BiGG Models

Metabolite: h2o_c

Descriptive name:

H2O H2O

Model:

Formula:

H2O

Charge:

0

Compartment:

Reactions:

BiGG ID

Name

N1-Methylnicotinamide transport

2-deoxy-D-ribose 1-phosphate phosphorylase

3-sulfinopyruvate hydrolase (spotaneous reaction)

4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

4-Pyridoxal secretion

5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase

L-aminoadipate-semialdehyde dehydrogenase (NADH)

Aminobutyraldehyde dehydrogenase

N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)

N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)

Acid phosphatase (FMN)

Acetol monooxygenase

Acetone monooxygenase

Adenosine deaminase

ADPribose diphosphatase

Adenosylhomocysteinase

Hydrolysis of Alanylalanine

Aldehyde dehydrogenase (phenylacetaldehyde, NAD)

Aldehyde dehydrogenase (acetaldehyde, NAD)

Aldehyde dehydrogenase (acetaldehyde, NADP)

Aldose reductase

Aminomuconate-semialdehyde dehydrogenase

2-aminomuconate reductase

Adenosine monophosphate deaminase

Aminopeptidase (pro-gly)

Apocarboxylase formation

Proteolysis of apoC-Lys-btn

R group coenzyme a ligase

R group coenzyme a ligase

R group coenzyme a ligase

Transport of L-Ascorbate by SVCT1 or SVCT2 transporter

Asparagine synthase (glutamine-hydrolysing)

ATP maintenance requirement

Beta-Aminopropion aldehyde NAD+ oxidoreductase

Betaine-aldehyde dehydrogenase

Biomass function

BIOMASS_cho_producing_1

Biomass for a producing cell line

3',5'-bisphosphate nucleotidase

Biotinidase (biotin)

Biotin transport via sodium symport

Beta-ureidopropionase (D-3-amino-isobutanoate forming)

Carbamoyl-phosphate synthase (glutamine-hydrolysing)

ABC bile acid transporter

Cholesterol efflux (ATP depedent)

Cytosine deaminase

CTP synthase (glutamine)

Vitamin D3 25-hydroxylase

Deoxyadenosine deaminase

Transport of docosapentenoylcoa into peroxisomes.

Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

Fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

Fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)

Dihydropyrimidinase (dihydrothymine)

L-dopachrome isomerase 1

Pyrophasphatase (dephospho-CoA)

Diphosphoglycerate phosphatase

DUTP diphosphatase

Enolase-phosphatase E1

epo_degradation

Epo degradation

epo_translation

Epo translation

17-beta-D-glucuronide transport (ATP-dependent)

ABC transporter

Ethanol monooxygenase

Fatty-acyl-ACP hydrolase

Fatty-acyl-ACP hydrolase

Fatty-acyl-ACP hydrolase

Fatty acyl-CoA peroxisomal transport via ABC system (16:0)

Fatty acyl ACP hydrolase

Fatty-acid-CoA thioesterase (octadecanoate)

Fatty-acid-CoA thioesterase (octadecenoate)

FAD diphosphatase

Fatty-acyl-CoA elongation (n-C18:3CoA)

Fatty-acyl-CoA elongation (n-C20:4CoA)

Fatty-acyl-CoA elongation (n-C20:4CoA)

Fatty-acyl-CoA elongation (n-C20:5CoA)

Fatty acid omega-hydroxylase

Fatty acid omega-hydroxylase

Fatty acid omega-hydroxylase

FAOXOHMC10DC10c

Fatty acid omega oxidation(w-OHMC10-->DC10)c

Fatty acid biosynthesis (n-C10:0ACP)

Fatty-acid biosynthesis (n-C12:0ACP)

Fatty-acid biosynthesis (n-C14:0ACP)

Fatty-acid biosynthesis (n-C16:0ACP)

Fatty-acid biosynthesis (n-C18:0ACP)

Fatty acid biosynthesis (n-C8:0ACP), lumped reaction

Fructose 2 6 bisphosphate 2 phosphatase

Fumarylacetoacetase

Glucosamine-6-phosphate deaminase

Transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine

Glucosylceramidase

Glycolaldehyde dehydrogenase

ABC bile acid transporter

Gamma-glutamyltransferase

Glycine hydroxymethyltransferase, reversible

Transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine

Glutamine phosphoribosyldiphosphate amidotransferase

Glyoxylate oxidase

D-Glyceraldehyde dehydrogenase

Hydrolysis of glycylycine for uptake

Hydrolysis of Glycylleucine in the small intestine for cellular uptake

Hydroxyacylglutathione hydrolase

Hydrolysis of glycylphenylalanine

Hydrolysis of Prolylglycine in the small intestine for cellular uptake

Hydrolysis of glycylsarcosine for uptake

GDP-D-mannose dehydratase

Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)

