BiGG Models

Metabolite: h2o_c

Descriptive name:

H2O H2O

Model:

Formula:

H2O

Charge:

0

Compartment:

Reactions:

BiGG ID

Name

3'-Phospho-5'-adenylyl sulfate 3'-phosphohydrolase

Transport of Dodecanedioic Acid by FATP

Metabolism (Formation/Degradation) of AsnCysCys

Metabolism (Formation/Degradation) of PheLeu

Leukotriene-B4 20-Monooxygenase

ABC bile acid transporter

Metabolism (Formation/Degradation) of ThrHisHis

Tryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

5'-nucleotidase (GMP)

1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

H2O transport peroxisomal

Conversion of lactone form of 6-exomethylene-lovastatin to acid form

Metabolism (Formation/Degradation) of TrpGlyPhe

Glyoxylate oxidase

Transport of 1-Pentadecanoylglycerophosphoethanolamine (C15:0 Pe)

Adenosine deaminase

Beta-Galactosidase

Acylcoa Hydrolase, Cis, Cis-11, 14-Eicosadienoyl Coenzyme A

Excretion of 6-beta-OH-gliclazide into bile

Glucuronidated bile acid excretion (CDCA-3G)

Retinal dehydrogenase

5- (Methylthio)-2, 3-Dioxopentyl-Phosphate Phosphohydrolase (Isomerizing)

Metabolism (Formation/Degradation) of AspGluPro

Dopamine-O-Quinone Oxidase

Nucleoside-diphosphatase (dCDP)

H2O transport nuclear

Cholate Coenzyme A Ligase

Uptake of acetaminophen-glutathione-conjugate by the hepatocytes

Phosphatidylinositol-3,5-bisphosphate 3-phosphatase

Phosphatidylcholine transporter

Steryl-Sulfatase

Retinoic acid hydroxylation (P450)

PCHOLN19_HSABCt

Transport of 1-NoNADecanoylglycerophosphocholine, Sn1-Lpc (19:0)

Prostaglandin-Endoperoxide Synthase

3 Hydroxy L kynurenine hydrolase

5'-nucleotidase (dCMP)

Hydrolysis of Tetradecadienoyl Coenzyme A to Cis-5, 8-Tetradecadienoic Acid

Hydroxyprogesterone Transport, Active

Metabolism (Formation/Degradation) of AsnPheAsp

Metabolism (Formation/Degradation) of HisLysThr

Metabolism (Formation/Degradation) of PheTrpLeu

Uptake of acetaminophen-glucuronide-conjugate by the hepatocytes

PCHOLN226_HSPLA2

Formation of 1-Docosahexenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16, 19), Sn1-Lpc (22:6) by Phospholipase A2

PCHOL2LINL_HSABCt

Transport of 2-Linoleoylglycerophosphocholine

L-Metanephrine:Oxygen Oxidoreductase (Deaminating) (Flavin-Containing)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Metabolism (Formation/Degradation) of TrpProVal

Metabolism (Formation/Degradation) of TrpGlutyr

Metabolism (Formation/Degradation) of GluThrLys

Efflux of cerivastatin-M24 into bile

Cerivastatin uptake by hepatocytes by active transport

Dihydropyrimidinase (dihydrothymine)

Metabolism (Formation/Degradation) of AlaAsnLeu

Signal Peptidase I

Xanthine oxidase (hypoxanthine)

Steryl-sulfatase

Transport of Pregnenolone Sulfate, Extracellular

Metabolism (Formation/Degradation) of SerGlyGlu

Retinyl ester hydrolase

Ribonucleoside triphosphate reductase GTP

Fatty acid omega-hydroxylase

Sterol 14Alpha-Demethylase

3-Dehydrocholic acid ABC bile acid transporter

Efflux of cysteine-conjugate-acetaminophen into hepatic vein

Metabolism (Formation/Degradation) of TrpValAsp

Steryl-Sulfatase

Phosphatidylglycerol Transport by ABCa3

Metabolism (Formation/Degradation) of HisMetGln

Cytochrome P450 2F1

Metabolism (Formation/Degradation) of PheProArg

Metabolism (Formation/Degradation) of PheSerTrp

Xanthine oxidase

L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1

Metabolism (Formation/Degradation) of ValHisAsn

Steroid 21-Monooxygenase

Metabolism (Formation/Degradation) of CysSerMet

4-trimethylaminobutyraldehyde dehydrogenase

Thyroid peroxidase

Metabolism (Formation/Degradation) of AlaArgCys

V-Type ATPase, H+ Transporting, Lysosomal

Fatty-acyl-CoA elongation (n-C20:4CoA)

Transport of 3Alpha, 7Alpha, 12Alpha-Trihydroxy-5Beta-Cholestanoate, Active Transport

3',5'-bisphosphate nucleotidase

Conversion of 6-beta-hydroxy-methyl simvastatin lactone to acid form

Unspecific Monooxygenase

Transport of 3Alpha-Hydroxy-5Beta-Androstan-17-One, Extracellular

PCHOLLINL_HSABCt

Transport of 1-Linoleoylglycerophosphocholine (Delta 9, 12)

1-alpha hydroxylation of 25-hydroxy vitamin D

Transport of 15-Tetracosenoate, Active Transport

Platelet-activating factor acetylhydrolase

Excretion of gliclazide into bile

Glucuronidated bile acid excretion (DCA-3G)

L-Dehydroascorbate lactonohydrolase

Steroid 17Alpha-Monooxygenase

Efflux of 2-hydroxy-atorvastatin-acid into bile

Transport of 5-S-Glutathionyl-Dopamine

Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

Metabolism (Formation/Degradation) of ArgGlyGly

Transport of Lipoate via Sodium Symport

Metabolism (Formation/Degradation) of GlntyrLeu

Metabolism (Formation/Degradation) of ValTrpVal

N-Acetylneuraminate 9-phosphate phosphohydrolase

Fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)

N-acetylglucosamine-6-phosphate deacetylase

Leukotriene C4 carboxypeptidase

L-dopachrome isomerase 1

Efflux of N-desisopropyl-fluvastatin into bile for excretion into faeces

3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase

Phosphatidylinositol-3, 4, 5-Trisphosphate 3-Phosphatase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of PheGlnPhe

5'-nucleotidase (XMP)

Ribonucleoside triphosphate reductase UTP

Metabolism (Formation/Degradation) of ArgAlaAla

Ethanol monooxygenase

ABC bile acid transporter

Cholestanetriol 26-Monooxygenase

Efflux of sulphate-conjugate-3-methoxy-acetaminophen into hepatic vein

SPHMYLN181181_hs_ATPt

Transport of Sphingomyelin (D18:1/18:1), Active

Metabolism (Formation/Degradation) of PhetyrGln

Betaine-aldehyde dehydrogenase

2-Amino-4-Hydroxy-6- (Erythro-1, 2, 3-Trihydroxypropyl) Dihydropteridine Triphosphate Phosphohydrolase (Alkaline Optimum)

PCHOLOLE_HSABCt

Transport of 1-Oleoylglycerophosphocholine (Delta 9)

Metabolism (Formation/Degradation) of PhePhe

Palmitoyl Coenzyme A Hydrolase

PCHOLPALM_HSPLA2

Formation of 1-Palmitoylglycerophosphocholine by Phospholipase A2

Palmitoyl Coenzyme A Hydrolase

Hydrolysis of glycylycine for uptake

Metabolism (Formation/Degradation) of ArgSerSer

7-Dehydrochenodeoxycholic acid ABC bile acid transporter

Metabolism (Formation/Degradation) of TyrArgGlu

Transport of Bile Acid, Tauroursodeoxycholate, Active Transport

Metabolism (Formation/Degradation) of HisArgCys

Metabolism (Formation/Degradation) of ProLeuArg

2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase

Metabolism (Formation/Degradation) of ArgPheArg

Formation of Dopamine

Metabolism (Formation/Degradation) of IleProLys

Adrenaline Secretion via Secretory Vesicle (ATP Driven)

Fatty-acyl-CoA elongation (n-C18:3CoA)

Stearoyl Coenzyme A 9-Desaturase

Hydroxyacylglutathione hydrolase

Cytochrome P450 2A6

Efflux of 3-alpha-iso-pravastatin into bile

Arachidonate 5-lipoxygenase

Methylsterol Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Fatty acyl CoA synthase n C80CoA lumped reaction

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Folylpolyglutamate Synthetase (10Fthf)

Metabolism (Formation/Degradation) of TyrPhetyr

Squalene monooxygenase

PCHOLN281_HSPLA2

Formation of Lysopc A C28:1 (Delta 5) by Phospholipase A2

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of GlyLysCys

Hydroxylation of Androst-4-Ene-3, 17-Dione

Cytochrome P450 lanosterol 14 alpha demethylase NADP

2-methylcitrate synthase

Conversion of 2-hydroxy-atorvastatin-lactone to its acid form in hepatocytes

Efflux of 3-S-hydroxy-pravastatin-tetranor into bile

Leukotriene D4 dipeptidase

NADP phosphatase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Metabolism (Formation/Degradation) of LysCysHis

PCHOL2PALM_HSPLA2

Formation of 2-Palmitoylglycerophosphocholine by Phospholipase A2

Phosphatidate Phosphatase

Efflux of acetaminophen by P-gp from the enterocytes into lumen

Ribonucleoside-diphosphate reductase (UDP)

Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active Transport

5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase

Uptake of acetaminophen-mercapturate-conjugate by the hepatocytes

Efflux of N-desmethyl-rosuvastatin into bile

Metabolism (Formation/Degradation) of ValArgGly

Palmitoyl Coenzyme A Hydrolase

SPHMYLN18120_hs_ATPt

Transport of Sphingomyelin (D18:1/20:0), Active

SPHMYLN18116_hs_ATPt

Transport of Sphingomyelin (D18:1/16:0), Active Transport

Tetrahydrofolate Transport via Anion Antiport

Efflux of lovastatin acid by P-gp from the enterocytes into lumen

Metabolism (Formation/Degradation) of CysLeuThr

Hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

Cytidine deaminase

Estrone-Sulphate Transport by ABCa8

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of PheAsnMet

Phosphatidylinositol-3-phosphate 3-phosphatase

Hydrolysis of leucylglycine

Metabolism (Formation/Degradation) of TrpGlyLeu

Metabolism (Formation/Degradation) of AsntyrPhe

Ribonucleoside-diphosphate reductase (CDP)

Transport of 1-Docosahexenoylglyceroethanolamine (Delta 4, 7, 10, 13, 16, 19), Lpe (22:6)

Thiamin phosphatase

Phosphatidate Phosphatase

SPHMYLN181201_hs_ATPt

Transport of Sphingomyelin (D18:1/20:1), Active

Transport of 5Alpha-Androstane-3Alpha, 17Beta-Diol, Extracellular

UDP-glucose glucophosphohydrolase

Hypoxanthine dehydrogenase

Metabolism (Formation/Degradation) of CysAsnMet

Aminopeptidase (pro-gly)

3-Methoxytyramine:oxygen oxidoreductase (deaminating)

Glucuronidated bile acid excretion (HCA-24G)

Hydroxymethylbilane synthase

Hydrolysis of Acetyl-Lysine

IMP cyclohydrolase

21-Deoxycortisol, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Metabolism (Formation/Degradation) of ArgCysSer

Dehydrodolichol phosphate phosphatase (liver)

Pregnenolone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Palmitoyl Coenzyme A Hydrolase

2-Aminoacrylate hydrolysis

Glucuronidated bile acid excretion (HCA-6G)

Arachidonate 12-Lipoxygenase

Lactaldehyde dehydrogenase

Transport of 1-Eicosatrienoylglycerophosphocholine (Delta 11, 14, 17)

ATP-binding Cassette (ABC) TCDB:3.A.1.208.8

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Phosphatidylserine flippase

Transport of 5Beta-Cholestane-3Alpha, 7Alpha, 12Alpha, 24S, 25-Pentol, Active Transport

(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

Metabolism (Formation/Degradation) of AspGluTrp

N acetylputrescine oxygen oxireductase deaminating

Transport of 5(S)-HPETE, Active Transport

Efflux of atorvastatin lactone by P-gp from the enterocytes into lumen

3-Methylimidazole acetaldehyde:NAD+ oxidoreductase

PCHOLN203_HSPLA2

Formation of 1-Dihomo-Linolenoylglycerophosphocholine (20:3, Delta 8, 11, 14), Lysopc A C20:3 by Phospholipase A2

Transport of Estriol

Metabolism (Formation/Degradation) of GlnProGlu

Palmitoyl Coenzyme A Hydrolase

Transport of 3Beta-Hydroxyandrost-5-En-17-One

Metabolism (Formation/Degradation) of PhetyrLys

3-sulfinopyruvate hydrolase (spotaneous reaction)

Metabolism (Formation/Degradation) of Trptyrtyr

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Steroid 21-Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of TrpSertyr

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Metabolism (Formation/Degradation) of AspHisCys

Riboflavin transport out (ATP dependent)

Transport of 1-Arachidonoyl-Sn-Glycero-3-Phosphoethanolamine

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Metabolism (Formation/Degradation) of HisArgSer

Sterol 14Alpha-Demethylase

Isocholic acid ABC bile acid transporter

Nicotinamide ribonucleotide phosphohydrolase

Metabolism (Formation/Degradation) of ArgAlaThr

Fatty-acid-CoA thioesterase (tetradecanoate)

Spontaneous reaction

Beta-Glucuronidase

PCHOL2STE_HSPLA2

Formation of 2-Stearoylglycerophosphocholine by Phospholipase A2

N-Acetyl-L-aspartate amidohydrolase

Transport of Deoxycholate

Imidazole acetaldeyde dehydrogenase

Stearoyl Coenzyme A 9-Desaturase

Methylamine:oxygen oxidoreductase (deaminating) (copper-containing)

Transport of 16Alpha-Hydroxydehydroepiandrosterone, Endoplasmatic Reticulum

Leukotriene-B4 20-Monooxygenase

Formation of 1-Arachidonoylglycerophosphoinositol by Phospholipase A2

Formation of 2-Linoleoylglycerophosphoethanolamine by Phospholipase A2

Glycine hydroxymethyltransferase, reversible

5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

Metabolism (Formation/Degradation) of GlnHisLys

3Alpha, 7Alpha-Dihydroxy-5Beta-Cholestan-26-Al:NAD+ Oxidoreductase Bile Acid Biosynthesis

B-Alanine Secretion via Secretory Vesicle (ATP Driven)

Stearoyl Coenzyme A 9-Desaturase

ATP maintenance requirement

Metabolism (Formation/Degradation) of CysGluHis

Transport of 7Alpha, 12Alpha-Dihydroxycholest-4-En-3-One, Active Transport

PCHOLN28_HSPLA2

Formation of Lysopc A C28:0 by Phospholipase A2

Metabolism (Formation/Degradation) of AlaArgGly

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Metabolism (Formation/Degradation) of LeuVal

Melatonin:NADP oxidoreductase

2-aminomuconate reductase

Transport of 5, 8, 11, 14, 17-Eicosapentenoic Acid, Extracellular Space

SPHMYLN180241_hs_ATPt

Transport of Sphingomyelin (D18:0/24:1), Active Transport

Nucleoside-diphosphatase (dUDP)

Metabolism (Formation/Degradation) of IleGlnGlu

Transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine

5-Methyltetrahydrofolate Transport via Anion Exchange

PCHOLN205_HSPLA2

Formation of 1-Eicosapentenoylglycerophosphocholine (Delta 5, 8, 11, 14, 17), Sn1-Lpc (20:5) by Phospholipase A2

Fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

Pyridoxamine 5'-phosphate oxidase

Phosphatidylethanolamine flippase

Metabolism (Formation/Degradation) of AsntyrGly

Metabolism (Formation/Degradation) of AlaHisAla

Metabolism (Formation/Degradation) of HisTrpHis

Cholesterol 24-Hydroxylase

Metabolism (Formation/Degradation) of LeuAlaArg

Sialidase, Cytosol (Neu2)

7-Dehydrocholic acid ABC bile acid transporter

Efflux of AM4N9-cyclosporine into bile

Fatty acyl-CoA peroxisomal transport via ABC system (16:0)

Methenyltetrahydrofolate cyclohydrolase

Transport of 7Z, 10Z-Hexadecadienoic Acid into Extracellular Space

Transport of 1-Dihomo-Linolenoylglycerophosphoethanolamine (20:3, Delta 8, 11, 14)

4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase

Excretion of 7-beta-OH-gliclazide-glucuronide into bile

Transport of 15(R)-HEPE, Extracellular Space, Active Transport

Cytochrome P450 2C19

3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase

5'-nucleotidase (CMP)

Efflux of cerivastatin-M1 into bile

Metabolism (Formation/Degradation) of ArgArgLys

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of HisGluGln

PCHOLLINL_HSPLA2

Formation of 1-Linoleoylglycerophosphocholine (Delta 9, 12) by Phospholipase A2

Dehydrodolichol diphosphate phosphatase (liver)

BIOMASS_reaction

Generic Human Biomass Reaction

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Formation of 3-Hydroxy-3-Methyl-Glutarate

Palmitoyl Coenzyme A Hydrolase

Transport of Pregnenolone, Extracellular

Metabolism (Formation/Degradation) of HisCysCys

Methylsterol Monooxygenase

L-Tyrosine, Tetrahydrobiopterin:Oxygen Oxidoreductase (3-Hydroxylating)

H2O transport via diffusion

Alpha-Galactosidase

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

4A-Hydroxytetrahydrobiopterin Dehydratase

Metabolism (Formation/Degradation) of Tyrtyr

Metabolism (Formation/Degradation) of LysGlnPhe

Efflux of 3-keto-5,6,-dihydroxy-pravastatin into bile

Metabolism (Formation/Degradation) of TrpAspAsp

Efflux of acetaminophen-sulphate into hepatic vein

Metabolism (Formation/Degradation) of ArgLeuPhe

Bilirubin beta-diglucuronide transport MDR

Metabolism (Formation/Degradation) of ThrGlnGlu

Palmitoyl Coenzyme A Hydrolase

Conversion of lactone form of 6-beta-hydroxy-lovastatin to acid form

Transport of Lignocericyl Coenzyme A from Cytosol to Peroxisome.

