BiGG Models

Metabolite: h_c

Descriptive name:

H+

Model:

Formula:

H

Charge:

0

Compartment:

Reactions:

BiGG ID

Name

Transport of Dodecanedioic Acid by FATP

Leukotriene-B4 20-Monooxygenase

ABC bile acid transporter

Bicarbonate transport (HCl/NaHCO3 exchange)

Transport of TrpProGly, Extracellular

Conversion of lactone form of 6-exomethylene-lovastatin to acid form

Glyoxylate oxidase

Taurocholic acid sulfotransferase

Transport of 1-Pentadecanoylglycerophosphoethanolamine (C15:0 Pe)

Formation of Sulfochenodeoxycholate

Fucose-1-phosphate guanylyltransferase

Adenosine deaminase

Carnitine O-Palmitoyltransferase

Transport of ThrArgtyr, Extracellular

Adenosine kinase

Acylcoa Hydrolase, Cis, Cis-11, 14-Eicosadienoyl Coenzyme A

Transport of ThrtyrMet, Extracellular

Excretion of 6-beta-OH-gliclazide into bile

Glucuronidated bile acid excretion (CDCA-3G)

Uridine transport in via proton symport

Retinal dehydrogenase

Dt-Diaphorase: NAD Quinone Oxireductase

Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

Carbonyl Reductase (NADPH)

Testicular 17-beta-hydroxysteroid dehydrogenase

Thiamine diphosphokinase

Nucleoside-diphosphatase (dCDP)

Cholate Coenzyme A Ligase

S-Adenosyl-L-Methionine:Phosphatidyl-N-Methylethanolamine N-Methyltransferase

Uptake of acetaminophen-glutathione-conjugate by the hepatocytes

Phosphatidylcholine transporter

Steryl-Sulfatase

Adenosine kinase

Retinoic acid hydroxylation (P450)

PCHOLN19_HSABCt

Transport of 1-NoNADecanoylglycerophosphocholine, Sn1-Lpc (19:0)

Prostaglandin-Endoperoxide Synthase

3-Oxo-5Alpha-Steroid 4-Dehydrogenase (NADP+)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

UTP-glucose-1-phosphate uridylyltransferase (irreversible)

Transport of LeuLeuTrp, Extracellular

Pyridoxamine kinase

Hydrolysis of Tetradecadienoyl Coenzyme A to Cis-5, 8-Tetradecadienoic Acid

Inositol-1,4,5-trisphosphate 3-kinase

Hydroxyprogesterone Transport, Active

Transport of HisGluGln, Extracellular

Uptake of acetaminophen-glucuronide-conjugate by the hepatocytes

PCHOLN226_HSPLA2

Formation of 1-Docosahexenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16, 19), Sn1-Lpc (22:6) by Phospholipase A2

PCHOL2LINL_HSABCt

Transport of 2-Linoleoylglycerophosphocholine

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

N-acetylgalactosamine kinase

3Beta-Hydroxysteroid-4Alpha-Carboxylate 3-Dehydrogenase (Decarboxylating)

L-sulfolactate dehydrogenase (NAD+)

Ornithine mitochondrial transport via proton antiport

Efflux of cerivastatin-M24 into bile

NAD Dependent 11-Hydroxythromboxane B2 Dehydrogenase

Cerivastatin uptake by hepatocytes by active transport

Hexadecanal:NADP+ delta2-oxidoreductase EC:1.3.1.27

Dihydropyrimidinase (dihydrothymine)

Neolactotetraosylceramide Alpha-2, 3-Sialyltransferase

Transport of LeuAspLys, Extracellular

Transport of ArgGlyGly, Extracellular

Glutamine transport (Na, H coupled)

Signal Peptidase I

Cytidine transport in via proton symport

Steryl-sulfatase

Transport of Pregnenolone Sulfate, Extracellular

Retinyl ester hydrolase

Transport of TrpProLeu, Extracellular

Ammonia transport via proton antiport

Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.

Fatty acid omega-hydroxylase

L-gulonate 3-dehydrogenase

Sterol 14Alpha-Demethylase

4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase

3-Dehydrocholic acid ABC bile acid transporter

Ribosylnicotinamide kinase

Asparagine transport (Na, H coupled)

Efflux of cysteine-conjugate-acetaminophen into hepatic vein

Steryl-Sulfatase

Hydroxymethylglutaryl CoA reductase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Phosphatidylinositol 4-phosphate 5-kinase

Histidine transport (Na, H coupled)

Phosphatidylglycerol Transport by ABCa3

Cytochrome P450 2F1

Aldehyde Reductase

Steroid 21-Monooxygenase

Sepiapterin reductase

4-trimethylaminobutyraldehyde dehydrogenase

Transport of ArgProMet, Extracellular

Transport of Homocarnosine

Thyroid peroxidase

Transport of PheAsp, Extracellular

Uridine kinase ATPUridine

Ceramide Glucosyltransferase

Long-Chain-Fatty-Acid---Coa Ligase

Fatty-acyl-CoA elongation (n-C20:4CoA)

Transport of ValTrpVal, Extracellular

Transport of 3Alpha, 7Alpha, 12Alpha-Trihydroxy-5Beta-Cholestanoate, Active Transport

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

Conversion of 6-beta-hydroxy-methyl simvastatin lactone to acid form

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Transport of 3Alpha-Hydroxy-5Beta-Androstan-17-One, Extracellular

D-Lactaldehyde:NADP+ 1-oxidoreductase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

PCHOLLINL_HSABCt

Transport of 1-Linoleoylglycerophosphocholine (Delta 9, 12)

Transport of HisLysThr, Extracellular

Transport of AspAlaArg, Extracellular

Phosphatidylinositol 4-phosphate 3-kinase

Thiamine transport in via proton antiport

1-alpha hydroxylation of 25-hydroxy vitamin D

Transport of TyrPhetyr, Extracellular

Transport of TyrGlu, Extracellular

Transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Transport of 15-Tetracosenoate, Active Transport

Platelet-activating factor acetylhydrolase

Excretion of gliclazide into bile

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of LysValTrp, Extracellular

Glucuronidated bile acid excretion (DCA-3G)

L-Dehydroascorbate lactonohydrolase

Steroid 17Alpha-Monooxygenase

Fucosylgalactoside 3-Alpha-Galactosyltransferase

Catechol O-Methyltransferase

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Transport of Ornithine, Peroxisomal

Efflux of 2-hydroxy-atorvastatin-acid into bile

Formation of sulfocysteine

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of CysAspPhe, Extracellular

Transport of 5-S-Glutathionyl-Dopamine

Transport of Lipoate via Sodium Symport

Phosphoadenylyl-sulfate reductase (thioredoxin)

Formation of 3-methoxy-acetaminophen in hepatocytes

Fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)

Efflux of N-desisopropyl-fluvastatin into bile for excretion into faeces

Phenylalanine mitochondrial transport via proton symport

3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase

Palmitoyl Coenzyme A Hydrolase

Catechol O-Methyltransferase

Lipoamide Transport

Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

3Beta-Hydroxy-Delta5-Steroid Dehydrogenase

Aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

Transport of IleSerArg, Extracellular

Ethanol monooxygenase

Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

ABC bile acid transporter

Cholestanetriol 26-Monooxygenase

Pyridoxine kinase

Efflux of sulphate-conjugate-3-methoxy-acetaminophen into hepatic vein

Transport of LysGluGlu, Extracellular

SPHMYLN181181_hs_ATPt

Transport of Sphingomyelin (D18:1/18:1), Active

UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56

Betaine-aldehyde dehydrogenase

Phosphatidylinositol 3-phosphate 4-kinase

D-Galactose:NADP+ 1-oxidoreductase

2-Amino-4-Hydroxy-6- (Erythro-1, 2, 3-Trihydroxypropyl) Dihydropteridine Triphosphate Phosphohydrolase (Alkaline Optimum)

PCHOLOLE_HSABCt

Transport of 1-Oleoylglycerophosphocholine (Delta 9)

Globotriaosylceramide 3-Beta-N-Acetylgalactosaminyltransferase

Transport of TrpGlyAsp, Extracellular

Transport of HisPheArg, Extracellular

Palmitoyl Coenzyme A Hydrolase

PCHOLPALM_HSPLA2

Formation of 1-Palmitoylglycerophosphocholine by Phospholipase A2

Palmitoyl Coenzyme A Hydrolase

7-Dehydrochenodeoxycholic acid ABC bile acid transporter

Transport of TyrAla, Extracellular

Aldose reductase (acetol)