Glutathione peroxidase and catalase

Glutathione hydralase (periplasmic)

Glutathione transport into mitochondria

Glucuronate 1-phosphate phosphatase

H2O transport via diffusion

H2O endoplasmic reticulum transport

H2O transport, Golgi apparatus

H2O transport, lysosomal

H2O transport nuclear

H2O transport peroxisomal

HCO3 equilibration reaction

H+/K+ gastric/non-gastric P-ATPase and ABC ATPase

3 Hydroxy L kynurenine hydrolase

Hydroxymethylbilane synthase

Hydroxymethylglutaryl CoA synthase

Heme oxygenase 1

Hypoxanthine dehydrogenase

L-Isoleucine oxidase

IMP cyclohydrolase

IMP dehydrogenase

Myo-Inositol:oxygen oxidoreductase

Imidazolonepropionase

B-ketoacyl synthetase (palmitate, n-C16:0)

2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase

Kynurenine 3 monooxygenase

Lactaldehyde dehydrogenase

Lactaldehyde dehydrogenase

Hydrolysis of leucylglycine

Hydrolysis of Leucylleucine in the small intestine for cellular uptake

L-Formylkynurenine hydrolase

Transport of lignocericyl coenzyme A from cytosol to peroxisome.

Lysophospholipase

Leukotriene C4 carboxypeptidase

Leukotriene D4 dipeptidase

2-methylcitrate synthase

5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase

Melatonin:NADP oxidoreductase

Metanephrine secretion via secretory vesicle (ATP driven)

Methionine adenosyltransferase

Inositol-1,2,3,4,5,6-hexaphosphate 2-phosphatase

D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase

D-myo-Inositol 1,3,4-trisphosphate 1-phosphohydrolase

Inositol-1,3-bisphosphate 3-phosphatase

D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase

Inositol-1,4-bisphosphate 4-phosphatase

D-myo-Inositol-1,4-bisphosphate 1-phosphohydrolase

Myo-inositol 1-phosphatase

1D-myo-Inositol 3-phosphate phosphohydrolase

1D-myo-Inositol 4-phosphate phosphohydrolase

Methenyltetrahydrofolate cyclohydrolase

NAD nucleosidase

Nicotinate-mononucleotide adenylyltransferase

Nalpha-(beta-alanyl)-L-histidine hydrolase IR

Nucleoside diphosphatase ADP

Nucleoside-diphosphatase (dCDP)

Nucleoside-diphosphatase (dUDP)

Nicotinamide-nucleotide amidase

Transport of nervonylcoa into peroxisomes

5'-nucleotidase (dUMP)

5'-nucleotidase (UMP)

5'-nucleotidase (dCMP)

5'-nucleotidase (CMP)

5'-nucleotidase (dTMP)

5'-nucleotidase (dAMP)

5'-nucleotidase (AMP)

5'-nucleotidase (dGMP)

5'-nucleotidase (GMP)

Nucleoside triphosphate pyrophosphorylase (gtp)

Nucleoside triphosphate pyrophosphorylase (dctp)

Nucleoside triphosphate pyrophosphorylase (datp)

Nucleoside triphosphate pyrophosphorylase (dttp)

13-cis-4-oxo-retinoic acid formation (oxidation)

4-oxo-retinoic acid formation (oxidation)

Cytochrome P450 2A6

Cytochrome P450 2C19

Cytochrome P450 2C8

Cytochrome P450 2C9

Cytochrome P450 2C9

Cytochrome P450 2C9

Cytochrome P450 2C9

Cytochrome P450 2D6

Cytochrome P450 2E1

Cytochrome P450 2F1

Cytochrome P450 3A5

Phosphatase (pan4p)

Phosphatidylcholine flippase

3',5'-cyclic-nucleotide phosphodiesterase

Phosphatidylethanolamine flippase

Phosphatidylethanolamine flippase

PGAM1_PhosHydro

Phosphoenol pyruvate phosphatase

Phosphatidylglycerol phosphate phosphatase (cho)

Prostaglandin G/H synthase

L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1

Phylloquinone transport

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Phosphatidylinositol-3,4-bisphosphate 3-phosphatase

Phosphatidylinositol-3,5-bisphosphate 3-phosphatase

Phosphatidylinositol-3-phosphate 3-phosphatase

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Phosphatidylinositol 4,5-bisphosphate phospholipase C

Phosphatidylinositol 4-phosphate phospholipase C

Phosphatidylinositol-4-phosphate 4-phosphatase

Phosphatidylinositol phospholipase C

Phospholipase A2

5 diphosphoinositol 1 2 3 4 6 pentakisphosphate diphosphohydrolase

Hydrolase Class RXN R02973

Pantothenate sodium symporter II

Inorganic diphosphatase

Phosphatidic acid phosphatase

Porphobilinogen synthase

Peroxidase (multiple substrates)

Phosphoribosylformylglycinamidine synthase

Transport of pristanoylcoa from cytosol to peroxisomes.

