Reaction: LVSTOXD6METhep

Descriptive name:

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + lvst_r → 2.0 h2o_r + nadp_r + 6melvst_r

Metabolites:

Stoichiometry
BiGG ID
Name
2.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
lvst_r
Lovastatin lactone form
1.0
6melvst_r
6'-exomethylene-lovastatin lactone form

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1 or 1558_AT1

Genes:

1558_AT1 (CYP2C8)
1577_AT1 (CYP3A5)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    LVSTOXD6METhep

LVSTOXD6METhep in other models