Transport of Bile Acid, Tauroursodeoxycholate, Active Transport

Transport of ProGluLys, Extracellular

Transport of LeuVal, Extracellular

Formation of Dopamine

Adrenaline Secretion via Secretory Vesicle (ATP Driven)

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of GlyLysCys, Extracellular

Hydroxypyruvate decarboxylase

Fatty-acyl-CoA elongation (n-C18:3CoA)

Stearoyl Coenzyme A 9-Desaturase

Hydroxyacylglutathione hydrolase

Transport via Proton Antiport (Ammonium Transporter Rh Type C Or Type B) into Extracellular Space

Cytochrome P450 2A6

Efflux of 3-alpha-iso-pravastatin into bile

Methylsterol Monooxygenase

Transport of AlaAsnLeu, Extracellular

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Palmitoyl Coenzyme A Hydrolase

Transport of TyrArgSer, Extracellular

Fatty acyl CoA synthase n C80CoA lumped reaction

Alcohol dehydrogenase (ethanol, NADP)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Noradrenaline N-methyltransferase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Folylpolyglutamate Synthetase (10Fthf)

Dehydro-L-gulonate decarboxylase

Squalene monooxygenase

PCHOLN281_HSPLA2

Formation of Lysopc A C28:1 (Delta 5) by Phospholipase A2

L serine reversible transport via proton symport

Transport of HisArgCys, Extracellular

Palmitoyl Coenzyme A Hydrolase

Hydroxylation of Androst-4-Ene-3, 17-Dione

Cytochrome P450 lanosterol 14 alpha demethylase NADP

Folylpolyglutamate synthetase (10fthf)

Glutamate Decarboxylase

2-methylcitrate synthase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Conversion of 2-hydroxy-atorvastatin-lactone to its acid form in hepatocytes

Vacuolar amino acid transporter (gln-L), mitochondrial

Efflux of 3-S-hydroxy-pravastatin-tetranor into bile

Transport of ValArgGly, Extracellular

Formation of Homocitrulline

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

PCHOL2PALM_HSPLA2

Formation of 2-Palmitoylglycerophosphocholine by Phospholipase A2

Efflux of acetaminophen by P-gp from the enterocytes into lumen

Transport of ArgGluPro, Extracellular

Formation of 2-Hydroxy-Isovalerate

Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active Transport

Glycolysis / Glyconeogenesis EC:2.7.1.1

Uptake of acetaminophen-mercapturate-conjugate by the hepatocytes

N-acetylglucosamine kinase

Efflux of N-desmethyl-rosuvastatin into bile

L-Dopachrome Decarboxylation

N-acetylgalactosamine kinase (ITP)

Palmitoyl Coenzyme A Hydrolase

Very-Long-Chain Enoyl Coenzyme A Reductase

Glycerate kinase

UDP-Glucuronosyltransferase (UGT) cytosolic (hyodeoxycholic acid)

Acetylation of cysteine-conjugate-acetaminophen in hepatocytes

Transport of 3-(4-Hydroxyphenyl)Lactate, Mitochondrial

Transport of LysPheIle, Extracellular

SPHMYLN18120_hs_ATPt

Transport of Sphingomyelin (D18:1/20:0), Active

SPHMYLN18116_hs_ATPt

Transport of Sphingomyelin (D18:1/16:0), Active Transport

Dihydrolipoyl Dehydrogenase

Efflux of lovastatin acid by P-gp from the enterocytes into lumen

Potassium transport via proton antiport

Formation of 2-Methyl-3-Hydroxy-Valerate

Hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

Cytidine deaminase

Acetyl-CoA carboxylase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Estrone-Sulphate Transport by ABCa8

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Mannose-1-phosphate guanylyltransferase (GDP)

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

Palmitoyl Coenzyme A Hydrolase

Dihydrouracil dehydrogenase (NADP)

Glucose 6-phosphate dehydrogenase

Arginine mitochondrial transport via ornithine carrier

Hexokinase (D-glucose:ATP)

Transport of AspMetAsp, Extracellular

L-Tryptophan decarboxy-lyase

Transport of 1-Docosahexenoylglyceroethanolamine (Delta 4, 7, 10, 13, 16, 19), Lpe (22:6)

Deoxyadenosine kinase

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Nicotinate-nucleotide diphosphorylase (carboxylating)

Uptake of pravastatin by enterocytes via proton coupled mechanism

SPHMYLN181201_hs_ATPt

Transport of Sphingomyelin (D18:1/20:1), Active

Transport of 5Alpha-Androstane-3Alpha, 17Beta-Diol, Extracellular

5 10 methylenetetrahydrofolatereductase NADPH

Pyruvate kinase(3)

CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

UDP-glucose glucophosphohydrolase

Hypoxanthine dehydrogenase

D-alanine transport via proton symport

Glucuronidated bile acid excretion (HCA-24G)

Phosphoribosylglycinamide synthase

Choline phosphate cytididyltransferase

21-Deoxycortisol, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Pregnenolone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Palmitoyl Coenzyme A Hydrolase

UDP-N-acetylgalactosamine diphosphorylase

Dopaquinone isomerase 1

Glucuronidated bile acid excretion (HCA-6G)

Retinol dehydrogenase (all-trans)

3Beta-Hydroxysteroid 3-Dehydrogenase

Lactaldehyde dehydrogenase

Transport of 1-Eicosatrienoylglycerophosphocholine (Delta 11, 14, 17)

Transport of ArgArgLys, Extracellular

Cholest-5-Ene-3Beta, 7Alpha-Diol 3Beta-Dehydrogenase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.8

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Insosine kinase

Phosphatidylserine flippase

4'-Phosphopantothenate:L-cysteine ligase

Transport of 5Beta-Cholestane-3Alpha, 7Alpha, 12Alpha, 24S, 25-Pentol, Active Transport

(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

Transport of TyrTrpPhe, Extracellular

Transport of 5(S)-HPETE, Active Transport

Efflux of atorvastatin lactone by P-gp from the enterocytes into lumen

3-Methylimidazole acetaldehyde:NAD+ oxidoreductase

PCHOLN203_HSPLA2

Formation of 1-Dihomo-Linolenoylglycerophosphocholine (20:3, Delta 8, 11, 14), Lysopc A C20:3 by Phospholipase A2

TCDB:2.A.1.13.5 TCDB:2.A.1.13.1

Transport of Estriol

Palmitoyl Coenzyme A Hydrolase

Transport of 3Beta-Hydroxyandrost-5-En-17-One

Glutathione oxidoreductase

L-Cysteine:NAD+ Oxidoreductase;

(5Z, 13E)- (15S)-9Alpha, 11Alpha, 15-Trihydroxyprosta-5, 13-Dienoate:NADP+ 11-Oxidoreductase

3-sulfinopyruvate hydrolase (spotaneous reaction)

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Steroid 21-Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Nicotinate-nucleotide adenylyltransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Riboflavin transport out (ATP dependent)

Transport of 1-Arachidonoyl-Sn-Glycero-3-Phosphoethanolamine

Beta Alanine transport in via proton symport

Glucuronidation of 3- (3-Hydroxyphenyl)Propionate Hydroxy Derivative

Isocholic acid ABC bile acid transporter

Cysteinesulfinic acid oxidase

Fatty-acid-CoA thioesterase (tetradecanoate)

Beta-Glucuronidase

PCHOL2STE_HSPLA2

Formation of 2-Stearoylglycerophosphocholine by Phospholipase A2

Thromboxane-A Synthase

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Transport of GluGlu, Extracellular

DGTP:pyruvate 2-O-phosphotransferase, cytosol

Transport of Deoxycholate

Transport of PheLeu, Extracellular

Imidazole acetaldeyde dehydrogenase

Cardiolipin synthase (homo sapiens)

Stearoyl Coenzyme A 9-Desaturase

Transport of 16Alpha-Hydroxydehydroepiandrosterone, Endoplasmatic Reticulum

Pyrroline-5-carboxylate reductase

Demethylation of AM1c9 to AM1c4N9 in hepatocytes (alternative mechanism)

Dihydrofolate reductase (NAD+)

Leukotriene-B4 20-Monooxygenase

Transport of PhePheThr, Extracellular

Formation of 1-Arachidonoylglycerophosphoinositol by Phospholipase A2

Formation of 2-Linoleoylglycerophosphoethanolamine by Phospholipase A2

Dehydroascorbate oxidoreductase

5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

3Alpha, 7Alpha-Dihydroxy-5Beta-Cholestan-26-Al:NAD+ Oxidoreductase Bile Acid Biosynthesis

B-Alanine Secretion via Secretory Vesicle (ATP Driven)