Prostaglandine E1 transport (ATP-dependent)

Prostaglandine E2 transport (ATP-dependent)

Phosphatidylserine flippase

Phosphatidylserine flippase

Phosphoserine phosphatase (L-serine)

Pyridoxamine 5'-phosphate oxidase

Pyridoxal dehydrogenase

Pyridoxamine:oxygen oxidoreductase (deaminating)

Quinolinate Synthase Eukaryotic

Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9

[Acyl-carrier-protein] 4-pantetheine-phosphohydrolase Pantothenate and CoA biosynthesis EC:3.1.4.14

Hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

Alpha-Aminobutyryl histidine hydrolase Urea cycle and metabolism of amino groups EC:3.4.13.3

Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

Aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

(S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

Spontaneous reaction

Spontaneous reaction

ATP-binding Cassette (ABC) TCDB:3.A.1.208.2

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

Active transport

Folylpolyglutamyl synthetase EC:6.3.2.17

Guanosine aminohydrolase EC:3.5.4.15

Amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:3.2.1.33

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

ATP-binding Cassette (ABC) TCDB:3.A.1.208.7

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.208.8

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Retinal dehydrogenase

Retinal dehydrogenase

Retinoic acid hydroxylation (P450)

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Steryl-Sulfatase

Quinine 3-Monooxygenase

4A-Hydroxytetrahydrobiopterin Dehydratase

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Retinyl ester hydrolase (9-cis)

Retinyl ester hydrolase (11-cis)

Riboflavin transport (ATP dependent)

Riboflavin transport out (ATP dependent)

Ribonucleoside-diphosphate reductase (ADP)

Ribonucleoside-diphosphate reductase (GDP)

Ribonucleoside-diphosphate reductase (CDP)

Ribonucleoside-diphosphate reductase (UDP)

Sphinganine 1-phosphate phosphatase

Transport of phytanoylcoa from cytosol to peroxisomes.

S-Formylglutathione hydralase

Spermine oxidase

Sphingomyelinase

Sphingomyelin phosphodiesterase

Sphingomyelin deacylase

Spermidine:(acceptor) oxidoreductase

Transport of Stearoyl-CoA from cytosol to peroxisomes

Steryl-sulfatase

Steryl-sulfatase

Steryl-sulfatase

Steryl-sulfatase

Sulfite oxidase

ABC bile acid transporter

Thiamin pyrophosphatase

Tetrahydrobiopterin-4a-carbinolamine dehydratase

Thiamine exit from the neterocytes

Thiamine monophosphate transport, mitochondrial

Thiamin phosphatase

Thiamine diphosphate transport in via anion antiport, mitochondria

Thiamine-triphosphatase

Tyrosine:dopa oxidase (dopaquinone producing 2)

L-Tyrosine oxidase

UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)

UDPglucuronate uridine-monophosphohydrolase

UDPglucose 6-dehydrogenase

UDP-glucuronate glucuronohydrolase

Uroporphyrinogen-III synthase

B-ureidopropionase

Urea, water cotransport

Efflux of alpha-Tocopherol into the lyphatics in chylomicrons

Xanthine dehydrogenase

Xanthine oxidase

Xanthine oxidase (hypoxanthine)

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Universal metabolite ?

h2o

External database links

InChI Key: XLYOFNOQVPJJNP-UHFFFAOYSA-N
Reactome Compound: 109276, 113518, 113519, 113521, 141343, 1605715, 189422, 2022884, 29356, 351603, 5278291, 5668574, 5693747, 8851517
SEED Compound: cpd00001, cpd15275, cpd27222
CHEBI: CHEBI:10743, CHEBI:13352, CHEBI:13365, CHEBI:13419, CHEBI:15377, CHEBI:16234, CHEBI:27313, CHEBI:29356, CHEBI:29412, CHEBI:30490, CHEBI:33813, CHEBI:42043, CHEBI:42857, CHEBI:43228, CHEBI:44292, CHEBI:44641, CHEBI:44701, CHEBI:44819, CHEBI:5585, CHEBI:5594
Human Metabolome Database: HMDB01039, HMDB02111
KEGG Compound: C00001, C01328
MetaNetX (MNX) Chemical: MNXM2
KEGG Drug: D00001, D06322
BioCyc: META:CPD-15815, META:HYDROXYL-GROUP, META:OH, META:OXONIUM, META:WATER

Provided by MetaNetX (CC BY 4.0)

Old identifiers

h2o_c

h2o in other models