Reaction: 15DMThr

Descriptive name:

Demethylation of tacrolimus to 15-O-desmethyl tacrolimus in hepatocytes

Model:

Recon3D

Reaction:

h_r + ahcys_r + tacr_r → amet_r + 15dmt_r

Metabolites:

Stoichiometry
BiGG ID
Name
-1.0
h_r
H+
-1.0
ahcys_r
S-Adenosyl-L-homocysteine
1.0
amet_r
S-Adenosyl-L-methionine
-1.0
tacr_r
Tacrolimus
1.0
15dmt_r
15-DMT or M-III, 15-O-desmethyl tacrolimus

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

Genes:

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Universal reaction ?

External database links

Old identifiers

    15DMThr

15DMThr in other models