Gene: 1558_AT1


Descriptive name:

CYP2C8

Model:

Recon3D

Position:

Left: 95037128 – Right: 95069402

Strand:

Minus

Chromosome:

NC_000010.11

Associated reactions:

BiGG ID
Name
Gene reaction rule
P4502C8
Cytochrome P450 2C8
1558_AT1 or 1558_AT2
RE2235R
Unspecific Monooxygenase
1543_AT1 or 1544_AT1 or 1571_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1 or 1548_AT1 or 1588_AT1 or 1559_AT1 or 1580_AT1 or 1555_AT1 or 1577_AT1 or 1549_AT1 or 1551_AT1 or 1572_AT1 or 1562_AT1 or 1573_AT1 or 11283_AT1 or 1545_AT1 or 1553_AT1 or 199974_AT1 or 260293_AT1 or 29785_AT1 or 64816_AT1 or 57834_AT1 or 66002_AT1
HMR_0942
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0946
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0950
HMR 0950
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_0954
HMR 0954
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_2029
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
HMR_2457
Unspecific Monooxygenase
64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1
2HATVACIDOXDhc
Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes
1576_AT1 or 1577_AT1 or 1558_AT1
35DSMVhep
Formation of 3,5-dihydrodoil simvastatin
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
3HSMVhep
Acid catalyzed rearrangement of 6-beta-hydroxy-simvastatin to 3-hydroxy simvastatin
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
4HATVACIDOXDhc
Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes
1576_AT1 or 1577_AT1 or 1558_AT1
5OHFVShc
Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes
1559_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1
6BHGLZhr
Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes
1559_AT1 or 1558_AT1 or 1565_AT1 or 1557_AT1
6CSMVhep
Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
6HMSMVhep
Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
6HSMVhep
Oxidation of simvastatin to 6-beta-hydroxy simvastatin
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
6MSMVhep
Oxidation of simvastatin to 6-exomethylene lactone form
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
7BHGLZhr
Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes
1557_AT1 or 1558_AT1 or 1559_AT1
CRVS1M24hc
Hydroxylation of cerivastatin-M1 to M24 in hepatocytes
1558_AT1 or 1576_AT1
CRVS23M24hc
Demethylation of cerivastatin-M23 to M24 in hepatocytes
1558_AT1 or 1576_AT1
CRVSM1hc
Demethylation of cerivastatin to M1 in hepatocytes
1558_AT1 or 1576_AT1
CRVSM23hc
Hydroxylation of cerivastatin to M23 in hepatocytes
1558_AT1
IBUP_RCYP2hep
Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_RCYP3hep
Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_SCYP2hep
Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
IBUP_SCYP3hep
Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes
1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1
LVSTACOXD6Hhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
1576_AT1 or 1577_AT1 or 1558_AT1
LVSTACOXD6MEhep
Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form
1576_AT1 or 1577_AT1 or 1558_AT1
LVSTOXD3Hhep
Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes
1576_AT1 or 1577_AT1 or 1558_AT1
LVSTOXD6Hhep
Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes
1576_AT1 or 1577_AT1 or 1558_AT1
LVSTOXD6METhep
Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes
1576_AT1 or 1577_AT1 or 1558_AT1
PTVSTM13hr
Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes
1559_AT1 or 1558_AT1

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External database links

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Old identifiers

    1558.1

Latest BiGG Models publication:

King ZA, Lu JS, Dräger A, Miller PC, Federowicz S, Lerman JA, Ebrahim A, Palsson BO, and Lewis NE. BiGG Models: A platform for integrating, standardizing, and sharing genome-scale models (2016) Nucleic Acids Research 44(D1):D515-D522. doi:10.1093/nar/gkv1049


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