Reaction: 3HSMVhep

Descriptive name:

Acid catalyzed rearrangement of 6-beta-hydroxy-simvastatin to 3-hydroxy simvastatin

Model:

Recon3D

Reaction:

6hsmv_r → 3hsmv_r

Metabolites:

Stoichiometry
BiGG ID
Name
-1.0
6hsmv_r
6'-beta-hydroxy simvastatin lactone
1.0
3hsmv_r
3'-hydroxy-simvastatin-lactone form

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1

Genes:

1558_AT1 (CYP2C8)
1565_AT1 (CYP2D6)
1577_AT1 (CYP3A5)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    3HSMVhep

3HSMVhep in other models