Fatty acyl CoA synthase n C120CoA

Formation of Mevalonate-Lactone

Metabolism (Formation/Degradation) of GluLeu

Transport of 14, 15-EET, Active Transport

Metabolism (Formation/Degradation) of TyrThr

5-Hydroxy-L-Tryptophan Secretion via Secretory Vesicle (ATP Driven)

Metabolism (Formation/Degradation) of ArgAlaPhe

Aldehyde dehydrogenase (phenylacetaldehyde, NAD)

Oxidized glutathione irreversible active transport (rbc)

Transport of Cis, Cis-11, 14-Eicosadienoyl Coenzyme A, Active Transport

Deoxycholic acid 3-sulfate ABC bile acid transporter

SPHMYLN1824_hs_ATPt

Transport of Sphingomyelin (D18:0/24:0), Active Transport

Transport (ATP-Dependent) into Extracellular Space

Transport of 11-Cis-Eicosenoate

Peroxidase (multiple substrates)

Ribonucleoside triphosphate reductase ATP

Transport of Estrone, Extracellular

Efflux of 5-hydroxy-fluvastatin into bile for excretion into faeces

FAD diphosphatase

3-dehydro-deoxycholic acid formation

Transport of 1-Arachidonoyl-Glycero-3-Phosphocholine

Transport of Taurodeoxycholate

6-Phosphogluconolactonase

Transport by ABCa11 into Extracellular Space

Transport of Trans-Delta-2-Heptadecanoic Acid, Extracellular

Formation of 1-Eicosatrienoylglycerophosphoethanolamine (Delta 11, 14, 17), Lpe (20:3) by Phospholipase A2

Formation of 1-Docosahexenoylglyceroethanolamine (Delta 4, 7, 10, 13, 16, 19), Lpe (22:6) by Phospholipase A2

Lithocholic acid 3-sulfate ABC bile acid transporter

Palmitoyl Coenzyme A Hydrolase

PCHOLN183_HSPLA2

Formation of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 9, 12, 15) by Phospholipase A2

Efflux of AM1A-cyclosporine into bile

Sialidase, Cytosol (Neu2)

17Alpha-Hydroxypregnenolone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

L-Tyrosine, L-Dopa:Oxygen Oxidoreductase

Metabolism (Formation/Degradation) of TrpLys

Transport of 15(S)-HEPE, Active Transport

Transport of 6-Trans-Leukotriene B4, Active Transport

PCHOLPALME_HSABCt

Transport of 1-Palmitoleoylglycerophosphocholine (Delta 9)

Phosphatidylinositol-4,5-bisphosphate 5-phosphatase

L-Formylkynurenine hydrolase

Acetylcholinesterase

Transport of pristanoylcoa from cytosol to peroxisomes.

7Alpha-Hydroxycholest-4-En-3-One 12Alpha-Hydroxylase

Metabolism (Formation/Degradation) of ProPhe

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

5'-nucleotidase (dUMP)

Phosphatidylcholine flippase

Putrescine:oxygen oxidoreductase (deaminating)

Transport of 17Alpha-Hydroxypregnenolone Sulfate, Extracellular

Metabolism (Formation/Degradation) of TrpHisMet

Pyridoxal dehydrogenase

Efflux of glucuronide-conjugate of 3-methoxy-acetaminophen into hepatic vein

Cytochrome P450 2C9

SPHMYLN18115_hs_ATPt

Transport of Sphingomyelin (D18:1/15:0), Active Transport

PCHOLN204_HSABCt

Transport of 1-Eicosatetraenoylglycerophosphocholine (Delta 8, 11, 14, 17), Sn1-Lpc (20:4)

Secretion of Glycine via Secretory Vesicle (ATP Driven)

PCHOLSTE_HSABCt

Transport of 1-Stearoylglycerophosphocholine

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of GlnHisHis

PCHOLN201_HSPLA2

Formation of 1-Eicosenoylglycerophosphocholine (Delta 11) , Sn1-Lpc (20:1) by Phospholipase A2

5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)

Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

Metabolism (Formation/Degradation) of GlnLysLys

N, N-Dimethylglycine:Electron-Transfer Flavoprotein Oxidoreductase (Demethylating)

Hydrolysis of Fatty Acyl Coenzyme A (14:1)

Retinal dehydrogenase

UDPglucose 6-dehydrogenase

PCHLN225_HSABCt

Transport of 1-Docosahexenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16, 19), Sn1-Lpc (22:6)

Metabolism (Formation/Degradation) of SerArgAla

Transport of Leukotriene B5, Active Transport

Transport of Thromboxane B2

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Transport (ATP-Dependent) into Extracellular Space

Vitamin D3 25-hydroxylase

Metabolism (Formation/Degradation) of TrptyrGln

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Steroid 21-Monooxygenase

Palmitoyl CoA desaturase n C160CoA n C161CoA

Adenosylhomocysteinase

Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

3-dehydro-lithocholic acid ABC bile acid transporter

Metabolism (Formation/Degradation) of AspProLys

Phosphatidylinositol-3, 4, 5-Trisphosphate 3-Phosphatase

SPHMYLN_HsATPte

Extracellular Transport of Sphingomyeline, Active Transport

N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)

Porphobilinogen synthase

Metabolism (Formation/Degradation) of ProAsnCys

Efflux of thiomethyl-sulphoxide-acetaminophen-sulphate into hepatic vein

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of AspMetAsp

L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

Sphingomyelin deacylase

Sphingolipid C-4 Hydroxylase (Des2)

Riboflavin transport (ATP dependent)

Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active

Lithocholic acid 1beta-hydroxylase

PCHOL2OLE_HSABCt

Transport of 2-Oleoylglycerophosphocholine

Metabolism (Formation/Degradation) of CysAspPhe

Unspecific Monooxygenase

Phosphatidylserine flippase

Diphosphoglycerate phosphatase

Ursocholic acid ABC bile acid transporter

Aldehyde Dehydrogenase (NAD+)

Palmitoyl Coenzyme A Hydrolase

Linoleoyl-CoA, hydrogen-donor:oxygen oxidoreductase

Metabolism (Formation/Degradation) of TrpGlyAsp

Formation of Hexanoic Acid

Beta-Aminopropion aldehyde NAD+ oxidoreductase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.7

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Metabolism (Formation/Degradation) of LeuProArg

Glycogen phosphorylase (amyls -> glc-D)

Retinal dehydrogenase (NADPH)

Phosphatase (pan4p)

Nucleoside triphosphate pyrophosphorylase (gtp)

Linoleoyl Coenzyme A, Ferrocytochrome B5:Oxygen Oxidoreductase (6, 7 Cis-Dehydrogenating)

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

PCHOLPALME_HSPLA2

Formation of 1-Palmitoleoylglycerophosphocholine (Delta 9) by Phospholipase A2

H+/K+ gastric/non-gastric P-ATPase and ABC ATPase

Metabolism (Formation/Degradation) of PheLeuAsp

Choline phosphatase

2,3-diketo-5-methylthio-1-phosphopentane degradation reaction

Phosphatidate Phosphatase

PCHOLN261_HSPLA2

Formation of Lysopc A C26:1 (Delta 5) by Phospholipase A2

Stearoyl CoA desaturase n C180CoA n C181CoA

Transport of docosapentenoylcoa into peroxisomes.

Aldehyde dehydrogenase (indole-3-acetaldehyde, NAD)

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of TrpIleLys

Metabolism (Formation/Degradation) of ValPheArg

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of PheLysAla

Water And Glycerol Transport by Aqp

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

DIGALSGALSIDEATPte

Extracellular Transport of Digalactosylceramidesulfate, Active Transport

Metabolism (Formation/Degradation) of AlaLysThr

Metabolism (Formation/Degradation) of TyrValMet

Efflux of thiomethyl-sulphoxide-acetaminophen-glucuronide into hepatic vein

Sulfite oxidase

UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)

Nucleoside triphosphate pyrophosphorylase (ditp)

FAOXOHC22C22DCc

Fatty Acid Omega Oxidation (W-Ohc22->C22Dc)

10-formyltetrahydrofolate:NADP+ oxidoreductase

Fructose 2 6 bisphosphate 2 phosphatase

Metabolism (Formation/Degradation) of TrpProLeu

Transport of 21-Hydroxyallopregnanolone, Extracellular

GTP cyclohydrolase I

Secretion of Dopamine via Secretory Vesicle (ATP Driven)

Metabolism (Formation/Degradation) of ArgArgMet

Nucleoside triphosphate pyrophosphorylase (itp)

2-deoxy-D-ribose 1-phosphate phosphorylase

Lactonization of hydroxy metabolite of nifedipine in hepatocytes

Metabolism (Formation/Degradation) of AspAlaArg

Transport of 5, 6-EET, Active Transport

Transport of 2-Methoxyestradiol-17Beta, Extracellular

Metabolism (Formation/Degradation) of Leutyrtyr

IBUP_RCYPCARhep

Oxidation of R-3-hydroxy ibuprofen to R-carboxy ibuprofen

Beta-N-Acetylhexosaminidase

Conversion of 4-hydroxy-atorvastatin-lactone to its acid form in hepatocytes

Methylsterol Monooxygenase

Metabolism (Formation/Degradation) of HisAsp

Efflux of simvastatin by P-gp from the enterocytes into lumen

NAD diphosphatase

Transport (ATP-Dependent) into Extracellular Space

Metabolism (Formation/Degradation) of HisLysAla

Glutathione hydralase (periplasmic)

Metabolism (Formation/Degradation) of TrpLeuVal

H2O endoplasmic reticulum transport

Efflux of alpha-Tocopherol into the lyphatics in chylomicrons

Excretion of 6-alpha-OH-gliclazide into bile

PCHOLN2254_HSPLA2

Formation of 1-Docosapentenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16), Sn1-Lpc (22:5)-W6 by Phospholipase A2

N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)

Steryl-Sulfatase

Efflux of 12-hydroxy tacrolimus into intestinal lumen by ABC transporter

Deoxyadenosine deaminase

Thiamine diphosphate transport in via anion antiport, mitochondria

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of ProGlnPro

5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)

PCHOLHEP_HSABCt

Transport of 1-Heptadecanoylglycerophosphocholine

Metabolism (Formation/Degradation) of ArgCysGly

Metabolism (Formation/Degradation) of GluMet

Leukotriene-B4 20-Monooxygenase

Transport of 2-Hydroxyestrone, Extracellular

Ursodeoxycholic acid 3-sulfate ABC bile acid transporter

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

Transport of stearidonylcoa into peroxisomes.