Stearoyl Coenzyme A 9-Desaturase

Conjugation of oxypurinol to oxypurinol-1-riboside

ATP maintenance requirement

Transport of 7Alpha, 12Alpha-Dihydroxycholest-4-En-3-One, Active Transport

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Steroid sulfotransferase

PCHOLN28_HSPLA2

Formation of Lysopc A C28:0 by Phospholipase A2

Gamma-glutamylcysteine synthetase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Major Facilitator(MFS) TCDB:2.A.1.13.1

Melatonin:NADP oxidoreductase

NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9

2-aminomuconate reductase

2-Hydroxyphenylacetate Proton Symport, Cytosol

Transport of 5, 8, 11, 14, 17-Eicosapentenoic Acid, Extracellular Space

N-acetylneuraminate transport into lysososme

Diacylglycerol Cholinephosphotransferase

Transport of TyrAspArg, Extracellular

SPHMYLN180241_hs_ATPt

Transport of Sphingomyelin (D18:0/24:1), Active Transport

Transport of LysTrpArg, Extracellular

Nucleoside-diphosphatase (dUDP)

Lithocholic acid sulfotransferase

Histidine decarboxylase

Transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

PCHOLN205_HSPLA2

Formation of 1-Eicosapentenoylglycerophosphocholine (Delta 5, 8, 11, 14, 17), Sn1-Lpc (20:5) by Phospholipase A2

Fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

Phosphoribosylaminoimidazolesuccinocarboxamide synthase

D-galactose transport via proton symport

Hyaluronan synthase

Transport of TrpPhe, Extracellular

Pyridoxal kinase

N-acetyl-D-mannosamine kinase

Phosphatidylethanolamine flippase

2 HydroxybutyrateNAD oxidoreductase

Cholesterol 24-Hydroxylase

7-Dehydrocholic acid ABC bile acid transporter

Efflux of AM4N9-cyclosporine into bile

Fatty acyl-CoA peroxisomal transport via ABC system (16:0)

Methenyltetrahydrofolate cyclohydrolase

Transport of LysValPhe, Extracellular

Transport of 7Z, 10Z-Hexadecadienoic Acid into Extracellular Space

Transport of 1-Dihomo-Linolenoylglycerophosphoethanolamine (20:3, Delta 8, 11, 14)

Glycine N-methyltransferase

Excretion of 7-beta-OH-gliclazide-glucuronide into bile

Transport of 15(R)-HEPE, Extracellular Space, Active Transport

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Cytochrome P450 2C19

3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase

Hexokinase (D-glucosamine:ATP)

Efflux of cerivastatin-M1 into bile

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Deoxyribokinase

Transport of PheLysPro, Extracellular

Transport of AsntyrThr, Extracellular

Palmitoyl Coenzyme A Hydrolase

Transport of TrpGluPro, Extracellular

PCHOLLINL_HSPLA2

Formation of 1-Linoleoylglycerophosphocholine (Delta 9, 12) by Phospholipase A2

Dehydrodolichol diphosphate phosphatase (liver)

BIOMASS_reaction

Generic Human Biomass Reaction

Transport of L-Histidine with Symport of Sodium And Antiport of Proton by Snat5 Transporter

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Formation of 3-Hydroxy-3-Methyl-Glutarate

Dopamine:amet O-methyltransferase

Palmitoyl Coenzyme A Hydrolase

Transport of Pregnenolone, Extracellular

Transport of PhetyrGln, Extracellular

Thymidine Kinase

Transport of ArgCysSer, Extracellular

Methylsterol Monooxygenase

Transport of AsntyrGly, Extracellular

Transport of ThrGlntyr, Extracellular

Formation of Suberyl-Glycine

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

Transport of HisProLys, Extracellular

Efflux of 3-keto-5,6,-dihydroxy-pravastatin into bile

Taurolithocholic Acid 3-Sulfate

Efflux of acetaminophen-sulphate into hepatic vein

Transport of IleTrptyr, Extracellular

Bilirubin beta-diglucuronide transport MDR

Palmitoyl Coenzyme A Hydrolase

Conversion of lactone form of 6-beta-hydroxy-lovastatin to acid form

Transport of Lignocericyl Coenzyme A from Cytosol to Peroxisome.

Transport of MetTrpPhe, Extracellular

Fatty acyl CoA synthase n C120CoA

Formation of Mevalonate-Lactone

Transport of 14, 15-EET, Active Transport

Ornithine mitochondrial transport exchange with citruline

5-Hydroxy-L-Tryptophan Secretion via Secretory Vesicle (ATP Driven)

Transport of ProValGln, Extracellular

Aldehyde dehydrogenase (phenylacetaldehyde, NAD)

Oxidized glutathione irreversible active transport (rbc)

Transport of Cis, Cis-11, 14-Eicosadienoyl Coenzyme A, Active Transport

Deoxycholic acid 3-sulfate ABC bile acid transporter

Carbonyl Reductase (NADPH)

SPHMYLN1824_hs_ATPt

Transport of Sphingomyelin (D18:0/24:0), Active Transport

Transport (ATP-Dependent) into Extracellular Space

Transport of 11-Cis-Eicosenoate

Transport of AsntyrPhe, Extracellular

Transport of Estrone, Extracellular

GDP-L-fucose synthase

Efflux of 5-hydroxy-fluvastatin into bile for excretion into faeces

FAD diphosphatase

3-dehydro-deoxycholic acid formation

Transport of 1-Arachidonoyl-Glycero-3-Phosphocholine

Transport of Phenylpyruvate via Proton Symport

Transport of Taurodeoxycholate

6-Phosphogluconolactonase

5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

Transport of TrpMetVal, Extracellular

Transport by ABCa11 into Extracellular Space

Transport of Trans-Delta-2-Heptadecanoic Acid, Extracellular

Formation of 1-Eicosatrienoylglycerophosphoethanolamine (Delta 11, 14, 17), Lpe (20:3) by Phospholipase A2

Formation of 1-Docosahexenoylglyceroethanolamine (Delta 4, 7, 10, 13, 16, 19), Lpe (22:6) by Phospholipase A2

Lithocholic acid 3-sulfate ABC bile acid transporter

Palmitoyl Coenzyme A Hydrolase

PCHOLN183_HSPLA2

Formation of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 9, 12, 15) by Phospholipase A2

Dopamine O-Quinone Cyclization

Efflux of AM1A-cyclosporine into bile

17Alpha-Hydroxypregnenolone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

1, 2-Dihydroxy-5- (Methylthio)Pent-1-En-3-One:Oxygen Oxidoreductase (Formate-Forming)

Phosphoribosylaminoimidazole carboxylase

Transport of 15(S)-HEPE, Active Transport

Sphingosine Kinase 1

Trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Ursodeoxycholic acid sulfotransferase

Transport of 6-Trans-Leukotriene B4, Active Transport

PCHOLPALME_HSABCt

Transport of 1-Palmitoleoylglycerophosphocholine (Delta 9)

Transport of IleAsnHis, Extracellular

Transport of taurine into the intestinal cells by PAT1

Biotin uptake (antiport)

Transport of GlyLysPhe, Extracellular

L-Formylkynurenine hydrolase

Acetylcholinesterase

L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11

Transport of pristanoylcoa from cytosol to peroxisomes.

7Alpha-Hydroxycholest-4-En-3-One 12Alpha-Hydroxylase

Formimidoyltransferase cyclodeaminase reversible

Glucosaminylgalactosylglucosylceramide Beta-Galactosyltransferase

Phosphatidylcholine flippase

Phosphatidyl-CMP: glycerophosphate phosphatidyltransferase

N acetylglucosamine 6 phosphate synthase

Glycerol-3-Phosphate Acyltransferase

Transport of 17Alpha-Hydroxypregnenolone Sulfate, Extracellular

UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

Transport of ArgAlaPhe, Extracellular

Ethanolamine phosphotransferase

Efflux of glucuronide-conjugate of 3-methoxy-acetaminophen into hepatic vein

Homoserine kinase

Tryptaminium Transport, Cytosol

Transport of TrpThrtyr, Extracellular

Cytochrome P450 2C9

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

SPHMYLN18115_hs_ATPt

Transport of Sphingomyelin (D18:1/15:0), Active Transport

Lysine mitochondrial transport via ornithine carrier

Lactosylceramide 1, 3-N-Acetyl-Beta-D-Glucosaminyltransferase

Transport of PheProArg, Extracellular

PCHOLN204_HSABCt

Transport of 1-Eicosatetraenoylglycerophosphocholine (Delta 8, 11, 14, 17), Sn1-Lpc (20:4)

Secretion of Glycine via Secretory Vesicle (ATP Driven)

PCHOLSTE_HSABCt

Transport of 1-Stearoylglycerophosphocholine

Alanine transport (Na, H coupled)

