P4501B1r

Cytochrome P450 1B1

1545_AT1 or 1576_AT1

P4503A4

Cytochrome P450 3A4

1576_AT1

RE2235R

Unspecific Monooxygenase

1543_AT1 or 1544_AT1 or 1571_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1 or 1548_AT1 or 1588_AT1 or 1559_AT1 or 1580_AT1 or 1555_AT1 or 1577_AT1 or 1549_AT1 or 1551_AT1 or 1572_AT1 or 1562_AT1 or 1573_AT1 or 11283_AT1 or 1545_AT1 or 1553_AT1 or 199974_AT1 or 260293_AT1 or 29785_AT1 or 64816_AT1 or 57834_AT1 or 66002_AT1

HMR_0942

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0946

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0950

HMR 0950

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0954

HMR 0954

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_1838

Lithocholic acid 1beta-hydroxylase

1576_AT1

HMR_2029

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_2457

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

3DHCAS

3-dehydrocholic acid formation

1576_AT1

3DHCDCAS

3-dehydro-chenodehydroxycholic acid formation

1576_AT1

3DHDCAS

3-dehydro-deoxycholic acid formation

1576_AT1

3DHLCAS

3-dehydro-lithocholic acid formation

1576_AT1

CDCA6AH

Chenodeoxycholic acid 6alpha-hydroxylase

1576_AT1

TCDCA6AH

Taurochenodeoxycholic acid 6alpha-hydroxylase

1576_AT1

12HTACRhr

Oxidation of tacrolimus in hepatocytes

1576_AT1 or 1577_AT1

14HMDZALThr

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1576_AT1 or 1577_AT1

14HMDZhr

Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1576_AT1 or 1577_AT1

1OHMDZhr

Oxidation of midazolam to 1-OH-midazolam in hepatocytes

1576_AT1 or 1577_AT1

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

2HATVLACOXDhc

Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes

1576_AT1 or 1577_AT1

35DHPVShc

Conversion of pravastatin to 3-alpha-5-beta-dihydroxy pravastatin in entercoytes

1576_AT1

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

3HPVShc

Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes

1576_AT1 or (4051_AT1 or 8529_AT1)

3HSMVhep

Acid catalyzed rearrangement of 6-beta-hydroxy-simvastatin to 3-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

4HATVLACOXDhc

Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes

1576_AT1 or 1577_AT1

4OHMDZhr

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

1576_AT1 or 1577_AT1

56DHPVShc

Oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes

1576_AT1

56EPPVShc

Oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes

1576_AT1

5OHFVShc

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

1559_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1

6CSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

7HPVShc

Oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes

1576_AT1

AM19CSALThr

Alternative pathway for formation of AM19 from AM1 in hepatocytes

1576_AT1 or 1577_AT1

AM1CSAhr

Oxidation of cyclosporine to AM1 in hepatocytes

1576_AT1 or 1577_AT1

AM9CSAhr

Oxidation of cyclosporine to AM9 in hepatocytes

1576_AT1 or 1577_AT1

CRVS1M24hc

Hydroxylation of cerivastatin-M1 to M24 in hepatocytes

1558_AT1 or 1576_AT1

CRVS23M24hc

Demethylation of cerivastatin-M23 to M24 in hepatocytes

1558_AT1 or 1576_AT1

CRVSM1hc

Demethylation of cerivastatin to M1 in hepatocytes

1558_AT1 or 1576_AT1

DSPVShc

Oxidation of pravastatin to desacyl pravastatin in hepatocytes

1576_AT1

IBUP_RCYP2hep

Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_RCYP3hep

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_SCYP2hep

Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_SCYP3hep

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

LST4EXPhr

Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes

1559_AT1 or 1576_AT1

LSTNM1hr

Oxidation of losartan to Losartan-M1 in hepatocytes

1559_AT1 or 1576_AT1

LSTNM2hr

Oxidation of losartan to Losartan-M2 in hepatocytes

1559_AT1 or 1576_AT1

LSTNM5hr

Oxidation of losartan to Losartan-M5 in hepatocytes

1559_AT1 or 1576_AT1

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

NFDACOXDhc

Oxidation of acid metabolite of nifedipine in hepatocytes

1576_AT1 or 1577_AT1

PTVSTM3hc

Oxidation of pitavastatin to pitavastatin-M3 in hepatocytes

1576_AT1

TRIPVShc

Formation of triol metabolite of pravastatin in hepatocytes

1576_AT1