Reaction: 3HPVShc

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Descriptive name:

Oxidation of pravastatin to 3-hydroxy pravastatin in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + pvs_r → h2o_r + nadp_r + 3hpvs_r

Metabolites:

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Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or (4051_AT1 or 8529_AT1)

Genes:

8529_AT1 (CYP4F2)
4051_AT1 (CYP4F3)
1576_AT1 (CYP3A4)

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