P4503A5

Cytochrome P450 3A5

1577_AT1

RE2235R

Unspecific Monooxygenase

1543_AT1 or 1544_AT1 or 1571_AT1 or 1576_AT1 or 1558_AT1 or 1565_AT1 or 1548_AT1 or 1588_AT1 or 1559_AT1 or 1580_AT1 or 1555_AT1 or 1577_AT1 or 1549_AT1 or 1551_AT1 or 1572_AT1 or 1562_AT1 or 1573_AT1 or 11283_AT1 or 1545_AT1 or 1553_AT1 or 199974_AT1 or 260293_AT1 or 29785_AT1 or 64816_AT1 or 57834_AT1 or 66002_AT1

HMR_0942

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0946

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0950

HMR 0950

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_0954

HMR 0954

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_2029

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

HMR_2457

Unspecific Monooxygenase

64816_AT1 or 1565_AT1 or 1577_AT1 or 1562_AT1 or 1571_AT1 or 1573_AT1 or 1588_AT1 or 1545_AT1 or 1559_AT1 or 1558_AT1 or 1543_AT1 or 1544_AT1 or 1580_AT1 or 113612_AT1 or 1576_AT1 or 1551_AT1 or 1557_AT1 or 29785_AT1 or 57834_AT1 or 199974_AT1 or 66002_AT1 or 260293_AT1 or 11283_AT1 or 1555_AT1 or 1572_AT1 or 1553_AT1 or 1549_AT1 or 1548_AT1

12HTACRhr

Oxidation of tacrolimus in hepatocytes

1576_AT1 or 1577_AT1

14HMDZALThr

Oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1576_AT1 or 1577_AT1

14HMDZhr

Oxidation of 1-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes

1576_AT1 or 1577_AT1

1OHMDZhr

Oxidation of midazolam to 1-OH-midazolam in hepatocytes

1576_AT1 or 1577_AT1

2HATVACIDOXDhc

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

2HATVLACOXDhc

Oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes

1576_AT1 or 1577_AT1

35DSMVhep

Formation of 3,5-dihydrodoil simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

3HSMVhep

Acid catalyzed rearrangement of 6-beta-hydroxy-simvastatin to 3-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

4HATVACIDOXDhc

Oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

4HATVLACOXDhc

Oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes

1576_AT1 or 1577_AT1

4OHMDZhr

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

1576_AT1 or 1577_AT1

6CSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy carboxy simvastatin lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HMSMVhep

Oxidation of 6-exomethylene simvastatin to 6-beta-hydroxy methyl simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6HSMVhep

Oxidation of simvastatin to 6-beta-hydroxy simvastatin

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

6MSMVhep

Oxidation of simvastatin to 6-exomethylene lactone form

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

AM19CSALThr

Alternative pathway for formation of AM19 from AM1 in hepatocytes

1576_AT1 or 1577_AT1

AM1CSAhr

Oxidation of cyclosporine to AM1 in hepatocytes

1576_AT1 or 1577_AT1

AM9CSAhr

Oxidation of cyclosporine to AM9 in hepatocytes

1576_AT1 or 1577_AT1

LVSTACOXD6Hhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTACOXD6MEhep

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD3Hhep

Oxidation of lovastatin to 3-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6Hhep

Oxidation of lovastatin to 6-beta-hydroxy-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

LVSTOXD6METhep

Oxidation of lovastatin to 6-exomethylene-lovastatin in hepatocytes

1576_AT1 or 1577_AT1 or 1558_AT1

NFDACOXDhc

Oxidation of acid metabolite of nifedipine in hepatocytes

1576_AT1 or 1577_AT1