Metabolite: nadph_r


Descriptive name:

Nicotinamide adenine dinucleotide phosphate - reduced

Model:

Recon3D

Formula:

C21H26N7O17P3

Charge:

-4

Compartment:

r - endoplasmic reticulum

Reactions:

BiGG ID
Name
12HTACRhr
Oxidation of tacrolimus in hepatocytes
14HMDZALThr
Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes
14HMDZhr
Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes
1OHMDZhr
Oxidation of midazolam to 1-OH-midazolam in hepatocytes
2HATVACIDOXDhc
Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes
2HATVLACOXDhc
Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes
35DHPVShc
Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes
35DSMVhep
Formation of 3,5-dihydrodoil simvastatin
3HPVShc
Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes
3OHACMPhr
Oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes
4BHGLZhr
Oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes
4HATVACIDOXDhc
Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes
4HATVLACOXDhc
Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes
4OHMDZhr
Oxidation of midazolam to 4-OH-midazolam in hepatocytes
56DHPVShc
Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes
56EPPVShc
Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes
5OHFVShc
Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes
6AHGLZhr
Oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes
6BHGLZhr
Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes
6CSMVhep
Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form
6HMSMVhep
Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin
6HSMVhep
Oxidation of simvastatin to 6-beta-hydroxy simvastatin
6MSMVhep
Oxidation of simvastatin to 6-exomethylene lactone form
6OHFVShc
Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes
7AHGLZhr
Oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes
7BHGLZhr
Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes
7HPVShc
Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes
AM19CSALThr
Alternative pathway for formation of AM19 from AM1 in hepatocytes
AM19CShr
Oxidation of AM9 to AM19 (cyclosporine) in hepatocytes
AM1ACShr
Formation of AM1A-cyclosporine in hepatocytes
AM1C9CShr
Oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)
AM1CCShr
Oxidation of cyclosporine to AM1c in hepatocytes
AM1CSAhr
Oxidation of cyclosporine to AM1 in hepatocytes
AM4N9CShr
Oxidation of AM4N to AM4N9 in hepatocytes
AM9CSAhr
Oxidation of cyclosporine to AM9 in hepatocytes
C14STRr
C-14 sterol reductase
C3STDH1Pr
C-3 sterol dehydrogenase (4-methylzymosterol)
C3STKR2r
C-3 sterol keto reductase (zymosterol)
C4STMO1r
C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C4STMO2Pr
C-4 methyl sterol oxidase
CH25H
Cholesterol 25-hydroxylase
CRVS1M24hc
Hydroxylation of cerivastatin-M1 to M24 in hepatocytes
CRVS23M24hc
Demethylation of cerivastatin-M23 to M24 in hepatocytes
CRVSM1hc
Demethylation of cerivastatin to M1 in hepatocytes
CRVSM23hc
Hydroxylation of cerivastatin to M23 in hepatocytes
DESFVShc
Oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes
DHCR71r
7-dehydrocholesterol reductase
DHCR72r
7-dehydrocholesterol reductase
DSPVShc
Oxidation of pravastatin to desacyl pravastatin in hepatocytes
DSREDUCr
Desmosterol Reductase
ESTRr
ESTRr
FAOXC16OHC16r
Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum
FAOXC22C22DCHYr
Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum
FAOXC22OHC22r
Fatty Acid Omega Oxidation (C22->W-Ohc22), Endoplasmatic Reticulum
FAOXMC10OHMC10r
Fatty acid omega oxidation(MC10-->w-OHMC10)er
G6PDH2er
Glucose 6 phosphate dehydrogenase endoplasmic reticulum
GNDer
Phosphogluconate dehydrogenase, endoplasmic reticulum
GULNDer
Gulonate dehydrogenase, endoplasmic reticulum
HMR_1781
Cholesterol 25-Hydroxylase
HMR_1785
Cholesterol 25-Hydroxylase