Carbamoyl-phosphate synthase (glutamine-hydrolysing)

Efflux of 6-hydroxy-fluvastatin into bile for excretion into faeces

Efflux of 6-beta-hydroxy simvastatin acid into bile

Pyrophasphatase (dephospho-CoA)

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

5'-nucleotidase (dTMP)

H2O transport, lysosomal

Metabolism (Formation/Degradation) of MetGlntyr

Transport (ATP-Dependent) into Extracellular Space

Transport of 2-Methoxyestrone, Extracellular

Transport of 1-Alkyl 2-Acteylglycerol 3-Phosphocholine

Metabolism (Formation/Degradation) of SerPheLys

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

BIOMASS_maintenance

Biomass maintenance reaction without replication precursors

Metabolism (Formation/Degradation) of TrpPhe

Hydrolysis of glycylsarcosine for uptake

Metabolism (Formation/Degradation) of ProGluLys

Metabolism (Formation/Degradation) of ProTrpLys

Transport of 17Alpha-Hydroxypregnenolone, Extracellular

Steroyl Coenzyme A, Hydrogen-Donor:Oxygen Oxidoreductase Polyunsaturated Fatty Acid Biosynthesis

2HATVACIDGLUCteb

Efflux of 2-hydroxy-atorvastatin-acyl-glucuronide into bile

Palmitoyl Coenzyme A Hydrolase

Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)

Folylpolyglutamate Synthetase (Dhf)

Fatty-acid-CoA thioesterase (hexanoate)

AHANDROSTANGLCte

Glucuronidated compound transport

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Xanthine dehydrogenase

PCHOLN15_HSABCt

Transport of 1-Pentadecanoylglycerophosphocholine, Sn1-Lpc (15:0)

Folate Transport by ABCa11

Cytochrome P450 2C9

Efflux of 5,6-epoxy-3-alpha-iso-pravastatin into bile

Release of 3-hydroxy-lovastatin acid form into bile

Urea, water cotransport

R group coenzyme a ligase

Formation of 1-Arachidonoyl-Glycero-3-Phosphocholine by Phospholipase A2

Metabolism (Formation/Degradation) of ThrAsntyr

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

3MOX4HOXPGALDOX

3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase

Thiamin pyrophosphatase

D-myo-Inositol 1,3,4-trisphosphate 1-phosphohydrolase

Metabolism (Formation/Degradation) of HisGlnAla

Fructose-bisphosphatase

Estrone-Sulphate Transport by ABCa11

Phylloquinone transport

Metabolism (Formation/Degradation) of LeuAsnAsp

Metabolism (Formation/Degradation) of TrpThrtyr

Metabolism (Formation/Degradation) of IleAsnHis

Phospholipase D

Stearoyl Coenzyme A 9-Desaturase

Formation of Thromboxane B2

Dopamine 4-O-Glucuronide Transport

Efflux of 6-beta-hydroxy-methyl-simvastatin-acid into bile

Efflux of AM1c-cyclosporine into bile

Fatty acyl CoA synthase n C100CoA

Transport of 5Alpha-Androstane-3, 17-Dione, Extracellular

Leukotriene A-4 hydrolase

PCHOLOLE_HSPLA2

Formation of 1-Oleoylglycerophosphocholine (Delta 9) by Phospholipase A2

Efflux of AM1-cyclosporine into bile

Glucuronidated bile acid excretion (HDCA-6G)

Metabolism (Formation/Degradation) of ProHistyr

PCHOLDET_HSPLA2

Formation of 1-Eicosatrienoylglycerophosphocholine (Delta 11, 14, 17) by Phospholipase A2

5'-nucleotidase (AMP)

Steryl-sulfatase

Aldehyde dehydrogenase (phenylacetaldehyde, NADP)

Transport of 1-Palmitoylglycerophosphocholine

Propionyl Coenzyme A C2-Trimethyltridecanoyltransferase

Conversion of 6-beta-hydroxy simvastatin lactone to acid form

Bilirubin monoglucuronide transport MDR

Steryl-Sulfatase

Thiamine-triphosphatase

Aldose reductase

Metabolism (Formation/Degradation) of LysArgLeu

Methylsterol Monooxygenase

5'-nucleotidase

GDP-D-mannose dehydratase

Efflux of AM4N-cyclosporine into bile

Transport of 12 Hydroxy Arachidonic Acid, Extracellular Space, Active Transport

Phosphatidic acid phosphatase

Nucleoside diphosphatase ADP

Spermidine:(acceptor) oxidoreductase

Sphingomyelin Phosphodiesterase

Phosphoserine phosphatase (L-serine)

L-aminoadipate-semialdehyde dehydrogenase (NADH)

3',5'-cyclic-nucleotide phosphodiesterase

Transport of 21-Hydroxypregnenolone, Active Transport

D-myo-Inositol-3,4-bisphosphate 4-phosphohydrolase

Efflux of 31-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

Sphingomyelinase

PCHOLDEIC_HSPLA2

Formation of 1-Eicosadienoylglycerophosphocholine (Delta 11, 14) by Phospholipase A2

Stearoyl Coenzyme A 9-Desaturase

Efflux of pravastatin glucuronide into bile

Transport of L-Threonate by Active Transport

Metabolism (Formation/Degradation) of HisMet

34DHXMANDACOX_NADP

3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

Beta-Galactosidase

Metabolism (Formation/Degradation) of AsntyrThr

Fatty Acid Omega-Hydroxylase

Palmitoyl Coenzyme A Hydrolase

Taurodeoxycholic acid 3-sulfate ABC bile acid transporter

Steroid, Reduced-Adrenal-Ferredoxin:Oxygen Oxidoreductase (11-Hydroxylating)

Fatty acyl CoA synthase n C180CoA

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

4HOXPACDOX_NADP

4HOXPACDOX LPAREN NADP RPAREN

Efflux of 15, 31-O-Didesmethyl-tacrolimus into bile

Excretion of 6-beta-OH-gliclazide-glucuronide into bile

Glucosylceramidase

PCHOLN204_HSPLA2

Formation of 1-Eicosatetraenoylglycerophosphocholine (Delta 8, 11, 14, 17), Sn1-Lpc (20:4) by Phospholipase A2

Metabolism (Formation/Degradation) of TrpGlnGln

Pravastatin efflux into lumen for excretion into feces

Cholic acid 3-sulfate ABC bile acid transporter

FAOXOHC16C16DCc

Fatty Acid Omega Oxidation (W-Ohc16->C16Dc)

Efflux of pitavastatin by BCRP from the enterocytes into lumen

Transport of 11-Cis-Eicosenoate, Active

Cytochrome P450 2C8

Dolichyl-Diphosphate Phosphohydrolase

Phospholipase D

Cytochrome P450 2C9

Formation of 7-Hydroxy-Octanoate

ADPribose diphosphatase

Fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)

PCHOLMYR_HSPLA2

Formation of 1-Myristoylglycerophosphocholine by Phospholipase A2

Formation of 1-Heptadecanoylglycerophosphoethanolamine (C17:0 Pe) by Phospholipase A2

Methylsterol Monooxygenase

Palmitoyl Coenzyme A Hydrolase

3',5'-cyclic-nucleotide phosphodiesterase

Transport of W-Hydroxyl Arachidonic Acid, Active Transport

SPHMYLN18122_hs_ATPt

Transport of Sphingomyelin (D18:1/22:0), Active Transport

Efflux of 13,15-O-didesmethyl tacrolimus into intestinal lumen by ABC transporter

Phosphatidylethanolamine flippase

Metabolism (Formation/Degradation) of MetPheArg

Fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)

Phospholipase D

17-beta-D-glucuronide transport (ATP-dependent)

Transport (ATP-Dependent) into Extracellular Space

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

3-Methoxytyramine secretion via secretory vesicle (ATP driven)

Alpha glucosidase

5ADTSTSTERONEGLCte

Glucuronidated compound transport

Glucuronidated bile acid excretion (HDCA-24G)

Metabolism (Formation/Degradation) of LysTrpArg

Fatty-acid-CoA thioesterase (dodecanoate)

Metabolism (Formation/Degradation) of IleAsp

Acetone monooxygenase

6-phosphogluconolactonase

Metabolism (Formation/Degradation) of TrpGluLeu

H2O transport, Golgi apparatus

Metabolism (Formation/Degradation) of ValSerArg

Steryl-Sulfatase

Release of iboprofen acyl glucuronides into the portal blood

Sialidase, Cytosol (Neu2)

Formyl coa hydrolase

Steryl-sulfatase

Transport of 1-Stearoylglycerophosphoethanolamine

Formation of 1-Hexadecenoylglycerophosphoethanolamine (C16:1 Pe, Delta 9) by Phospholipase A2

Unspecific Monooxygenase

Beta-ureidopropionase (D-3-amino-isobutanoate forming)

Metabolism (Formation/Degradation) of HisProLys

5'-nucleotidase (IMP)

SPHMYLN18118_hs_ATPt

Transport of Sphingomyelin (D18:1/18:0), Active

Nicotinate-mononucleotide adenylyltransferase

Acetylcholine Secretion via Secretory Vesicle (ATP Driven)

Hydrolysis of Alanylalanine

Metabolism (Formation/Degradation) of ValLeuPhe

Nitric Oxide Synthase (NO forming)

Formation of Methyl-Succinate

Cystathionine beta synthase

Efflux of AM1AL-cyclosporine into bile

Formation of 1-Linoleoylglycerophosphoethanolamine (Delta 9, 12) by Phospholipase A2

Hydrolysis of Glycylleucine in the small intestine for cellular uptake

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

3-dehydrocholic acid formation

N4 AcetylaminobutanalNAD oxidoreductase

Metabolism (Formation/Degradation) of LeuAspLys

Stearoyl Coenzyme A 9-Desaturase

Stearoyl Coenzyme A 9-Desaturase

Nalpha-(beta-alanyl)-L-histidine hydrolase IR

Phenethylamine oxidase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Fatty-acid-CoA thioesterase (hexadecanoate)

