12HTACRhr

Oxidation of tacrolimus in hepatocytes

14HMDZALThr

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

14HMDZhr

Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1OHMDZhr

Oxidation of midazolam to 1-OH-midazolam in hepatocytes

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

2HATVLACOXDhc

Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes

35DHPVShc

Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

3HPVShc

Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes

3OHACMPhr

Oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes

4BHGLZhr

Oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

4HATVLACOXDhc

Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes

4OHMDZhr

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

56DHPVShc

Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes

56EPPVShc

Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes

5OHFVShc

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

6AHGLZhr

Oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes

6BHGLZhr

Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes

6CSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

6OHFVShc

Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes

7AHGLZhr

Oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes

7BHGLZhr

Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes

7HPVShc

Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes

AM19CSALThr

Alternative pathway for formation of AM19 from AM1 in hepatocytes

AM19CShr

Oxidation of AM9 to AM19 (cyclosporine) in hepatocytes

AM1ACShr

Formation of AM1A-cyclosporine in hepatocytes

AM1C9CShr

Oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)

AM1CCShr

Oxidation of cyclosporine to AM1c in hepatocytes

AM1CSAhr

Oxidation of cyclosporine to AM1 in hepatocytes

AM4N9CShr

Oxidation of AM4N to AM4N9 in hepatocytes

AM9CSAhr

Oxidation of cyclosporine to AM9 in hepatocytes

C14STRr

C-14 sterol reductase

C3STDH1Pr

C-3 sterol dehydrogenase (4-methylzymosterol)

C3STKR2r

C-3 sterol keto reductase (zymosterol)

C4STMO1r

C-4 sterol methyl oxidase (4,4-dimethylzymosterol)

C4STMO2Pr

C-4 methyl sterol oxidase

CH25H

Cholesterol 25-hydroxylase

CRVS1M24hc

Hydroxylation of cerivastatin-M1 to M24 in hepatocytes

CRVS23M24hc

Demethylation of cerivastatin-M23 to M24 in hepatocytes

CRVSM1hc

Demethylation of cerivastatin to M1 in hepatocytes

CRVSM23hc

Hydroxylation of cerivastatin to M23 in hepatocytes

DESFVShc

Oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes

DHCR71r

7-dehydrocholesterol reductase

DHCR72r

7-dehydrocholesterol reductase

DSPVShc

Oxidation of pravastatin to desacyl pravastatin in hepatocytes

DSREDUCr

Desmosterol Reductase

ESTRr

ESTRr

FAOXC16OHC16r

Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

FAOXC22C22DCHYr

Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum

FAOXC22OHC22r

Fatty Acid Omega Oxidation (C22->W-Ohc22), Endoplasmatic Reticulum

FAOXMC10OHMC10r

Fatty acid omega oxidation(MC10-->w-OHMC10)er

G6PDH2er

Glucose 6 phosphate dehydrogenase endoplasmic reticulum

GNDer

Phosphogluconate dehydrogenase, endoplasmic reticulum

GULNDer

Gulonate dehydrogenase, endoplasmic reticulum

HMR_1781

Cholesterol 25-Hydroxylase

HMR_1785

Cholesterol 25-Hydroxylase

HMR_2041

17Beta-Estradiol 17-Dehydrogenase

HMR_6632

NADP-Retinol Dehydrogenase

HSD11B1r

11-beta-hydroxysteroid dehydrogenase type 1

HSD17B3r

Testicular 17-beta-hydroxysteroid dehydrogenase

HSD17B7r

Testicular 17-beta-hydroxysteroid dehydrogenase

HSD17B9r

17-beta-hydroxysteroid dehydrogenase (type 7)

HSD3A2r

3 alpha-hydroxysteroid dehydrogenase (type 3)

HSD3B3r

3 beta-hydroxysteroid dehydrogenase type 1

HSD3B7P

Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

IBUP_RCYP2hep

Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_RCYP3hep

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP1hep

Oxidation of S-ibuprofen to 1-hydroxy ibuprofen

IBUP_SCYP2hep

Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

IBUP_SCYP3hep

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

LNS14DMr

Cytochrome P450 lanosterol 14-alpha-demethylase

LSTNM1hr

Oxidation of losartan to Losartan-M1 in hepatocytes

LSTNM2hr

Oxidation of losartan to Losartan-M2 in hepatocytes

LSTNM5hr

Oxidation of losartan to Losartan-M5 in hepatocytes

LSTO1r

Lathosterol oxidase

LSTO2r

Lathosterol oxidase

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

MHGLZhr

Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes

NADPHtru

NADPH transporter, endoplasmic reticulum

NAPQIhr

NAPQIhr

NDERSVhc

Demethylation of rosuvastatin in hepatocytes

NFDACOXDhc

Oxidation of acid metabolite of nifedipine in hepatocytes

P45017A1r

Cytochrome P450 17A1

P45017A2r

Cytochrome P450 17A1

P45017A3r

Cytochrome P450 17A1

P45017A4r

Cytochrome P450 17A1

P45019A1r

Aromatase

P45019A2r

Aromatase

P4501B1r

Cytochrome P450 1B1

P45021A1r

Steroid 21-hydroxylase

P45021A2r

Steroid 21-hydroxylase

P45039A1r

Oxysterol 7-alpha-hydroxylase

P4503A43r

Cytochrome p450 P450 3A43

P4503A7r

Cytochrome p450 P450 3A7

P45046A1r

Cytochrome P450, family 46, subfamily A, polypeptide 1

P4504B1r

Cytochrome P450 4B1

P4504F121r

Cytochrome p450 4F12/4F2

P4504F122r

Cytochrome p450 4F12/4F2

P4504F123r

Cytochrome p450 4F12/4F2

P4504F81r

Cytochrome p450 4F8

P4507A1r

Cytochrome P450, family 7, subfamily A, polypeptide 1

P4507B11r

Oxysterol 7alpha-hydroxylase

P4507B12r

Oxysterol 7alpha-hydroxylase

P4508B11r

Sterol 12-alpha-hydroxylase

P450LTB4r

Cytochrome p450 leukotriene B4

PGSr

Prostaglandin G/H synthase

PTVSTM13hr

Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes

r0575

Presqualene Diphosphate:Farnesyl-Diphosphate Farnesyltransferase

r0672

Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181

r0783

Lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72

r1134

Methylsterol Monooxygenase

r1135

Hydroxysteroid (17-Beta) Dehydrogenase 7

r1380

Delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72

RE2112R

RE2112R

RE2235R

Unspecific Monooxygenase

RE2636R

RE2636

RE3014R

Leukotriene-B4 20-Monooxygenase

RE3015R

Leukotriene-B4 20-Monooxygenase

SQLEr

Squalene epoxidase endoplasmic reticular NADP

SQLSr

Squalene synthase

SR5AR2r

3-oxo-5-alpha-steroid 4-dehydrogenase

SR5ARr

3-oxo-5-alpha-steroid 4-dehydrogenase

THSACMPhr

Formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes

TMACMPhr

TMACMPhr

TMDM1hr

Tolyl methylhydroxylation of torasemide in hepatocytes

TMDM3hr

Hydroxylation of torasemide to torasemide-M3 in hepatocytes

TRIPVShc

Formation of triol metabolite of pravastatin in hepatocytes