P4502C8

Cytochrome P450 2C8

1558_AT1 or 1558_AT2

RE2235R

Unspecific Monooxygenase

1543_AT1 or 1544_AT1 or 1571_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1 or 1548_AT1 or 1588_AT1 or 1559_AT1 or 1580_AT1 or 1555_AT1 or 1577_AT1 or 1549_AT1 or 1551_AT1 or 1572_AT1 or 1562_AT1 or 1573_AT1 or 11283_AT1 or 1545_AT1 or 1553_AT1 or 199974_AT1 or 260293_AT1 or 29785_AT1 or 64816_AT1 or 57834_AT1 or 66002_AT1

HMR_0942

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0946

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0950

HMR 0950

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0954

HMR 0954

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_2029

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_2457

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

3HSMVhep

Acid catalyzed rearrangement of 6-beta-hydroxy-simvastatin to 3-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

5OHFVShc

Oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes

1559_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1

6BHGLZhr

Oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes

1559_AT1 or 1558_AT1 or 1565_AT1 or 1557_AT1

6CSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

7BHGLZhr

Oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes

1557_AT1 or 1558_AT1 or 1559_AT1

CRVS1M24hc

Hydroxylation of cerivastatin-M1 to M24 in hepatocytes

1558_AT1 or 1576_AT1

CRVS23M24hc

Demethylation of cerivastatin-M23 to M24 in hepatocytes

1558_AT1 or 1576_AT1

CRVSM1hc

Demethylation of cerivastatin to M1 in hepatocytes

1558_AT1 or 1576_AT1

CRVSM23hc

Hydroxylation of cerivastatin to M23 in hepatocytes

1558_AT1

IBUP_RCYP2hep

Oxidation of R-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_RCYP3hep

Oxidation of R-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_SCYP2hep

Oxidation of S-ibuprofen to 2-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

IBUP_SCYP3hep

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

PTVSTM13hr

Oxidation of pitavastatin to pitavastatin-M13 in hepatocytes

1559_AT1 or 1558_AT1