Metabolism (Formation/Degradation) of ProArgAsp

Metabolism (Formation/Degradation) of IleTrptyr

Fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)

Metabolism (Formation/Degradation) of GlyValHis

Active Transport of Tetradecenoate (N-C14:1)

Release of 3-hydroxy-iso-delta-4,5-hydroxy acid form of lovastatin into bile

Adenine deaminase

Metabolism (Formation/Degradation) of ProArgCys

Metabolism (Formation/Degradation) of AspLysGlu

SPHMYLN181221_hs_ATPt

Transport of Sphingomyelin (D18:1/22:1), Active

R group coenzyme a ligase

Formation of 21-Hydroxypregnenolone

17Beta-Estradiol 3-Glucosiduronic Acid Transport by ABCa8

Metabolism (Formation/Degradation) of ArgHisThr

Efflux of AM9-cyclosporine into bile

Glucuronidated bile acid excretion (CDCA-24G)

D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase

Uptake of acetaminophen by the hepatocytes

Transport of Trans, Cis, Cis-2, 11, 14-Eicosatrienoic Acid

Metabolism (Formation/Degradation) of ArgArg

Thiamine Triphosphate Transport in via Anion Antiport

Efflux of 4-hydroxy-atorvastatin-acid into bile

Metabolism (Formation/Degradation) of GluMetHis

Metabolism (Formation/Degradation) of PhePheAsn

Adenosine monophosphate deaminase

ADPmannose diphosphatase

Palmitoyl Coenzyme A Hydrolase

Efflux of losartan by P-gp from the enterocytes into lumen

Formation of 1-Tridecanoylglycerophosphoethanolamine (C13:0 Pe) by Phospholipase A2

Metabolism (Formation/Degradation) of MetAsntyr

Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD

Aminomuconate-semialdehyde dehydrogenase

Formation of Ethylmalonic Acid

Sialidase, Cytosol (Neu2)

Metabolism (Formation/Degradation) of TyrAspArg

Metabolism (Formation/Degradation) of LeuLeuTrp

Cytochrome P450 2E1

ABC transporter

Transport of Lathosterol, Energy Dependant

NADP nucleosidase

Transport of 1-Oleoylglycerophosphoethanolamine (Delta 9)

Phosphatidylinositol phospholipase C

Metabolism (Formation/Degradation) of ArgGluPro

Guanosine aminohydrolase EC:3.5.4.15

Fatty acid synthase n C180

Metabolism (Formation/Degradation) of ProValGln

Formation of 1-Oleoylglycerophosphoethanolamine (Delta 9) by Phospholipase A2

Alanyl aminopeptidase (cys-gly)

Cholate Coenzyme A Ligase

5 diphosphoinositol 1 2 3 4 6 pentakisphosphate diphosphohydrolase

Sterol 14Alpha-Demethylase

Efflux of acetaminophen-glutathione-conjugate from enterocytes into portal blood

PCHOLSTE_HSPLA2

Formation of 1-Stearoylglycerophosphocholine by Phospholipase A2

Transport of Cis-5, 8-Tetradecadienoic Acid, Active Transport

11Beta-Hydroxyprogesterone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Inositol-1,3,4-trisphosphate 4-phosphatase

D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase

Metabolism (Formation/Degradation) of ThrIleArg

Formation of 7-Ketolithocholate

Metabolism (Formation/Degradation) of Phetyr

Metabolism (Formation/Degradation) of LysValTrp

PCHOLEIC_HSABCt

Transport of 1-Eicosadienoylglycerophosphocholine (Delta 11, 14)

Metabolism (Formation/Degradation) of AsnMetPro

Leukotriene-B4 20-Monooxygenase

Thiamine monophosphate transport, mitochondrial

Cytosine deaminase

Transport of 16Alpha-Hydroxydehydroepiandrosterone, Extracellular

4-Pyridoxal secretion

PCHOLN1836_HSPLA2

Formation of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 6, 9, 12) by Phospholipase A2

Fatty-acyl-CoA elongation (n-C20:4CoA)

Pyridoxamine:oxygen oxidoreductase (deaminating)

Efflux of 3,5-dihydrodiol-simvastatin-lactone form into bile

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Transport of L-Ascorbate by SVCT1 or SVCT2 transporter

ABC bile acid transporter

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Metanephrine secretion via secretory vesicle (ATP driven)

Phospholipase D

Hydroxylation of 3- (3-Hydroxyphenyl)Propionate

Metabolism (Formation/Degradation) of TyrCysThr

L-Normetanephrine seceretion via secretory vesicle (ATP driven)

Sn-Glycero-3-Phosphocholine Cholinephosphohydrolase

Hydrolysis of Leucylleucine in the small intestine for cellular uptake

Aldehyde dehydrogenase (acetaldehyde, NADP)

Formation of 1-Didecanoylglycerophosphoethanolamine (C12:0 Pe) by Phospholipase A2

D-myo-Inositol-1,4-bisphosphate 1-phosphohydrolase

Efflux of desacyl dehydro-pravastatin into bile

Stearoyl Coenzyme A 9-Desaturase

Fumarylacetoacetase

Glycocholic acid 3-sulfate ABC bile acid transporter

3-dehydro-lithocholic acid formation

Transport (ATP-Dependent) into Extracellular Space

Metabolism (Formation/Degradation) of LysPheIle

Conversion of 6-beta-carboxy simvastatin lactone to acid form

Transport of Androst-4-Ene-3, 17-Dione, Extracellular

Metabolism (Formation/Degradation) of MetArgLeu

Transport of 14, 15-DIHETE, Active Transport

Metabolism (Formation/Degradation) of TyrAlaPhe

Coprostanol ABC bile acid transporter

Maltodextrin glucosidase (maltotriose)

Taurocholic acid 3-sulfate ABC bile acid transporter

Leukotriene-A4 Hydrolase

Apocarboxylase formation

Metabolism (Formation/Degradation) of AspHisPro

Metabolism (Formation/Degradation) of CysCys

Efflux of sulphate-thiomethyl-acetaminophen conjugate into hepatic vein

Fatty acid omega-hydroxylase

Active Transport of 8-Dehydrocholesterol

Release of 6-exomethylene-lovastatin-acid form into bile

Deoxycytidine deaminase

Ethanolamine phosphate phosphatase

Metabolism (Formation/Degradation) of ThrArgtyr

Steroid, Hydrogen-Donor:Oxygen Oxidoreductase (17-Alpha-Hydroxylating)

Metabolism (Formation/Degradation) of ArgProMet

Metabolism (Formation/Degradation) of GluTrpAla

Metabolism (Formation/Degradation) of SerCysArg

Metabolism (Formation/Degradation) of GlytyrLys

Hydrolase Class RXN R02973

Arachidonate 5-Lipoxygenase

Metabolism (Formation/Degradation) of GluThr

Deamino-NAD+ nucleotidohydrolase

Palmitoyl Coenzyme A Hydrolase

Oxidation of allopurinol to oxypurinol in hepatocytes

Aldehyde Dehydrogenase (NAD+)

Unspecific Monooxygenase

Efflux of 3-S-hydroxy-pravastatin into bile

Efflux of glucuronide-thiomethyl-acetaminophen conjugate into hepatic vein

Steroid 17Alpha-Monooxygenase

Prostaglandin-Endoperoxide Synthase

Excretion of dehydro-gliclazide into bile

PCHOLN2254_HSABCt

Transport of 1-Docosapentenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16), Sn1-Lpc (22:5)-W6

Transport of Cholesta-5, 7-Dien-3Beta-Ol, Active Transport

Phosphatidylglycerol phosphate phosphatase (homo sapiens)

Folate Transport via Anion Antiport

Metabolism (Formation/Degradation) of AlaGlyLys

Efflux of acetaminophen-mercapturate-conjugate from enterocytes into portal blood

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Metabolism (Formation/Degradation) of LystyrIle

Formation of 1-Dihomo-Linolenoylglycerophosphoethanolamine (20:3, Delta 8, 11, 14) by Phospholipase A2

Choline phosphate phosphatase

Unspecific Monooxygenase

Tyrosinase: 5, 6-Dihydroxyindole Oxygen Oxidoreductase

Transport of 11-Deoxycorticosterone, Extracellular

Palmitoyl Coenzyme A Hydrolase

Dopamine 3-O-Glucuronide Transport

Metabolism (Formation/Degradation) of ArgtyrVal

Hydrolysis of ibuprofen-CoA in hepatocytes

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Glutathione Peroxidase

Formation of 5-Hydroxy-Hexanoate

Formation of 1-Arachidonoyl-Sn-Glycero-3-Phosphoethanolamine by Phospholipase A2

Metabolism (Formation/Degradation) of TyrArgSer

1-Phosphatidyl-1D-Myo-Inositol-3, 4-Bisphosphate 4-Phosphohydrolase

PCHOLDOC_HSABCt

Transport of 1-Docosahexaenoylglycerophosphocholine

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Metabolism (Formation/Degradation) of TyrGlu

Metabolism (Formation/Degradation) of ProCys

Taurochenodeoxycholic acid 3-sulfate ABC bile acid transporter

PCHOLHEP_HSPLA2

Formation of 1-Heptadecanoylglycerophosphocholine by Phospholipase A2

Hydrolysis of Prolylglycine in the small intestine for cellular uptake

Efflux of 6-beta-carboxy-simvastatin-acid form into bile

Quinolinate Synthase Eukaryotic

R group coenzyme a ligase

Cholesterol efflux (ATP depedent)

Transport of 11-Deoxycortisol, Extracellular

Transport of 7-Ketolithocholate, Active Transport

Palmitoyl Coenzyme A Hydrolase

Inorganic diphosphatase

Bile Acid Transport by ABCa8

CTP synthase (glutamine)

