Reaction: IBUP_SCYP3hep

Descriptive name:

Oxidation of S-ibuprofen to 3-hydroxy-ibuprofen in heaptocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + ibup__S_r → h2o_r + nadp_r + 3hibup__S_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
-1.0
h_r
H+
1.0
nadp_r
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_r
Nicotinamide adenine dinucleotide phosphate - reduced
-1.0
o2_r
O2 O2
1.0
3hibup__S_r
3-hydroxy S-ibuprofen
-1.0
ibup__S_r
Ibuprofen-S

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1558_AT1 or 1576_AT1 or 1557_AT1

Genes:

1557_AT1 (CYP2C19)
1558_AT1 (CYP2C8)
1559_AT1 (CYP2C9)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    IBUP_SCYP3hep

IBUP_SCYP3hep in other models