Universal reaction: PROFVSCOAhc

Descriptive name:

Beta oxidation (4 cycles) & CYP oxidation of fluvastatin-CoA to des-isoproylpropionic-acid-fluvastatin-CoA in hepatocytes

Reaction:

4.0 coa_x + 4.0 nad_x + nadph_x + 2.0 o2_x + fvscoa_x ⇌ 4.0 accoa_x + 2.0 h2o2_x + 2.0 h2o_x + 4.0 h_x + 4.0 nadh_x + nadp_x + profvscoa_x

Metabolites:

Stoichiometry
BiGG ID
Name
4.0
accoa_x
Acetyl-CoA
-4.0
coa_x
Coenzyme A
2.0
h2o2_x
Hydrogen peroxide
2.0
h2o_x
H2O H2O
4.0
h_x
H+
-4.0
nad_x
Nicotinamide adenine dinucleotide
4.0
nadh_x
Nicotinamide adenine dinucleotide - reduced
1.0
nadp_x
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_x
Nicotinamide adenine dinucleotide phosphate - reduced
-2.0
o2_x
O2 O2
-1.0
fvscoa_x
Fluvastatin-CoA form
1.0
profvscoa_x
Des-isoproylpropionic-acid-fluvastatin-CoA

PROFVSCOAhc in BiGG models:

Organism
Model
Homo sapiens
Recon3D

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External database links

Old identifiers

    PROFVSCOAhc