Reaction: 5OHFVShc

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Descriptive name:

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + fvs_r → h2o_r + nadp_r + 5ohfvs_r

Metabolites:

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Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1

Genes:

1576_AT1 (CYP3A4)
1558_AT1 (CYP2C8)
1559_AT1 (CYP2C9)
1565_AT1 (CYP2D6)

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