Palmitoyl Coenzyme A Hydrolase

PCHOLN201_HSPLA2

Formation of 1-Eicosenoylglycerophosphocholine (Delta 11) , Sn1-Lpc (20:1) by Phospholipase A2

Glutamine synthetase

3, 4-Dihydroxyphenylethanol:NADP+ Reductase

Carbonyl reductase [NADPH] 1

Alcohol dehydrogenase glycerol NADP

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

Transport of ArgHisThr, Extracellular

N, N-Dimethylglycine:Electron-Transfer Flavoprotein Oxidoreductase (Demethylating)

Transport of CysGluTrp, Extracellular

Hydrolysis of Fatty Acyl Coenzyme A (14:1)

Transport of AsnPheCys, Extracellular

Retinal dehydrogenase

NAD synthase (nh3)

Aromatic-L-Amino-Acid Decarboxylase

UDPglucose 6-dehydrogenase

PCHLN225_HSABCt

Transport of 1-Docosahexenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16, 19), Sn1-Lpc (22:6)

Citrate reversible transport via symport

Transport of Thromboxane B2

Transport of Leukotriene B5, Active Transport

Transport (ATP-Dependent) into Extracellular Space

Hydroxylation of 2-Oxoadipate

1-Phosphatidylinositol-4-Phosphate 5-Kinase

Vitamin D3 25-hydroxylase

Transport of TrpGlyLeu, Extracellular

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Acetoacetate mitochondrial transport via H+ symport

Steroid 21-Monooxygenase

Transport of PheLeuAsp, Extracellular

3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase

Palmitoyl CoA desaturase n C160CoA n C161CoA

Transport of PhePhe, Extracellular

Transport of TrptyrGln, Extracellular

Dehydroepiandrosterone sulfotransferase

Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

3-dehydro-lithocholic acid ABC bile acid transporter

Production of Glutaryl Carnitine

Transport of Ornithine, Extracellular Space

SPHMYLN_HsATPte

Extracellular Transport of Sphingomyeline, Active Transport

Spermidine acetyltransferase (N8)

Porphobilinogen synthase

Transport of LeuTrpArg, Extracellular

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Efflux of thiomethyl-sulphoxide-acetaminophen-sulphate into hepatic vein

Retinol dehydrogenase (9-cis,NADPH)

Palmitoyl Coenzyme A Hydrolase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Sphingolipid C-4 Hydroxylase (Des2)

Riboflavin transport (ATP dependent)

Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active

S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

Transport of TrpGlyVal, Extracellular

Transport of ThrAsntyr, Extracellular

Lithocholic acid 1beta-hydroxylase

PCHOL2OLE_HSABCt

Transport of 2-Oleoylglycerophosphocholine

Alternative Route for Formation of Succinylacetone, from Fumarylacetoacetate

Cholest-5-Ene-3Beta, 7Alpha-Diol 3Beta-Dehydrogenase

Sphingosine N-Acyltransferase

Unspecific Monooxygenase

Phosphatidylserine flippase

Transport of TrpLeuVal, Extracellular

D-ribulokinase (D-ribulose)

Ursocholic acid ABC bile acid transporter

Glutamate transport via Na, H symport and K antiport

Aldehyde Dehydrogenase (NAD+)

Palmitoyl Coenzyme A Hydrolase

Linoleoyl-CoA, hydrogen-donor:oxygen oxidoreductase

Transport of ThrIleArg, Extracellular

Ethanolaminephosphotransferase

Formation of Hexanoic Acid

Beta-Aminopropion aldehyde NAD+ oxidoreductase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.7

Transport of 7Z, 10Z-Hexadecadienoic Acid into Cytosol

Inositol transport in via proton symport

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

Retinal dehydrogenase (NADPH)

Orotidine-5'-phosphate decarboxylase

Nucleoside triphosphate pyrophosphorylase (gtp)

Linoleoyl Coenzyme A, Ferrocytochrome B5:Oxygen Oxidoreductase (6, 7 Cis-Dehydrogenating)

Biotin reversible transport via proton symport, mitochondria

Glycochenodeoxycholic acid sulfotransferase

PCHOLPALME_HSPLA2

Formation of 1-Palmitoleoylglycerophosphocholine (Delta 9) by Phospholipase A2

Acetone mitochondrial transport via proton symport

Choline phosphatase

Xylose reductase

Amino acid transporter (glu-L), mitochondrial

2,3-diketo-5-methylthio-1-phosphopentane degradation reaction

PCHOLN261_HSPLA2

Formation of Lysopc A C26:1 (Delta 5) by Phospholipase A2

Taurine conjugation of S-ibuprofen

Stearoyl CoA desaturase n C180CoA n C181CoA

Phosphatidylinositol synthase (Homo sapiens)

Taurodeoxycholic acid sulfotransferase

Transport of docosapentenoylcoa into peroxisomes.

Aldehyde dehydrogenase (indole-3-acetaldehyde, NAD)

Glutathione-disulfide reductase

Palmitoyl Coenzyme A Hydrolase

3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase

Palmitoyl Coenzyme A Hydrolase

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

Transport of LysLysLys, Extracellular

DIGALSGALSIDEATPte

Extracellular Transport of Digalactosylceramidesulfate, Active Transport

Superoxide dismutase

Phosphoribosylpyrophosphate synthetase

Cysteine oxidase

Efflux of thiomethyl-sulphoxide-acetaminophen-glucuronide into hepatic vein

Sulfite oxidase

Sulfate adenylyltransferase

UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)

Glycerol kinase

Nucleoside triphosphate pyrophosphorylase (ditp)

FAOXOHC22C22DCc

Fatty Acid Omega Oxidation (W-Ohc22->C22Dc)

10-formyltetrahydrofolate:NADP+ oxidoreductase

3Beta-Hydroxy-Delta5-Steroid Dehydrogenase

Formation of 15-Keto-Prostaglandin F2A

3Beta-Hydroxysteroid-4Alpha-Carboxylate 3-Dehydrogenase (Decarboxylating)

Transport of 21-Hydroxyallopregnanolone, Extracellular

4 aminobutyrate reversible transport in via proton symport

GTP cyclohydrolase I

Secretion of Dopamine via Secretory Vesicle (ATP Driven)

Nucleoside triphosphate pyrophosphorylase (itp)

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

6-Lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2-oxidoreductase Folate biosynthesis EC:1.1.1.220

Alcohol dehydrogenase (D-1,2-propanediol)

Prostaglandin-Endoperoxide Synthase

ATP:pantetheine 4'-phosphotransferase

Lactonization of hydroxy metabolite of nifedipine in hepatocytes

Transport of SerPheLys, Extracellular

Transport of 5, 6-EET, Active Transport

Transport of 2-Methoxyestradiol-17Beta, Extracellular

Formation of Ethylmalonyl Coa

Diphosphoglyceromutase

Tetrahydrobiopterin:NADP+ oxidoreductase Folate biosynthesis EC:1.1.1.153

Transport of LysCysHis, Extracellular

Histidine mitochondrial transport via proton symport

IBUP_RCYPCARhep

Oxidation of R-3-hydroxy ibuprofen to R-carboxy ibuprofen

Conversion of 4-hydroxy-atorvastatin-lactone to its acid form in hepatocytes

Glycerate kinase

Methylsterol Monooxygenase

Transport of TrpGluGly, Extracellular

Efflux of simvastatin by P-gp from the enterocytes into lumen

NAD diphosphatase

Transport (ATP-Dependent) into Extracellular Space

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

Propane-1, 2-Diol:NAD+ 1-Oxidoreductase

Nicotinamide-nucleotide adenylyltransferase

N-Acetyllactosaminide Beta-1, 3-N-Acetylglucosaminyltransferase

Efflux of alpha-Tocopherol into the lyphatics in chylomicrons

Inositol-tetrakisphosphate 1-kinase

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Excretion of 6-alpha-OH-gliclazide into bile

3-sulfino-alanine transaminase (irreversible)

Dopamine 3-O-Glucuronidation

Transport of GlnLysLys, Extracellular

PCHOLN2254_HSPLA2

Formation of 1-Docosapentenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16), Sn1-Lpc (22:5)-W6 by Phospholipase A2

Transport of LeuAsnAsp, Extracellular

Transport of CysGlnMet, Extracellular

Steryl-Sulfatase

Efflux of 12-hydroxy tacrolimus into intestinal lumen by ABC transporter

Deoxyadenosine deaminase

3Beta-Hydroxy-Delta5-Steroid Dehydrogenase

Transport of GluThrLys, Extracellular

Transport of ProHis, Extracellular

Transport of Lipoxin B4, Proton Symport

Palmitoyl Coenzyme A Hydrolase

5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of SerGlyGlu, Extracellular

PCHOLHEP_HSABCt

Transport of 1-Heptadecanoylglycerophosphocholine

Transport of IleGlnGlu, Extracellular

Glycolysis / Glyconeogenesis EC:2.7.1.1

Transport of Phenyl Lactate

Leukotriene-B4 20-Monooxygenase

Transport of CystyrAsn, Extracellular

Transport of 2-Hydroxyestrone, Extracellular

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Ursodeoxycholic acid 3-sulfate ABC bile acid transporter

Thioredoxin (ubiquinone 10) reductase (NADPH)

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

Carbamoyl-phosphate synthase (glutamine-hydrolysing)

Transport of stearidonylcoa into peroxisomes.

