Reaction: LST4EXPhr

Descriptive name:

Oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes

Model:

Recon3D

Reaction:

o2_r + lstn_r → h2o_r + h_r + lst4exp_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
h2o_r
H2O H2O
1.0
h_r
H+
-1.0
o2_r
O2 O2
-1.0
lstn_r
Losartan
1.0
lst4exp_r
Losartan-E3174/ losartan-M6

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1576_AT1

Genes:

1559_AT1 (CYP2C9)
1576_AT1 (CYP3A4)

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Universal reaction ?

External database links

Old identifiers

    LST4EXPhr

LST4EXPhr in other models