Gene: 1559_AT1

Descriptive name:

CYP2C9

Model:

Recon3D

Position:

Left: 94938683 – Right: 94989028

Strand:

Plus

Chromosome:

NC_000010.11

Associated reactions:

BiGG ID
Name
Gene reaction rule
P4502C9
Cytochrome P450 2C9
1559_AT1
P4502C92
Cytochrome P450 2C9
1559_AT1 or 1557_AT1
P4502C93
Cytochrome P450 2C9
1559_AT1 or 1557_AT1
P4502C94
Cytochrome P450 2C9
1559_AT1 or 1557_AT1
RE2235R
Unspecific Monooxygenase
1543_AT1 or 1544_AT1 or 1571_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1 or 1548_AT1 or 1588_AT1 or 1559_AT1 or 1580_AT1 or 1555_AT1 or 1577_AT1 or 1549_AT1 or 1551_AT1 or 1572_AT1 or 1562_AT1 or 1573_AT1 or 11283_AT1 or 1545_AT1 or 1553_AT1 or 199974_AT1 or 260293_AT1 or 29785_AT1 or 64816_AT1 or 57834_AT1 or 66002_AT1
HMR_0942
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0946
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0950
HMR 0950
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0954
HMR 0954
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_2029
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_2457
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
5OHFVShc
Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes
1559_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1
6BHGLZhr
Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes
1559_AT1 or 1558_AT1 or 1565_AT1 or 1557_AT1
6OHFVShc
Oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes
1559_AT1
7BHGLZhr
Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes
1557_AT1 or 1558_AT1 or 1559_AT1
DESFVShc
Oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes
1559_AT1
IBUP_RCYP2hep
Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_RCYP3hep
Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_RCYPCARhep
Oxidation of R-3-hydroxy ibuprofen to R-carboxy ibuprofen
1559_AT1
IBUP_SCYP1hep
Oxidation of S-ibuprofen to 1-hydroxy ibuprofen
1559_AT1
IBUP_SCYP2hep
Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_SCYP3hep
Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_SCYPCARhep
Oxidation of S-3-hydroxy ibuprofen to S-carboxy ibuprofen
1559_AT1
LST4EXPhr
Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes
1559_AT1 or 1576_AT1
LSTNM1hr
Oxidation of losartan to Losartan-M1 in hepatocytes
1559_AT1 or 1576_AT1
LSTNM2hr
Oxidation of losartan to Losartan-M2 in hepatocytes
1559_AT1 or 1576_AT1
LSTNM5hr
Oxidation of losartan to Losartan-M5 in hepatocytes
1559_AT1 or 1576_AT1
MHGLZhr
Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes
1559_AT1 or 1562_AT1 or 1557_AT1
NDERSVhc
Demethylation of rosuvastatin in hepatocytes
1559_AT1 or 1557_AT1
PROFVSCOAhc
Beta oxidation (4 cycles) & CYP oxidation of fluvastatin-CoA to des-isoproylpropionic-acid-fluvastatin-CoA in hepatocytes
51_AT1 or 1962_AT1 or 3295_AT1 or 30_AT1 or 1559_AT1
PTVSTM13hr
Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes
1559_AT1 or 1558_AT1
TMDM1hr
Tolyl methylhydroxylation of torasemide in hepatocytes
1559_AT1
TMDM5hr
Oxidation of torasemide-M1 to M5 in hepatocytes
1559_AT1

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External database links

  • Online Mendelian Inheritance in Man: 601130
  • Human Protein Reference Database: 03084
  • NCBI Entrez Gene: 1559
  • CCDS: CCDS7437.1

Provided by MetaNetX (CC BY 4.0)

Old identifiers

    1559.1

Latest BiGG Models publication:

King ZA, Lu JS, Dräger A, Miller PC, Federowicz S, Lerman JA, Ebrahim A, Palsson BO, and Lewis NE. BiGG Models: A platform for integrating, standardizing, and sharing genome-scale models (2016) Nucleic Acids Research 44(D1):D515-D522. doi:10.1093/nar/gkv1049

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