Reaction: MHGLZhr

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Descriptive name:

Oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes

Model:

Recon3D

Reaction:

h_r + nadph_r + o2_r + glz_r → h2o_r + nadp_r + mhglz_r

Metabolites:

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Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

1559_AT1 or 1562_AT1 or 1557_AT1

Genes:

1562_AT1 (CYP2C18)
1559_AT1 (CYP2C9)
1557_AT1 (CYP2C19)

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