Reaction: CRVSM1hc

Descriptive name:

Demethylation of cerivastatin to M1 in hepatocytes

Model:

Recon3D

Reaction:

2.0 h_r + nadph_r + o2_r + ahcys_r + crvs_r → nadp_r + amet_r + h2o2_r + crvsm1_r

Metabolites:

Stoichiometry
BiGG ID
Name
-2.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
-1.0
ahcys_r
S-Adenosyl-L-homocysteine
1.0
amet_r
S-Adenosyl-L-methionine
1.0
h2o2_r
Hydrogen peroxide
1.0
crvsm1_r
Cerivastatin-M1
-1.0
crvs_r
Cerivastatin

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1558_AT1 or 1576_AT1

Genes:

1558_AT1 (CYP2C8)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    CRVSM1hc

CRVSM1hc in other models