Reaction: 2HATVACIDOXDhc

Descriptive name:

Oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + atvacid_r → h2o_r + nadp_r + 2hatvacid_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
1.0
2hatvacid_r
2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid
-1.0
atvacid_r
Atorvastatin-acid

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1 or 1558_AT1

Genes:

1576_AT1 (CYP3A4)
1558_AT1 (CYP2C8)
1577_AT1 (CYP3A5)

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Universal reaction ?

External database links

Old identifiers

    2HATVACIDOXDhc

2HATVACIDOXDhc in other models