Reaction: IBUP_RCYP3hep

Descriptive name:

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + ibup__R_r → h2o_r + nadp_r + 3hibup__R_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
ibup__R_r
Ibuprofen-R
1.0
3hibup__R_r
3-hydroxy R-ibuprofen

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

Genes:

1557_AT1 (CYP2C19)
1558_AT1 (CYP2C8)
1559_AT1 (CYP2C9)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    IBUP_RCYP3hep

IBUP_RCYP3hep in other models