Transport of LeuAlaArg, Extracellular

Transport of GlntyrLeu, Extracellular

Transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Efflux of 6-hydroxy-fluvastatin into bile for excretion into faeces

Sodium proton antiporter (H:NA is 1:1)

Efflux of 6-beta-hydroxy simvastatin acid into bile

Linoleate 13S-Lipoxygenase

Pyrophasphatase (dephospho-CoA)

Transport of HisLysVal, Extracellular

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

Transport of MetPheArg, Extracellular

Alcohol Dehydrogenase

Transport (ATP-Dependent) into Extracellular Space

Transport of 2-Methoxyestrone, Extracellular

Transport of 1-Alkyl 2-Acteylglycerol 3-Phosphocholine

Nadh biliverdin reductase

Transport of ValLystyr, Extracellular

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Trans-2-enoyl-CoA reductase (18:0) (NADPH)

BIOMASS_maintenance

Biomass maintenance reaction without replication precursors

Transport of 17Alpha-Hydroxypregnenolone, Extracellular

Transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Steroyl Coenzyme A, Hydrogen-Donor:Oxygen Oxidoreductase Polyunsaturated Fatty Acid Biosynthesis

Ethanolamine kinase

Transport of ProTrpLys, Extracellular

Formation of Phenyl-Lactate

2HATVACIDGLUCteb

Efflux of 2-hydroxy-atorvastatin-acyl-glucuronide into bile

Palmitoyl Coenzyme A Hydrolase

Proton transport, Golgi

Formation of Glycoursodeoxycholate

Folylpolyglutamate Synthetase (Dhf)

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of AspValAsn, Extracellular

Fatty-acid-CoA thioesterase (hexanoate)

AHANDROSTANGLCte

Glucuronidated compound transport

Transport of LysGlnPhe, Extracellular

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Glycine hydroxymethyltransferase

Xanthine dehydrogenase

PCHOLN15_HSABCt

Transport of 1-Pentadecanoylglycerophosphocholine, Sn1-Lpc (15:0)

Folate Transport by ABCa11

Uptake of atorvastatin by enterocytes by MCT1

Cytochrome P450 2C9

(R)-4-Hydroxyphenyllactate Dehydrogenase

Efflux of 5,6-epoxy-3-alpha-iso-pravastatin into bile

Release of 3-hydroxy-lovastatin acid form into bile

Glyceraldehyde-3-phosphate dehydrogenase

R group coenzyme a ligase

Formation of 1-Arachidonoyl-Glycero-3-Phosphocholine by Phospholipase A2

Dihydrofolate reductase

Acetyl-CoA:aralkylamine N-acetyltransferase

Folylpolyglutamate synthetase (10fthf)

Transport of Myo-Inositol 1-Phosphate, Proton Symport

Thiamin pyrophosphatase

3MOX4HOXPGALDOX

3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase

Uroporphyrinogen Decarboxylase

6,7-dihydropteridine reductase

Catechol O-Methyltransferase

Pyruvate kinase

Guanosine transport in via proton symport

Adenosylmethionine decarboxylase

Glutathione synthetase

Estrone-Sulphate Transport by ABCa11

Phylloquinone transport

Phospholipase D

Stearoyl Coenzyme A 9-Desaturase

Transport of TyrCysGly, Extracellular

Potassium transport out via proton antiport

Transport of HisTrpHis, Extracellular

Dopamine 4-O-Glucuronide Transport

Efflux of 6-beta-hydroxy-methyl-simvastatin-acid into bile

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Efflux of AM1c-cyclosporine into bile

Dihydroceramide desaturase

Fatty acyl CoA synthase n C100CoA

Transport of 5Alpha-Androstane-3, 17-Dione, Extracellular

Transport of TrpProVal, Extracellular

Transport of TrpGlutyr, Extracellular

Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

Transport of Phenylpyruvate via Proton Symport, Mitochondrial

PCHOLOLE_HSPLA2

Formation of 1-Oleoylglycerophosphocholine (Delta 9) by Phospholipase A2

Delta14-Sterol Reductase

Efflux of AM1-cyclosporine into bile

Globoside Alpha-N-Acetylgalactosaminyltransferase

Glucuronidated bile acid excretion (HDCA-6G)

Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17

Formation of Tauroursodeoxycholate

Metabolism (Formation/Degradation) of ProHistyr

PCHOLDET_HSPLA2

Formation of 1-Eicosatrienoylglycerophosphocholine (Delta 11, 14, 17) by Phospholipase A2

Phosphatidate cytidylyltransferase

Steryl-sulfatase

Uridine kinase (GTP:Uridine)

Transport of TyrCysThr, Extracellular

Serotonin Transport by Ent4

Aldehyde dehydrogenase (phenylacetaldehyde, NADP)

Riboflavin kinase

Transport of 1-Palmitoylglycerophosphocholine

Pantothenate kinase

Transport of TrpValAsp, Extracellular

Conversion of 6-beta-hydroxy simvastatin lactone to acid form

Dopamine 4-O-Sulfotransferase

Bilirubin monoglucuronide transport MDR

Steryl-Sulfatase

Thiamine-triphosphatase

7-Dehydrocholesterol Reductase

Aldose reductase

Metabolism (Formation/Degradation) of LysArgLeu

L-Arabinitol 4-Dehydrogenase

Methylsterol Monooxygenase

Ascorbic Acid Oxidase

Efflux of AM4N-cyclosporine into bile

Transport of 12 Hydroxy Arachidonic Acid, Extracellular Space, Active Transport

Nucleoside diphosphatase ADP

Sphingomyelin Phosphodiesterase

L-aminoadipate-semialdehyde dehydrogenase (NADH)

3',5'-cyclic-nucleotide phosphodiesterase

Phosphatidylinositol-5-phosphate 4-kinase

Transport of 21-Hydroxypregnenolone, Active Transport

Transport of AsnCysCys, Extracellular

Transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Spermidine acetyltransferase

D sorbitol reductase

Efflux of 31-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

Sphingomyelinase

Conjugation of cyclosporine with sulphate for excretion in hepatocytes

PCHOLDEIC_HSPLA2

Formation of 1-Eicosadienoylglycerophosphocholine (Delta 11, 14) by Phospholipase A2

Folylpolyglutamyl Synthetase

D-proline reversible transport via proton symport

Stearoyl Coenzyme A 9-Desaturase

Transport of CysAsnMet, Extracellular

S-Adenosyl-L-methionine:catechol O-methyltransferase

Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

Efflux of pravastatin glucuronide into bile

Transport of L-Threonate by Active Transport

Transport of AlaArgGly, Extracellular

34DHXMANDACOX_NADP

3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

Galactose 1 phosphate uridylyltransferase

3-Mercaptolactate:NAD+ oxidoreductase irreversible

Palmitoyl Coenzyme A Hydrolase

Taurodeoxycholic acid 3-sulfate ABC bile acid transporter

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Steroid, Reduced-Adrenal-Ferredoxin:Oxygen Oxidoreductase (11-Hydroxylating)

Fatty acyl CoA synthase n C180CoA

Alcohol dehydrogenase (L-lactaldehyde)

Retinol dehydrogenase (9-cis,NADH)

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

3 (Or 17)Alpha-Hydroxysteroid Dehydrogenase

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

Choline dehydrogenase

4HOXPACDOX_NADP

4HOXPACDOX LPAREN NADP RPAREN

Efflux of 15, 31-O-Didesmethyl-tacrolimus into bile

Excretion of 6-beta-OH-gliclazide-glucuronide into bile

PCHOLN204_HSPLA2

Formation of 1-Eicosatetraenoylglycerophosphocholine (Delta 8, 11, 14, 17), Sn1-Lpc (20:4) by Phospholipase A2