Iodide:hydrogen-peroxide oxidoreductase 3

Metabolism (Formation/Degradation) of AsnAsnArg

Inositol-1,4-bisphosphate 4-phosphatase

Metabolism (Formation/Degradation) of ValTrpPhe

Metabolism (Formation/Degradation) of TyrCysGly

Transport of Stearoyl-CoA from cytosol to peroxisomes

Metabolism (Formation/Degradation) of MetMetIle

Inositol-1,3-bisphosphate 3-phosphatase

Formation of 1-Pentadecanoylglycerophosphoethanolamine (C15:0 Pe) by Phospholipase A2

7Alpha-Hydroxycholest-4-En-3-One 12Alpha-Hydroxylase

De-lactonization of cerivastatin-M31 to cerivastatin-M23 in hepatocytes

Phosphatidylinositol 4,5-bisphosphate phospholipase C

Transport of W-Carboxy Leukotriene B4, Active Transport

Active transport

IMP dehydrogenase

Efflux of AM1c9-cyclosporine into bile

Transport of 1-Hexadecenoylglycerophosphoethanolamine (C16:1 Pe, Delta 9)

Metabolism (Formation/Degradation) of GluIleLys

B-ketoacyl synthetase (palmitate, n-C16:0)

Quinine 3-Monooxygenase

DHCHOLESTANATEATP

Transport of 3Alpha, 7Alpha-Dihydroxy-5Beta-Cholestanate, Active Transport

Acetol monooxygenase

Stearoyl Coenzyme A 9-Desaturase

Leukotriene-B4 20-Monooxygenase

SPHMYLN18117_hs_ATPt

Transport of Sphingomyelin (D18:1/17:0), Active

Conversion of 3-hydroxy-lovastatin lactone to acid form

L-glutamate secretion via secretory vesicle (ATP driven)

Beta-N-Acetylhexosaminidase

4-Hydroxybenzoyl Coenzyme A Hydrolase

Methylsterol Monooxygenase

Efflux of cerivastatin by P-gp or BCRP from the enterocytes into lumen

Metabolism (Formation/Degradation) of GluArgLeu

5'-nucleotidase (dAMP)

Methylsterol Monooxygenase

Metabolism (Formation/Degradation) of ProTrpThr

Alpha,alpha-trehalase

Metabolism (Formation/Degradation) of ThrPheArg

Metabolism (Formation/Degradation) of TrpArgAla

Efflux of cyclosporine by P-gp from the enterocytes into lumen

Unspecific Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Lactaldehyde dehydrogenase

Efflux of acetaminophen-glucuronide-conjugate from enterocytes into portal blood

Imidazolonepropionase

3-dehydro-deoxycholic acid ABC bile acid transporter

Transport of 2-Hydroxyestradiol-17Beta, Extracellular

Phospholipase A2

FAOXOHMC10DC10c

Fatty acid omega oxidation(w-OHMC10-->DC10)c

Heme Transport by ABCg2

SPHMYLN181161_hs_ATPt

Transport of Sphingomyelin (D18:1/16:1), Active Transport

Metabolism (Formation/Degradation) of LysGluGlu

Glycodeoxycholate Amidohydrolase

Export Mediated by ATP Binding Cassette (ABC) Transporters

Aldehyde Dehydrogenase (NAD+)

PCHOLN24_HSPLA2

Formation of 1-Lignocericylglycerophosphocholine (24:0), Lysopc A C24 by Phospholipase A2

Metabolism (Formation/Degradation) of PheLysPro

Palmitoyl Coenzyme A Hydrolase

Efflux of cerivastatin-M23 into bile

Lathosterol, NADPH:oxygen 5-oxidoreductase

Sterol 14Alpha-Demethylase

D-Glyceraldehyde dehydrogenase

PCHOLN224_HSABCt

Transport of 1-Docosatetraenoylglycerophosphocholine (Delta 7, 10, 13, 16), Sn1-Lpc (22:4)

Metabolism (Formation/Degradation) of ProProPro

Histamine Secretion via Secretory Vesicle (ATP Driven)

Retinyl ester hydrolase (11-cis)

Transport of 1-Tridecanoylglycerophosphoethanolamine (C13:0 Pe)

Metabolism (Formation/Degradation) of TrpThrGlu

Metabolism (Formation/Degradation) of TyrAla

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of LeuSerTrp

Biotin Transport via Sodium Symport

Transport of 1-Heptadecanoylglycerophosphoethanolamine (C17:0 Pe)

Biliary excretion of ibuprofen from hepatocytes

Transport of 7Alpha-Hydroxycholest-4-En-3-One, Active Transport

Tetrahydrobiopterin-4a-carbinolamine dehydratase

Metabolism (Formation/Degradation) of ThrSerArg

Transport of 5Alpha-Androstane-3, 17-Dione, Endoplasmatic Reticulum

Transport of 1-Linoleoylglycerophosphoethanolamine (Delta 9, 12)

Spermine oxidase

Fatty-acid-CoA thioesterase (octadecanoate)

Thiamine exit from the neterocytes

N1-Methylnicotinamide transport

Metabolism (Formation/Degradation) of SerTrpHis

B-ureidopropionase

Metabolism (Formation/Degradation) of IleGlyArg

Palmitoyl Coenzyme A Hydrolase

Transport of Lithocholate, Active Transport

Transport of 9 (10)-Epome, Active Transport

(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

Hydrolysis of Trans, Cis, Cis-2, 11, 14-Eicosatrienoyl Coenzyme A to Trans, Cis, Cis-2, 11, 14-Eicosatrienoic Acid

Excretion of carboxy-gliclazide into bile

25/26-Hydroxycholesterol 7Alpha-Hydroxylase

Glucuronidated compound transport

Methylsterol Monooxygenase

Transport (ATP-Dependent) into Extracellular Space

Aminobutyraldehyde dehydrogenase

Ribonucleoside-diphosphate reductase (GDP)

Transport of 5Alpha-Pregnane-3, 20-Dione, Extracellular

Ribonucleoside triphosphate reductase CTP

Microsomal Epoxide Hydrolase

Glycogen debranching enzyme

Conversion of 3-hydroxy simvastatin lactone to acid form

Sterol 14Alpha-Demethylase

Glucuronidated compound transport

Metabolism (Formation/Degradation) of MetGlyArg

Unspecific Monooxygenase

PCHOL2STE_HSABCt

Transport of 2-Stearoylglycerophosphocholine

Efflux of simvastatin dihydroxy acid form into bile

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

NAD nucleosidase

Aldehyde dehydrogenase (acetaldehyde, NAD)

Fatty acyl CoA synthase n C140CoA

Efflux of AM1A4N-cyclosporine into bile

Palmitoyl Coenzyme A Hydrolase

41R1H2MAE12BOOX

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Desaturation of Myristic Acid to 9-Tetradecenoic Acid

Metabolism (Formation/Degradation) of GlyLysPhe

Kynurenine-Oxoglutarate Transaminase

Metabolism (Formation/Degradation) of TrpAlaPro

Metabolism (Formation/Degradation) of ArgProThr

Transport (ATP-Dependent) into Extracellular Space

34DHPLACOX_NADP

34DHPLACOX LPAREN NADP RPAREN

Methylsterol Monooxygenase

Sterol 14Alpha-Demethylase

Transport of 13-Docosenoylcoa into Peroxisomes

FACOAE1839Z12Z15Z

Alpha-Linolenoyl-CoA hydrolase (18:3(9Z,12Z,15Z))

Transport of 12S-HHT, FATP

Asparagine synthase (glutamine-hydrolysing)

PCHOLN201_HSABCt

Transport of 1-Eicosenoylglycerophosphocholine (Delta 11) , Sn1-Lpc (20:1)

Efflux of cyclosporine-sulphate into bile

Metabolism (Formation/Degradation) of ThrMetArg

Metabolism (Formation/Degradation) of ProLysPro

Metabolism (Formation/Degradation) of PheAsp

Transport (ATP-Dependent) into Extracellular Space

Efflux of rosuvastatin-5S-lactone into bile

Metabolism (Formation/Degradation) of HisGlu

Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Microsomal Epoxide Hydrolase

Cytochrome P450 3A5

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Efflux of AM19-cyclosporine into bile

Palmitoyl Coenzyme A Hydrolase

Excretion of Methyl-hydroxy-gliclazide into bile

L-Arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Metabolism (Formation/Degradation) of IleSerArg

Metabolism (Formation/Degradation) of AspLysHis

Metabolism (Formation/Degradation) of ArgLysAsp

Thioesterase/ hydrolase for release of des-isoproylpropionic-acid-fluvastatin in hepatocytes

Steryl-Sulfatase

Stearoyl Coenzyme A Desaturase (N-C18:0CoA -> N-C18:1CoA)

Metabolism (Formation/Degradation) of CysGluTrp

Excretion of 7-beta-OH-gliclazide into bile

Acetylornithine deacetylase

Phosphatidate Phosphatase

4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

Metabolism (Formation/Degradation) of GlnLysTrp

L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

PCHOLN225_HSABCt

Transport of 1-Docosapentenoylglycerophosphocholine (Delta 7, 10, 13, 16, 19), Sn1-Lpc (22:5)-W3

PCHOLN225_HSPLA2

Formation of 1-Docosapentenoylglycerophosphocholine (Delta 7, 10, 13, 16, 19), Sn1-Lpc (22:5)-W3 by Phospholipase A2

L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22

Lysophospholipase

Efflux of triol metabolite of pravastatin into bile

Metabolism (Formation/Degradation) of LeuTrp

Metabolism (Formation/Degradation) of TrpGluPro

Transport (ATP-Dependent) into Extracellular Space

Acireductone Synthase (Homo Sapiens)

