Reaction: LVSTACOXD6MEhep

Descriptive name:

Hydroxylation of lovastatin-hydroxyacid form to 6-beta-hydroxy-lovastatin-acid form

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + lvstacid_r → 2.0 h2o_r + nadp_r + 6melvacid_r

Metabolites:

Stoichiometry
BiGG ID
Name
2.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
lvstacid_r
Lovastatin-hydroxyacid form
1.0
6melvacid_r
6'-exomethylene-lovastatin-acid form

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1576_AT1 or 1577_AT1 or 1558_AT1

Genes:

1576_AT1 (CYP3A4)
1558_AT1 (CYP2C8)
1577_AT1 (CYP3A5)

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Universal reaction ?

External database links

Old identifiers

    LVSTACOXD6MEhep

LVSTACOXD6MEhep in other models