Reaction: 6CSMVhep


Descriptive name:

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

Model:

Recon3D

Reaction:

nadph_r + 2.0 o2_r + 6msmv_r → nadp_r + h2o2_r + 6csmv_r

Metabolites:


Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

Genes:

1558_AT1 (CYP2C8)
1565_AT1 (CYP2D6)
1577_AT1 (CYP3A5)
1576_AT1 (CYP3A4)


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Universal reaction ?

External database links

Old identifiers

    6CSMVhep

6CSMVhep in other models