Metabolism (Formation/Degradation) of ProProArg

PCHOLN1836_HSABCt

Transport of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 6, 9, 12)

Glucuronidated bile acid excretion (LCA-24G)

Betaine-aldehyde dehydrogenase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Transport of 15-Tetracosenoate, Diffusion

Glycoursodeoxycholic acid 3-sulfate ABC bile acid transporter

Metabolism (Formation/Degradation) of TrpMetVal

D-Glucuronolactone:NAD+ oxidoreductase

Beta-N-Acetylhexosaminidase

Phosphatidylserine Transport by ABCa1

Metabolism (Formation/Degradation) of ArgValCys

3-Dehydrochenodeoxycholic acid ABC bile acid transporter

4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)

Phosphoribosylformylglycinamidine synthase

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Glutamine phosphoribosyldiphosphate amidotransferase

SPHMYLN18114_hs_ATPt

Transport of Sphingomyelin (D18:1/14:0), Active Transport

Steryl-Sulfatase

Metabolism (Formation/Degradation) of ValLystyr

5'-nucleotidase (dGMP)

Microsomal Epoxide Hydrolase

Transport of 2-Linoleoylglycerophosphoethanolamine

Metabolism (Formation/Degradation) of ValVal

Efflux of 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus into bile

Transport of 5, 12, 20-Trihete, Active Transport

Acylphosphatase

Inorganic triphosphatase

Glucuronidated bile acid excretion (CA-24G)

Efflux of tacrolimus into intestinal lumen by P-gp

L-Methionine oxidase

Arginine deiminase

Conversion of lactone to acid form of atorvastatin in hepatocytes

Metabolism (Formation/Degradation) of ThrThrArg

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Transport of Bile Acid, Ursodeoxycholate, Active Transport

Coproporphyrinogen oxidase (O2 required)

Metabolism (Formation/Degradation) of PhePheThr

Cholesterol efflux (ATP depedent), golgi

Methylsterol Monooxygenase

Metabolism (Formation/Degradation) of AspGlu

Efflux of AM1c-glucuronide into bile

L-Serine hydro-lyase

Sphinganine 1-phosphate phosphatase

PCHOLN183_HSABCt

Transport of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 9, 12, 15)

Pantothenate sodium symporter II

Prostaglandine E1 transport (ATP-dependent)

GABA Secretion via Secretory Vesicle (ATP Driven)

Iodide:hydrogen-peroxide oxidoreductase 4

Fatty-acyl-CoA elongation (n-C20:5CoA)

Metabolism (Formation/Degradation) of AspAsnGlu

TSTSTERONEGLCte

Glucuronidated compound transport

Chenodeoxycholic acid 6alpha-hydroxylase

Nicotinamide-nucleotide amidase

Efflux of 6-epipravastatin into bile

Transport of 5(S)-HETE, Active Transport

Palmitoyl Coenzyme A Hydrolase

Efflux of fluvastatin into bile for excretion into faeces

Formation of 1-Myristoylglycerophosphoethanolamine (C14:0 Pe) by Phospholipase A2

Efflux of 7-hydroxy-3-alpha-iso-pravastatin into bile

Nitric Oxide Synthase (No Forming)

Glycodeoxycholic acid 3-sulfate ABC bile acid transporter

Metabolism (Formation/Degradation) of CystyrAsn

Phosphatidylinositol-4-phosphate 4-phosphatase

Cystathionine g lyase

Dihydropyrimidinase (5,6-dihydrouracil)

Transport of 3Alpha-Hydroxy-5Beta-Androstan-17-One, Endoplasmatic Reticulum

BIOMASS_maintenance_noTrTr

Biomass maintenance reaction without replication, transcription, and translation precursors

Efflux of 4-hydroxy-atorvastatin-lactone into bile

Transport of 1-Myristoylglycerophosphoethanolamine (C14:0 Pe)

Hypothetical enyme

Metabolism (Formation/Degradation) of HisHisLys

Metabolism (Formation/Degradation) of GlnTrpGlu

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Efflux of 3-hydroxy-simvastatin-acid form into bile

Metabolism (Formation/Degradation) of ProHis

Unspecific Monooxygenase

Methylsterol Monooxygenase

Transport of behenoylcoa into peroxisomes

Metabolism (Formation/Degradation) of MetHisLys

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of GlnAsnGln

PCHOLN19_HSPLA2

Formation of 1-NoNADecanoylglycerophosphocholine, Sn1-Lpc (19:0) by Phospholipase A2

L-glutamate 5-semialdehyde dehydratase (spontaneous)

Efflux of 13,31-O-Didesmethyl-tacrolimus into bile

Stearoyl Coenzyme A 9-Desaturase

Metabolism (Formation/Degradation) of IleArgIle

2-Phenylacetamide Amidohydrolase

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Transport of 1-Didecanoylglycerophosphoethanolamine (C12:0 Pe)

Glycerophosphocholine Phosphodiesterase

Taurohyocholic acid ABC bile acid transporter

Chloride Transport via Hydroxide Antiport (2:1)

Fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)

Metabolism (Formation/Degradation) of GlyHisAsn

Urate:Oxygen Oxidoreductase

L-Tyrosine oxidase

CAMP transport (ATP-dependent)

Unspecific Monooxygenase

Transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine

Monoamine oxidase (L-Normetanephrine)

Transport of phytanoylcoa from cytosol to peroxisomes.

Threonine synthase

Palmitoyl Coenzyme A Hydrolase

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

Exo-Alpha-Sialidase

Biotin transport via sodium symport

24-Hydroxycholesterol 7Alpha-Hydroxylase

PAILPALM_HSPLA2

Formation of 1-Palmitoylglycerophosphoinositol by Phospholipase A2

Biotinidase (biotin)

Carboxylesterase

Glucuronidated bile acid excretion (DCA-24g)

Heme oxygenase 1

Prostaglandine E2 transport (ATP-dependent)

Cytochrome P450 2D6

Progesterone, Reduced Ferredoxin:Oxygen Oxidoreductase (11-Hydroxylating)

Vitamin Transport by ABCa4

Isochenodeoxycholic acid ABC bile acid transporter

Glutathione transport into mitochondria

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

NADH:cob(III)alamine oxidoreductase

Metabolism (Formation/Degradation) of CysGlnMet

Hyocholic acid ABC bile acid transporter

Transport of 12-Hydroperoxyeicosa-5, 8, 10, 14-Tetraenoate, by FATP

UDPglucuronate uridine-monophosphohydrolase

Protoporphyrinogen oxidase (aerobic)

Transport of 18 Hydroxy Arachidonic Acid, Extracellular Space, Active Transport

Beta-Glucuronidase

Secretion of Noradrenaline via Secretory Vesicle (ATP Driven)

IBUP_SCYPCARhep

Oxidation of S-3-hydroxy ibuprofen to S-carboxy ibuprofen

Spontaneous reaction

Alpha-N-Acetylgalactosaminidase

Conversion of lactone to open acid form of rosuvastatin

Transport of Allopregnanolone, Extracellular

2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

Exo-Alpha-Sialidase

Palmitoyl Coenzyme A Hydrolase

Transport of 4-S-Glutathionyl-5, 6-Dihydroxyindoline

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Myo-inositol 1-phosphatase

Metabolism (Formation/Degradation) of ArgGluGlu

Pantothenate Sodium Symporter Ii

Triacylglycerol Lipase

Metabolism (Formation/Degradation) of TrpGluGly

Fatty-acid-CoA thioesterase (hexadecenoate)

Transport of 17Alpha-Hydroxyprogesterone, Extracellular

Transport of Bile Acid, Glycoursodeoxycholate, Active Transport

Palmitoyl Coenzyme A Hydrolase

Steryl-Sulfatase

Kynurenine-Oxoglutarate Transaminase

Transport of Bile Acid, Sulfochenodeoxycholate, Active Transport

Retinyl ester hydrolase (9-cis)

D-myo-Inositol 1,3,4,5-tetrakisphosphate 3-phosphohydrolase

3MOX4HOXPGALDOX_NADP

3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase

SPHMYLN18123_hs_ATPt

Transport of Sphingomyelin (D18:1/23:0), Active

Phosphatidylinositol 4-phosphate phospholipase C

Tauroursodeoxycholic acid 3-sulfate ABC bile acid transporter

Leukotriene Transport by ABCa8

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Uroporphyrinogen-III synthase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of LysValPhe

Transport of Docosahexaenoate

Efflux of AM1c4N9-cyclosporine into bile

12-Dehydrocholic acid ABC bile acid transporter

De-lactonization of cerivastatin-M22 to cerivastatin-M1 in hepatocytes

Formation of 1-Docosatetraenoyglycerophosphoethanolamine (22:4, Delta 7, 10, 13, 16) by Phospholipase A2

Alpha-Aminobutyryl Histidine Hydrolase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of LysLysLys

Metabolism (Formation/Degradation) of TrpThrIle

Metabolism (Formation/Degradation) of TyrLeuArg

Metabolism (Formation/Degradation) of AspValAsn

5-Formyltetrahydrofolate Transport via Anion Exchange

Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -> N-C18:2CoA)

Glucuronate 1-phosphate phosphatase

Steryl-sulfatase

1-Eicosatrienoylglycerophosphoethanolamine (Delta 11, 14, 17), Lpe (20:3)

Metabolism (Formation/Degradation) of TrpIleTrp

Transport of 1-Palmitoylglycerophosphoethanolamine

Transport of Hexadecanediocacid by FATP

Metabolism (Formation/Degradation) of GluAsnLeu

Efflux of atorvastatin acid by P-gp from the enterocytes into lumen

N-Acyl-Aliphatic-L-Amino Acid Amidohydrolase

PCHOLN224_HSPLA2

Formation of 1-Docosatetraenoylglycerophosphocholine (Delta 7, 10, 13, 16), Sn1-Lpc (22:4) by Phospholipase A2