Pravastatin efflux into lumen for excretion into feces

Transport of ValProTrp, Extracellular

L-lactate dehydrogenase

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Cholic acid 3-sulfate ABC bile acid transporter

FAOXOHC16C16DCc

Fatty Acid Omega Oxidation (W-Ohc16->C16Dc)

Efflux of pitavastatin by BCRP from the enterocytes into lumen

Transport of 11-Cis-Eicosenoate, Active

Thymidine kinase (ATP:thymidine)

Cytochrome P450 2C8

Dolichyl-Diphosphate Phosphohydrolase

Transport of LysArgLeu, Extracellular

Deoxycytidine kinase

Taurochenodeoxycholic acid sulfotransferase

Phospholipase D

Cytochrome P450 2C9

Transport of GluArgLeu, Extracellular

Formation of 7-Hydroxy-Octanoate

ADPribose diphosphatase

Transport of GluMet, Extracellular

Transport of ArgLeuPhe, Extracellular

Transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

2,3-dioxo-L-gulonate:hydrogen peroxide oxireductase

D-glucose transport in via proton symport

Fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)

PCHOLMYR_HSPLA2

Formation of 1-Myristoylglycerophosphocholine by Phospholipase A2

Carbonyl Reductase (NADPH)

Formation of 1-Heptadecanoylglycerophosphoethanolamine (C17:0 Pe) by Phospholipase A2

Folylpolyglutamate synthetase

Transport of ThrThrArg, Extracellular

Methylsterol Monooxygenase

L lactate transport mitochondrial

Formaldehyde dehydrogenase

Palmitoyl Coenzyme A Hydrolase

3',5'-cyclic-nucleotide phosphodiesterase

Transport of PheTrpLeu, Extracellular

Transport of W-Hydroxyl Arachidonic Acid, Active Transport

SPHMYLN18122_hs_ATPt

Transport of Sphingomyelin (D18:1/22:0), Active Transport

Transport of AspGluTrp, Extracellular

Efflux of 13,15-O-didesmethyl tacrolimus into intestinal lumen by ABC transporter

Sodium proton antiporter HNA is 11

Phosphatidylethanolamine flippase

Alcohol dehydrogenase (ethanol)

Phosphatidylinositol 3-kinase

Fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)

Phospholipase D

17-beta-D-glucuronide transport (ATP-dependent)

Transport (ATP-Dependent) into Extracellular Space

3-Methoxytyramine secretion via secretory vesicle (ATP driven)

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Transport of GlnAsnGln, Extracellular

Transport of Tyrtyr, Extracellular

5ADTSTSTERONEGLCte

Glucuronidated compound transport

Transport of HisArgSer, Extracellular

Desmosterol reductase

Transport of GlnTrpGlu, Extracellular

Carbonyl Reductase (NADPH)

Glucuronidated bile acid excretion (HDCA-24G)

Fatty-acid-CoA thioesterase (dodecanoate)

Transport of HisGlu, Extracellular

Acetone monooxygenase

6-phosphogluconolactonase

Palmitoyl Coenzyme A:L-Carnitine O-Palmitoyltransferase

Steryl-Sulfatase

3,4-Dihydroxyphenylacetate:amet O-methyltransferase

Transport of Nicotinate

Alcohol Dehydrogenase

Release of iboprofen acyl glucuronides into the portal blood

Testosterone sulfotransferase

Formyl coa hydrolase

Steryl-sulfatase

Transport of Glycylproline by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Transport of 1-Stearoylglycerophosphoethanolamine

Transport of TrpIleLys, Extracellular

Formation of 1-Hexadecenoylglycerophosphoethanolamine (C16:1 Pe, Delta 9) by Phospholipase A2

Unspecific Monooxygenase

Beta-ureidopropionase (D-3-amino-isobutanoate forming)

3 Dehydrosphinganine reductase

SPHMYLN18118_hs_ATPt

Transport of Sphingomyelin (D18:1/18:0), Active

Alcohol dehydrogenase (methanol)

Nicotinate-mononucleotide adenylyltransferase

Acetylcholine Secretion via Secretory Vesicle (ATP Driven)

ATP:cytidine 5'-phosphotransferase

Transport of ThrPheArg, Extracellular

Transport of 7, 10, 13-Hexadecatrienoic Acid into Cytosol

Nitric Oxide Synthase (NO forming)

Formation of Methyl-Succinate

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Transport of AsnPheAsp, Extracellular

Alternative Route for Formation of Succinylacetone, from Maleylacetoacetate

Transport of ArgProThr, Extracellular

Efflux of AM1AL-cyclosporine into bile

Formation of 1-Linoleoylglycerophosphoethanolamine (Delta 9, 12) by Phospholipase A2

Hydroxypyruvate Reductase (NADH)

3-dehydrocholic acid formation

Transport of TrpGlnGln, Extracellular

Iodide:hydrogen-peroxide oxidoreductase 2

N4 AcetylaminobutanalNAD oxidoreductase

Nicotinate D-ribonucleotide synthase (ATP)

Stearoyl Coenzyme A 9-Desaturase

Transport of MetGlntyr, Extracellular

Stearoyl Coenzyme A 9-Desaturase

Triiodothyronine Sulfotransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Nad(p)h biliverdin reductase

3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

L lactate reversible transport via proton symport

Fatty-acid-CoA thioesterase (hexadecanoate)

Phosphate reversible transport via symport

Fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)

Active Transport of Tetradecenoate (N-C14:1)

3-mercaptolactate:cysteine reductase

Transport of AlaHisAla, Extracellular

Dihydrosphingosine N-acyltransferase

Release of 3-hydroxy-iso-delta-4,5-hydroxy acid form of lovastatin into bile

Adenine deaminase

Transport of TrpAspAsp, Extracellular

Uroporphyrinogen decarboxylase (uroporphyrinogen III)

Phosphatidylinositol 3-phosphate 5-kinase

Transport of IleGlyArg, Extracellular

SPHMYLN181221_hs_ATPt

Transport of Sphingomyelin (D18:1/22:1), Active

Oxidation of nifepine to nitropyridine metabolite in hepatocytes

Glycolysis / Glyconeogenesis EC:2.7.1.1

R group coenzyme a ligase

Formation of 21-Hydroxypregnenolone

17Beta-Estradiol 3-Glucosiduronic Acid Transport by ABCa8

Transport of ProProPro, Extracellular

Efflux of AM9-cyclosporine into bile

Transport of Glycerol-2-Phosphate

Glucuronidated bile acid excretion (CDCA-24G)

Transport of TyrThr, Extracellular

Uptake of acetaminophen by the hepatocytes

3Beta-Hydroxysteroid 3-Dehydrogenase

Transport of HisMetGln, Extracellular

Very-Long-Chain Enoyl Coenzyme A Reductase

Transport of Trans, Cis, Cis-2, 11, 14-Eicosatrienoic Acid

Aldose reductase (methylglyoxal)

Efflux of 4-hydroxy-atorvastatin-acid into bile

Proton diffusion

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Galactoside 2-Alpha-L-Fucosyltransferase

Adenosine monophosphate deaminase

4-aminobutyrate reversible transport in via proton symport (lysosome)

ADPmannose diphosphatase

Dephospho-CoA kinase

Glycerol 3 phosphate dehydrogenase NAD

Efflux of losartan by P-gp from the enterocytes into lumen

Transport of ArgArg, Extracellular

Formation of 1-Tridecanoylglycerophosphoethanolamine (C13:0 Pe) by Phospholipase A2

Transport of ArgAlaThr, Extracellular

Glycocholic acid sulfotransferase

Aminomuconate-semialdehyde dehydrogenase

Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD

Long-Chain-Fatty-Acid Coenzyme A Ligase

Transport of PheThrLys, Extracellular

Formation of Ethylmalonic Acid

Cytochrome P450 2E1

ABC transporter

Folylpolyglutamate synthetase (DHF)

Cytidine kinase (GTP)

Transport of Lathosterol, Energy Dependant

(N-Acetylneuraminyl)-Galactosylglucosylceramide N-Acetylgalactosaminyltransferase

Lactosylceramide 4-alpha-galactosyltransferase

NADP nucleosidase

Transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Transport of 1-Oleoylglycerophosphoethanolamine (Delta 9)

Transport of MetArgLeu, Extracellular

Phosphatidylinositol phospholipase C

Transport of HisLysAla, Extracellular

Delta14-Sterol Reductase

S-Adenosyl-L-Methionine:Sarcosine N-Methyltransferase

Guanosine aminohydrolase EC:3.5.4.15

Transport of GluTrpAla, Extracellular

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

Fatty acid synthase n C180

D-lactate dehydrogenase

Proline oxidase L proline NAD

5ADTSTSTERONESULT

5alpha-Dihydrotestosterone sulfotransferase

Transport of ArgArgMet, Extracellular

Formation of 1-Oleoylglycerophosphoethanolamine (Delta 9) by Phospholipase A2

5 diphosphoinositol 1 2 3 4 6 pentakisphosphate diphosphohydrolase

Formation of 3-Methyl-Glutarate

Xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

L-Lactate dehydrogenase, cytosolic/mitochondrial

Hexokinase (D-fructose:ATP)

