acid Omega Oxidation (C22->W-Ohc22), Endoplasmatic Reticulum

FAOXMC10OHMC10r

Fatty acid omega oxidation(MC10-->w-OHMC10)er

HMR_0986

Arachidonate 15-Lipoxygenase

HMR_1033

Arachidonate:Oxygen 12-Oxidoreductase

HMR_1077

Arachidonate 5-Lipoxygenase

HMR_1305

Prostaglandin-Endoperoxide Synthase

HMR_1781

Cholesterol 25-Hydroxylase

HMR_1785

Cholesterol 25-Hydroxylase

HSD17B9r

17-beta-hydroxysteroid dehydrogenase (type 7)

IBUP_RCYP2hep

Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_RCYP3hep

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP1hep

Oxidation of S-ibuprofen to 1-hydroxy ibuprofen

IBUP_SCYP2hep

Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP3hep

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

LNS14DMr

Cytochrome P450 lanosterol 14-alpha-demethylase

LST4EXPhr

Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes

LSTNM1hr

Oxidation of losartan to Losartan-M1 in hepatocytes

LSTNM2hr

Oxidation of losartan to Losartan-M2 in hepatocytes

LSTNM5hr

Oxidation of losartan to Losartan-M5 in hepatocytes

LSTO1r

Lathosterol oxidase

LSTO2r

Lathosterol oxidase

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

MHGLZhr

Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes

NAPQIhr

NAPQIhr

NDERSVhc

Demethylation of rosuvastatin in hepatocytes

NFDACOXDhc

Oxidation of acid metabolite of nifedipine in hepatocytes

O2ter

O2 transport endoplasmic reticulum

P45017A1r

Cytochrome P450 17A1

P45017A2r

Cytochrome P450 17A1

P45017A3r

Cytochrome P450 17A1

P45017A4r

Cytochrome P450 17A1

P45019A1r

Aromatase

P45019A2r

Aromatase

P4501B1r

Cytochrome P450 1B1

P45021A1r

Steroid 21-hydroxylase

P45021A2r

Steroid 21-hydroxylase

P45039A1r

Oxysterol 7-alpha-hydroxylase

P4503A43r

Cytochrome p450 P450 3A43

P4503A7r

Cytochrome p450 P450 3A7

P45046A1r

Cytochrome P450, family 46, subfamily A, polypeptide 1

P4504B1r

Cytochrome P450 4B1

P4504F121r

Cytochrome p450 4F12/4F2

P4504F122r

Cytochrome p450 4F12/4F2

P4504F123r

Cytochrome p450 4F12/4F2

P4504F81r

Cytochrome p450 4F8

P4507A1r

Cytochrome P450, family 7, subfamily A, polypeptide 1

P4507B11r

Oxysterol 7alpha-hydroxylase

P4507B12r

Oxysterol 7alpha-hydroxylase

P4508B11r

Sterol 12-alpha-hydroxylase

P4508B13r

Sterol 12-alpha-hydroxylase (nadh)

P450LTB4r

Cytochrome p450 leukotriene B4

PGSr

Prostaglandin G/H synthase

PTVSTM13hr

Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes

PTVSTM3hc

Oxidation of pitavastatin to pitavastatin-M3 in hepatocytes

r1134

Methylsterol Monooxygenase

RE2112R

RE2112R

RE2235R

Unspecific Monooxygenase

RE2636R

RE2636

RE3014R

Leukotriene-B4 20-Monooxygenase

RE3015R

Leukotriene-B4 20-Monooxygenase

RE3488R

Prostaglandin-Endoperoxide Synthase

RE3513R

Arachidonate 5-Lipoxygenase

RE3525R

Arachidonate 12-Lipoxygenase

SQLEr

Squalene epoxidase endoplasmic reticular NADP

THSACMPhr

Formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes

TMACMPhr

TMACMPhr

TMDM1hr

Tolyl methylhydroxylation of torasemide in hepatocytes

TMDM3hr

Hydroxylation of torasemide to torasemide-M3 in hepatocytes

TMDM5hr

Oxidation of torasemide-M1 to M5 in hepatocytes

TRIPVShc

Formation of triol metabolite of pravastatin in hepatocytes