Transport of 8, 9-EET, Active Transport

1D-myo-Inositol 4-phosphate phosphohydrolase

Retinal dehydrogenase (NADPH)

Glucosamine-6-phosphate deaminase

Efflux of midazolam by P-gp from the enterocytes into lumen

Phosphatidylinositol-3, 4, 5-Trisphosphate 3-Phosphatase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

L-Phenylalanine:Oxygen Oxidoreductase (Decarboxylating)

Methylsterol Monooxygenase

PCHOL2OLE_HSPLA2

Formation of 2-Oleoylglycerophosphocholine by Phospholipase A2

Aldehyde dehydrogenase (pristanal, NAD)

Conversion of pro-durg lovastatin to active hydroxyacid form in hepatocytes

CGMP transport (ATP-dependent)

PCHOLDOC_HSPLA2

Formation of 1-Docosahexaenoylglycerophosphocholine by Phospholipase A2

Efflux of pitavastatin-M3 into bile

Metabolism (Formation/Degradation) of ArgValTrp

Transport of nervonylcoa into peroxisomes

Efflux of 2-hydroxy-atorvastatin-lactone into bile

Metabolism (Formation/Degradation) of HisLysGlu

1D-myo-Inositol 3-phosphate phosphohydrolase

Very-Long-Chain (3R)-3-Hydroxyacyl Coenzyme A Dehydratase

N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9

Excretion of 4-beta-OH-gliclazide into bile

Acid phosphatase (FMN)

Taurochenodeoxycholic acid 6alpha-hydroxylase

Na+/K+ Exchanging ATPase

5'-nucleotidase (UMP)

Metabolism (Formation/Degradation) of HisGlyLys

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Transport of 13(S)-HPODE, Active

Hydroxymethylglutaryl CoA synthase

Ribonucleoside-diphosphate reductase (ADP)

Metabolism (Formation/Degradation) of TyrTrpPhe

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

PCHOLMYR_HsABCt

Transport of 1-Myristoylglycerophosphocholine

Gamma-glutamyltransferase

Cytochrome P450 3A4

ATP-binding Cassette (ABC) TCDB:3.A.1.208.2

H2O transport mitochondrial

Metabolism (Formation/Degradation) of PheLeuHis

Glucuronidated bile acid excretion (LCA-3G)

Transport of W-Hydroxyl Leukotriene B4, Active Transport

Kynurenine 3 monooxygenase

Fatty acyl CoA synthase n C160CoA

Metabolism (Formation/Degradation) of GlyHisLys

PCHOLN205_HSABCt

Transport of 1-Eicosapentenoylglycerophosphocholine (Delta 5, 8, 11, 14, 17), Sn1-Lpc (20:5)

Palmitoyl Coenzyme A Hydrolase

5'-nucleotidase (dIMP)

Metabolism (Formation/Degradation) of TrpGlyVal

Steroyl Coenzyme A, Hydrogen-Donor:Oxygen Oxidoreductase Polyunsaturated Fatty Acid Biosynthesis

UDP-glucuronate glucuronohydrolase

Sialidase, Cytosol (Neu2)

Aldehyde dehydrogenase 4 hydroxyphenylacetaldehyde NAD

5Beta-Cholestane-3Alpha, 7Alpha, 12Alpha-Triol, NADPH:Oxygen Oxidoreductase (26-Hydroxylating) Bile Acid Biosynthesis

3-dehydro-chenodehydroxycholic acid formation

Tyrosinase: Dopamine Oxidation

Transport of 12 (13)-Epome, FATP

Quinine 3-Monooxygenase

Metabolism (Formation/Degradation) of TrpProGly

Efflux of 3-OH-acetaminophen into hepatic vein

5-Phosphonooxy-L-Lysine Phospho-Lyase

Palmitoyl Coenzyme A Hydrolase

Transport of 5-S-Glutathionyl-L-Dopa

Hydrolysis of glycylphenylalanine

Transport of 5Beta-Cholestane-3Alpha, 7Alpha, 26-Triol, Active Transport

N Formyl L kynurenine amidohydrolase

Metabolism (Formation/Degradation) of LeuPro

SPHMYLN1825_hs_ATPt

Transport of Sphingomyelin (D18:0/25:0), Active Transport

Sphingosine 1-phosphate phosphatase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of ThrtyrMet

Tyrosine:dopa oxidase (dopaquinone producing 2)

2HATVLACGLUCteb

Efflux of 2-hydroxy-atorvastatin-lactone-glucuronide into bile

Acetyl-CoA hydrolase

PCHOLN203_HSABCt

Transport of 1-Dihomo-Linolenoylglycerophosphocholine (20:3, Delta 8, 11, 14), Lysopc A C20:3

Efflux of rosuvastatin by BCRP from the enterocytes into lumen

FACOAE1836Z9Z12Z

Gamma-Linolenoyl-CoA hydrolase (18:3(6Z,9Z,12Z))

Conversion of simvastatin pro-drug to active form

4A-Hydroxytetrahydrobiopterin Dehydratase

Glutathione peridoxase

Efflux of lovastatin lactone by P-gp from the enterocytes into lumen

Formation of 9 (10)-Epome

Metabolism (Formation/Degradation) of GluGlu

DUTP diphosphatase

Metabolism (Formation/Degradation) of TrpMetArg

Transport of 15(S)-HPETE, Active Transport

PCHOL2LINL_HSPLA2

Formation of 2-Linoleoylglycerophosphocholine by Phospholipase A2

Microsomal Epoxide Hydrolase

Cytochrome P450 2C9

Metabolism (Formation/Degradation) of ValProTrp

5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase

L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

17Alpha-Hydroxypregnenolone Acetaldehyde-Lyase

Formation of Tyraminium

Transport of 7, 10, 13-Hexadecatrienoic Acid into Extracellular Space

Metabolism (Formation/Degradation) of LeuTrpArg

Efflux of 13-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

Prostaglandin G/H synthase

PCHOLN15_HSPLA2

Formation of 1-Pentadecanoylglycerophosphocholine, Sn1-Lpc (15:0) by Phospholipase A2

Metabolism (Formation/Degradation) of HisLysIle

N-Methylhistamine:oxygen oxidoreductase (deaminating)

Glycochenodeoxycholic acid 3-sulfate ABC bile acid transporter

Glycolaldehyde dehydrogenase

Metabolism (Formation/Degradation) of ThrGlntyr

Linoleoyl-CoA hydrolase (18:2(9Z,12Z))

Cholesterol 25-Hydroxylase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Transport by ABCg2 into Extracellular Space

Dopamine Beta-Monooxygenase

Excretion of 7-alpha-OH-gliclazide into bile

SPHMYLN18121_hs_ATPt

Transport of Sphingomyelin (D18:1/21:0), Active

Thiamine Monophosphate Transport in via Anion Antiport

Metabolism (Formation/Degradation) of SerArgTrp

Gamma-Glutamyl Hydrolase

Metabolism (Formation/Degradation) of PheThrLys

Transport of 11, 12-EET, FATP

Metabolism (Formation/Degradation) of HisLysVal

Myo-Inositol:oxygen oxidoreductase

Methionine adenosyltransferase

Metabolism (Formation/Degradation) of HisPheArg

Metabolism (Formation/Degradation) of SerLysHis

HCO3 equilibration reaction

Guanine deaminase

N-acetylglucosaminylphosphatidylinositol deacetylase

PCHOLN264_HSABCt

Transport of 1-Lignocericylglycerophosphocholine (24:0), Lysopc A C24

Metabolism (Formation/Degradation) of AsnPheCys

Pyridoxal 5-phosphate phosphatase

Pyridoxine 5-phosphate phosphatase

Proteolysis of apoC-Lys-btn

Dhea Transport by ABCa11

Fatty-acid-CoA thioesterase (octadecenoate)

Amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:3.2.1.33

Formation of 1-Palmitoylglycerophosphoethanolamine by Phospholipase A2

1-Alkyl 2-Acylglycerol 3-Phosphocholine Transport

Folylpolyglutamate Synthetase

L-Tyrosine:Oxygen Oxidoreductase

Palmitoyl Coenzyme A Hydrolase

Metabolism (Formation/Degradation) of MetTrpPhe

Unspecific Monooxygenase

Efflux of 15-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

S-Formylglutathione hydralase

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Universal metabolite ?

h2o

External database links

InChI Key: XLYOFNOQVPJJNP-UHFFFAOYSA-N
Reactome Compound: 109276, 113518, 113519, 113521, 141343, 1605715, 189422, 2022884, 29356, 351603, 5278291, 5668574, 5693747, 8851517
SEED Compound: cpd00001, cpd15275, cpd27222
CHEBI: CHEBI:10743, CHEBI:13352, CHEBI:13365, CHEBI:13419, CHEBI:15377, CHEBI:16234, CHEBI:27313, CHEBI:29356, CHEBI:29412, CHEBI:30490, CHEBI:33813, CHEBI:42043, CHEBI:42857, CHEBI:43228, CHEBI:44292, CHEBI:44641, CHEBI:44701, CHEBI:44819, CHEBI:5585, CHEBI:5594
Human Metabolome Database: HMDB01039, HMDB02111
KEGG Compound: C00001, C01328
MetaNetX (MNX) Chemical: MNXM2
KEGG Drug: D00001, D06322
BioCyc: META:CPD-15815, META:HYDROXYL-GROUP, META:OH, META:OXONIUM, META:WATER

Provided by MetaNetX (CC BY 4.0)

Old identifiers

h2o[c]

h2o in other models