HMR_2041
17Beta-Estradiol 17-Dehydrogenase
HMR_6632
NADP-Retinol Dehydrogenase
HSD11B1r
11-beta-hydroxysteroid dehydrogenase type 1
HSD17B3r
Testicular 17-beta-hydroxysteroid dehydrogenase
HSD17B7r
Testicular 17-beta-hydroxysteroid dehydrogenase
HSD17B9r
17-beta-hydroxysteroid dehydrogenase (type 7)
HSD3A2r
3 alpha-hydroxysteroid dehydrogenase (type 3)
HSD3B3r
3 beta-hydroxysteroid dehydrogenase type 1
HSD3B7P
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IBUP_RCYP2hep
Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
IBUP_RCYP3hep
Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
IBUP_SCYP1hep
Oxidation of S-ibuprofen to 1-hydroxy ibuprofen
IBUP_SCYP2hep
Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
IBUP_SCYP3hep
Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
LNS14DMr
Cytochrome P450 lanosterol 14-alpha-demethylase
LSTNM1hr
Oxidation of losartan to Losartan-M1 in hepatocytes
LSTNM2hr
Oxidation of losartan to Losartan-M2 in hepatocytes
LSTNM5hr
Oxidation of losartan to Losartan-M5 in hepatocytes
LSTO1r
Lathosterol oxidase
LSTO2r
Lathosterol oxidase
LVSTACOXD6Hhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
LVSTACOXD6MEhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
LVSTOXD3Hhep
Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes
LVSTOXD6Hhep
Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes
LVSTOXD6METhep
Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes
MHGLZhr
Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes
NADPHtru
NADPH transporter, endoplasmic reticulum
NAPQIhr
NAPQIhr
NDERSVhc
Demethylation of rosuvastatin in hepatocytes
NFDACOXDhc
Oxidation of acid metabolite of nifedipine in hepatocytes
P45017A1r
Cytochrome P450 17A1
P45017A2r
Cytochrome P450 17A1
P45017A3r
Cytochrome P450 17A1
P45017A4r
Cytochrome P450 17A1
P45019A1r
Aromatase
P45019A2r
Aromatase
P4501B1r
Cytochrome P450 1B1
P45021A1r
Steroid 21-hydroxylase
P45021A2r
Steroid 21-hydroxylase
P45039A1r
Oxysterol 7-alpha-hydroxylase
P4503A43r
Cytochrome p450 P450 3A43
P4503A7r
Cytochrome p450 P450 3A7
P45046A1r
Cytochrome P450, family 46, subfamily A, polypeptide 1
P4504B1r
Cytochrome P450 4B1
P4504F121r
Cytochrome p450 4F12/4F2
P4504F122r
Cytochrome p450 4F12/4F2
P4504F123r
Cytochrome p450 4F12/4F2
P4504F81r
Cytochrome p450 4F8
P4507A1r
Cytochrome P450, family 7, subfamily A, polypeptide 1
P4507B11r
Oxysterol 7alpha-hydroxylase
P4507B12r
Oxysterol 7alpha-hydroxylase
P4508B11r
Sterol 12-alpha-hydroxylase
P450LTB4r
Cytochrome p450 leukotriene B4
PGSr
Prostaglandin G/H synthase
PTVSTM13hr
Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes
r0575
Presqualene Diphosphate:Farnesyl-Diphosphate Farnesyltransferase
r0672
Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
r0783
Lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
r1134
Methylsterol Monooxygenase
r1135
Hydroxysteroid (17-Beta) Dehydrogenase 7
r1380
Delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
RE2112R
RE2112R
RE2235R
Unspecific Monooxygenase
RE2636R
RE2636
RE3014R
Leukotriene-B4 20-Monooxygenase
RE3015R
Leukotriene-B4 20-Monooxygenase
SQLEr
Squalene epoxidase endoplasmic reticular NADP
SQLSr
Squalene synthase
SR5AR2r
3-oxo-5-alpha-steroid 4-dehydrogenase
SR5ARr
3-oxo-5-alpha-steroid 4-dehydrogenase
THSACMPhr
Formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes
TMACMPhr
TMACMPhr
TMDM1hr
Tolyl methylhydroxylation of torasemide in hepatocytes
TMDM3hr
Hydroxylation of torasemide to torasemide-M3 in hepatocytes
TRIPVShc
Formation of triol metabolite of pravastatin in hepatocytes

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Universal metabolite ?

External database links

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Old identifiers

    nadph[r]

nadph in other models