Reaction: 35DHPVShc

Descriptive name:

Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes

Model:

Recon3D

Reaction:

h_r + 2.0 nadph_r + 2.0 o2_r + pvs_r → 2.0 h2o_r + 2.0 nadp_r + 35dhpvs_r

Metabolites:

Stoichiometry
BiGG ID
Name
2.0
h2o_r
H2O H2O
-1.0
h_r
H+
2.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-2.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-2.0
o2_r
O2 O2
-1.0
pvs_r
Pravastatin
1.0
35dhpvs_r
3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1

Genes:

1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    35DHPVShc

35DHPVShc in other models