Reaction: 4OHMDZhr

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Descriptive name:

Oxidation of midazolam to 4-OH-midazolam in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + mdz_r → h2o_r + nadp_r + 4ohmdz_r

Metabolites:

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Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1

Genes:

1576_AT1 (CYP3A4)
1577_AT1 (CYP3A5)

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