Holocarboxylase synthestase (biotin protein ligase)

Efflux of acetaminophen-glutathione-conjugate from enterocytes into portal blood

UDP-N-acetylglucosamine diphosphorylase

PCHOLSTE_HSPLA2

Formation of 1-Stearoylglycerophosphocholine by Phospholipase A2

Uptake of allopurinol by the enterocytes

S-Adenosyl-L-methionine:catechol O-methyltransferase

Transport of Cis-5, 8-Tetradecadienoic Acid, Active Transport

11Beta-Hydroxyprogesterone, Hydrogen-Donor:Oxygen Oxidoreductase (21-Hydroxylating)

Transport of ValSerArg, Extracellular

Formation of 7-Ketolithocholate

PCHOLEIC_HSABCt

Transport of 1-Eicosadienoylglycerophosphocholine (Delta 11, 14)

L-Phenylalanine carboxy-lyase

Glucose 6-Phosphate Dehydrogenase

Aspartate-glutamate mitochondrial shuttle

Transport of TyrValMet, Extracellular

Leukotriene-B4 20-Monooxygenase

Cytosine deaminase

Transport of GluMetHis, Extracellular

Transport of 16Alpha-Hydroxydehydroepiandrosterone, Extracellular

4-Pyridoxal secretion

PCHOLN1836_HSPLA2

Formation of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 6, 9, 12) by Phospholipase A2

Fatty-acyl-CoA elongation (n-C20:4CoA)

Transport of PhePheAsn, Extracellular

Efflux of 3,5-dihydrodiol-simvastatin-lactone form into bile

Palmitoyl Coenzyme A Hydrolase

Phosphoribosylaminoimidazole synthase

Palmitoyl Coenzyme A Hydrolase

Transport by Monocarboxylate Transporter-2 into Extracellular Space

ABC bile acid transporter

Transport of L-Ascorbate by SVCT1 or SVCT2 transporter

D lactate transport via proton symport

Carbonyl Reductase (NADPH)

Transport of CysLeuThr, Extracellular

Metanephrine secretion via secretory vesicle (ATP driven)

Transport reaction

3Beta-Hydroxysteroid 3-Dehydrogenase

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Phospholipase D

Hydroxylation of 3- (3-Hydroxyphenyl)Propionate

L-Normetanephrine seceretion via secretory vesicle (ATP driven)

Sn-Glycero-3-Phosphocholine Cholinephosphohydrolase

Carbonyl Reductase (NADPH)

Delta4-3-Oxosteroid 5Beta-Reductase

Transport of CysSerMet, Extracellular

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Transport of GlyHisAsn, Extracellular

3Beta-Hydroxysteroid-4Alpha-Carboxylate 3-Dehydrogenase (Decarboxylating)

Phosphopantothenoylcysteine decarboxylase

Aldehyde dehydrogenase (acetaldehyde, NADP)

Biotin acetyl CoA carboxylase ligase

Formation of 1-Didecanoylglycerophosphoethanolamine (C12:0 Pe) by Phospholipase A2

Glycogenin self-glucosylation

Efflux of desacyl dehydro-pravastatin into bile

Stearoyl Coenzyme A 9-Desaturase

Fumarylacetoacetase

Picolinic acid decarboxylase

Transport of 3-Ureidopropionate

Glycocholic acid 3-sulfate ABC bile acid transporter

3-dehydro-lithocholic acid formation

Transport (ATP-Dependent) into Extracellular Space

Sphingosine kinase

Conversion of 6-beta-carboxy simvastatin lactone to acid form

Transport of Androst-4-Ene-3, 17-Dione, Extracellular

Nucleotide phosphatase

Transport of TrpGluLeu, Extracellular

Transport of 14, 15-DIHETE, Active Transport

Transport of TrpArgAla, Extracellular

Butyrate mitochondrial transport via proton symport, reversible

Band membrane protein-methyltransferase

Coprostanol ABC bile acid transporter

Very-Long-Chain Enoyl Coenzyme A Reductase

Transport of ArgValCys, Extracellular

Dehydrodolichol reductase (liver)

Transport of AspHisPro, Extracellular

Taurocholic acid 3-sulfate ABC bile acid transporter

Uridine kinase (ITP:Uridine)

Apocarboxylase formation

Transport of AspGluPro, Extracellular

Efflux of sulphate-thiomethyl-acetaminophen conjugate into hepatic vein

Fatty acid omega-hydroxylase

Prostaglandin-F Synthase

Transport of GluIleLys, Extracellular

Malonyl-CoA Decarboxylase cytoplasmic

Transport of ArgAlaAla, Extracellular

Active Transport of 8-Dehydrocholesterol

Transport of TyrArgGlu, Extracellular

Thiamine transport in via proton symport, mitochondrial

Release of 6-exomethylene-lovastatin-acid form into bile

Carbonyl Reductase (NADPH)

Transport of ValVal, Extracellular

Dihydrothymin dehydrogenase (NADP)

Deoxycytidine deaminase

Transport of PheAsnMet, Extracellular

Steroid, Hydrogen-Donor:Oxygen Oxidoreductase (17-Alpha-Hydroxylating)

Ganglioside Galactosyltransferase

Formation of Methyl-Histidine

Ceramide kinase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

H transporter, peroxisome

Beta-Galactoside Alpha-2, 3-Sialyltransferase

Inosine transport in via proton symport

Transport of ValTrpPhe, Extracellular

3-(3-hydroxyphenyl)propionate transport via proton symport, reversible

Transport of ArgGluGlu, Extracellular

Very-Long-Chain Enoyl Coenzyme A Reductase

Transport of GlyValHis, Extracellular

Glycolysis / Glyconeogenesis EC:2.7.1.1

Arachidonate 5-Lipoxygenase

ATP Creatine kinase (c)

Deamino-NAD+ nucleotidohydrolase

Palmitoyl Coenzyme A Hydrolase

Aldehyde Dehydrogenase (NAD+)

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Cholesterol:NADP+ Delta7-Oxidoreductase

Efflux of 3-S-hydroxy-pravastatin into bile

3Beta-Hydroxy-Delta5-Steroid Dehydrogenase

Transport of ProLeuArg, Extracellular

Efflux of glucuronide-thiomethyl-acetaminophen conjugate into hepatic vein

UDP-Glucuronosyltransferase (UGT) cytosolic (hyodeoxycholic acid)

Transport of HisHisLys, Extracellular

Thioredoxin reductase (NADPH)

Acetate mitochondrial transport via proton symport

Steroid 17Alpha-Monooxygenase

Prostaglandin-Endoperoxide Synthase

Ganglioside Galactosyltransferase

Excretion of dehydro-gliclazide into bile

PCHOLN2254_HSABCt

Transport of 1-Docosapentenoylglycerophosphocholine (Delta 4, 7, 10, 13, 16), Sn1-Lpc (22:5)-W6

Transport of IleAsp, Extracellular

Transport of Cholesta-5, 7-Dien-3Beta-Ol, Active Transport

Transport of LeuTrp, Extracellular

Propane-1,2-diol:NADP+ 1-oxidoreductase

Transport of AlaArgCys, Extracellular

Efflux of acetaminophen-mercapturate-conjugate from enterocytes into portal blood

Transport of LeuSerTrp, Extracellular

Hyaluronan synthase

3 (Or 17)Alpha-Hydroxysteroid Dehydrogenase

Diacylglycerol phosphate kinase (homo sapiens)

Lactosylceramide Alpha-2, 3-Sialyltransferase

Formation of 1-Dihomo-Linolenoylglycerophosphoethanolamine (20:3, Delta 8, 11, 14) by Phospholipase A2

Transport of 11-Deoxycorticosterone, Extracellular

Transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Very-Long-Chain Enoyl Coenzyme A Reductase

