Oxidation of simvastatin to 6-exomethylene lactone form
h_r + nadph_r + o2_r + smv_r → 2.0 h2o_r + nadp_r + 6msmv_r
(0.0, 1000.0)
0.0
Drug metabolism
1576_AT1 or 1577_AT1 or 1558_AT1 or 1565_AT1
1558_AT1
(CYP2C8)
1565_AT1
(CYP2D6)
1577_AT1
(CYP3A5)
1576_AT1
(CYP3A4)