Reaction: PROFVSCOAhc

Descriptive name:

Beta oxidation (4 cycles) & CYP oxidation of fluvastatin-CoA to des-isoproylpropionic-acid-fluvastatin-CoA in hepatocytes

Model:

Recon3D

Reaction:

4.0 coa_x + 4.0 nad_x + nadph_x + 2.0 o2_x + fvscoa_x → 4.0 accoa_x + 2.0 h2o2_x + 2.0 h2o_x + 4.0 h_x + 4.0 nadh_x + nadp_x + profvscoa_x

Metabolites:

Stoichiometry
BiGG ID
Name
4.0
accoa_x
Acetyl-CoA
-4.0
coa_x
Coenzyme A
2.0
h2o2_x
Hydrogen peroxide
2.0
h2o_x
H2O H2O
4.0
h_x
H+
-4.0
nad_x
Nicotinamide adenine dinucleotide
4.0
nadh_x
Nicotinamide adenine dinucleotide - reduced
1.0
nadp_x
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_x
Nicotinamide adenine dinucleotide phosphate - reduced
-2.0
o2_x
O2 O2
-1.0
fvscoa_x
Fluvastatin-CoA form
1.0
profvscoa_x
Des-isoproylpropionic-acid-fluvastatin-CoA

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

51_AT1 or 1962_AT1 or 3295_AT1 or 30_AT1 or 1559_AT1

Genes:

30_AT1 (ACAA1)
1962_AT1 (EHHADH)
51_AT1 (ACOX1)
3295_AT1 (HSD17B4)
1559_AT1 (CYP2C9)

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Universal reaction ?

External database links

Old identifiers

    PROFVSCOAhc

PROFVSCOAhc in other models