Transport of SerCysArg, Extracellular

Delta4-3-Oxosteroid 5Beta-Reductase

Cytochrome P450 2C18

Palmitoyl Coenzyme A Hydrolase

S-Adenosyl-L-Methionine:Phosphatidylethanolamine N-Methyltransferase

Dopamine 3-O-Glucuronide Transport

Transport of LystyrIle, Extracellular

Very-Long-Chain Enoyl Coenzyme A Reductase

1-Acylglycerol-3-Phosphate O-Acyltransferase 1

Hydrolysis of ibuprofen-CoA in hepatocytes

Transport of MetAsntyr, Extracellular

Transport of ProArgCys, Extracellular

3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

Formation of 5-Hydroxy-Hexanoate

Formation of 1-Arachidonoyl-Sn-Glycero-3-Phosphoethanolamine by Phospholipase A2

Transport of ArgLysAsp, Extracellular

Carbonyl Reductase (NADPH)

PCHOLDOC_HSABCt

Transport of 1-Docosahexaenoylglycerophosphocholine

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Serine transport (Na, H coupled)

Taurochenodeoxycholic acid 3-sulfate ABC bile acid transporter

Sulphation of thiomethyl-acetaminophen conjugate in hepatocytes

PCHOLHEP_HSPLA2

Formation of 1-Heptadecanoylglycerophosphocholine by Phospholipase A2

Very-Long-Chain Enoyl Coenzyme A Reductase

L-carnitine outward transport (H+ antiport)

Efflux of 6-beta-carboxy-simvastatin-acid form into bile

Quinolinate Synthase Eukaryotic

Transport of ArgtyrVal, Extracellular

H transporter, endoplasmic reticulum

Bile Acid-CoA:Amino Acid N-Acyltransferase

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Transport of ThrSerArg, Extracellular

Transport of GlnLysTrp, Extracellular

R group coenzyme a ligase

Cholesterol efflux (ATP depedent)

Transport of 11-Deoxycortisol, Extracellular

Transport of 7-Ketolithocholate, Active Transport

Palmitoyl Coenzyme A Hydrolase

Argininosuccinate synthase

Inorganic diphosphatase

Bile Acid Transport by ABCa8

CTP synthase (glutamine)

Transport of TrpThrIle, Extracellular

Catechol O-Methyltransferase

Pyruvate kinase(2)

Catechol O-Methyltransferase

Xylulose reductase

Transport of Stearoyl-CoA from cytosol to peroxisomes

Formation of 1-Pentadecanoylglycerophosphoethanolamine (C15:0 Pe) by Phospholipase A2

7Alpha-Hydroxycholest-4-En-3-One 12Alpha-Hydroxylase

Transport of TrpSertyr, Extracellular

De-lactonization of cerivastatin-M31 to cerivastatin-M23 in hepatocytes

Hydroxypyruvate reductase (NADPH)

Phosphatidylinositol 4,5-bisphosphate phospholipase C

Transport of W-Carboxy Leukotriene B4, Active Transport

Very-Long-Chain Enoyl Coenzyme A Reductase

Transport of ArgPheArg, Extracellular

Active transport

3Beta-Hydroxysteroid 3-Dehydrogenase

Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

IMP dehydrogenase

Transport of Oxaloacetate, Proton Symport

Adenylosuccinate synthase

Efflux of AM1c9-cyclosporine into bile

Transport of MetGlyArg, Extracellular

Transport of 1-Hexadecenoylglycerophosphoethanolamine (C16:1 Pe, Delta 9)

DUTP:cytidine 5'-phosphotransferase

Transport of MetMetIle, Extracellular

B-ketoacyl synthetase (palmitate, n-C16:0)

Quinine 3-Monooxygenase

Tauroursodeoxycholic acid sulfotransferase

(R)-3-Hydroxybutanoate transport via H+ symport

Methionine Decarboxylase

DHCHOLESTANATEATP

Transport of 3Alpha, 7Alpha-Dihydroxy-5Beta-Cholestanate, Active Transport

Transport of ValHisAsn, Extracellular

4-methyl-2-oxopentanoate mitochondrial transport via proton symport

Transport of ProProArg, Extracellular

Acetol monooxygenase

Glycodeoxycholic acid sulfotransferase

Stearoyl Coenzyme A 9-Desaturase

Leukotriene-B4 20-Monooxygenase

N-acetylneuraminate proton symport

SPHMYLN18117_hs_ATPt

Transport of Sphingomyelin (D18:1/17:0), Active

Transport of HisMet, Extracellular

Conversion of 3-hydroxy-lovastatin lactone to acid form

L-glutamate secretion via secretory vesicle (ATP driven)

Adenylyl-sulfate kinase

Transport of HisGlyLys, Extracellular

Demethylation of cyclosporine to AM4N in hepatocytes

Deoxyguanosine kinase

Glucuronolactone reductase

4-Hydroxybenzoyl Coenzyme A Hydrolase

Methylsterol Monooxygenase

Transport of ThrHisHis, Extracellular

Efflux of cerivastatin by P-gp or BCRP from the enterocytes into lumen

Transport of TyrLeuArg, Extracellular

Formation of Vanil-Lactate

Pyruvate mitochondrial transport via proton symport

Methylsterol Monooxygenase

ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

Deoxyuridine kinase (ATP:Deoxyuridine)

Transport of HisAsp, Extracellular

Alternative Route for Formation of Succinylacetone, from Succinyl-Acetoacetate

3Beta-Hydroxy-Delta5-Steroid Dehydrogenase

Cys-Gly transport in via proton symport

Spermidine synthase

Efflux of cyclosporine by P-gp from the enterocytes into lumen

Unspecific Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Lactaldehyde dehydrogenase

Efflux of acetaminophen-glucuronide-conjugate from enterocytes into portal blood

Imidazolonepropionase

3-dehydro-deoxycholic acid ABC bile acid transporter

Transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

L proline reversible transport via proton symport

Transport of 2-Hydroxyestradiol-17Beta, Extracellular

Phospholipase A2

N-Acylsphingosine Galactosyltransferase

Malate dehydrogenase

UDP-Alpha-D-Galactose:Sphingosine 1-Beta-Galactosyltransferase

Transport of PheSerTrp, Extracellular

Phosphatidylinositol 5-kinase

Guanidinoacetate N-methyltransferase (c)

FAOXOHMC10DC10c

Fatty acid omega oxidation(w-OHMC10-->DC10)c

Heme Transport by ABCg2

Transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

SPHMYLN181161_hs_ATPt

Transport of Sphingomyelin (D18:1/16:1), Active Transport

Glycodeoxycholate Amidohydrolase

Transport of GlnHisLys, Extracellular

Export Mediated by ATP Binding Cassette (ABC) Transporters

Aldehyde Dehydrogenase (NAD+)

PCHOLN24_HSPLA2

Formation of 1-Lignocericylglycerophosphocholine (24:0), Lysopc A C24 by Phospholipase A2

Transport of HisGlnAla, Extracellular

3-Sulfino-L-alanine carboxy-lyase

Palmitoyl Coenzyme A Hydrolase

Transport of AsnAsnArg, Extracellular

Efflux of cerivastatin-M23 into bile

Lathosterol, NADPH:oxygen 5-oxidoreductase

Sterol 14Alpha-Demethylase

D-Glyceraldehyde dehydrogenase

PCHOLN224_HSABCt

Transport of 1-Docosatetraenoylglycerophosphocholine (Delta 7, 10, 13, 16), Sn1-Lpc (22:4)

Histamine Secretion via Secretory Vesicle (ATP Driven)

Transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Transport of GlytyrLys, Extracellular

Alcohol dehydrogenase (D-lactaldehyde)

Transport of ThrGlnGlu, Extracellular

D-arabinitol transport in via proton symporter

Retinyl ester hydrolase (11-cis)

3-Methyl-2-oxopentanoate mitochondrial transport via proton symport

Transport of 1-Tridecanoylglycerophosphoethanolamine (C13:0 Pe)

5-Hydroxy-L-tryptophan decarboxy-lyase

Palmitoyl Coenzyme A Hydrolase

Dolichol kinase, human (liver)

Phosphatidylinositol 3,4-bisphosphate 5-kinase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Biotin Transport via Sodium Symport

Transport of 1-Heptadecanoylglycerophosphoethanolamine (C17:0 Pe)

Transport of ProPhe, Extracellular

Phosphatidylinositol 4,5-bisphosphate 3-kinase

Biliary excretion of ibuprofen from hepatocytes

Transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.

Phosphoglycerate dehydrogenase

Transferred to 1.3.1.30 And 1.3.1.22

Ornithine Decarboxylase

3-mercaptopyruvate sulfurtransferase

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of 7Alpha-Hydroxycholest-4-En-3-One, Active Transport

Acylglycerol Kinase

Glycogen synthase (ggn -> glygn1)

Transport of 5Alpha-Androstane-3, 17-Dione, Endoplasmatic Reticulum

Thymidine transport in via proton symport

Retinol dehydrogenase (11-cis,NADPH)

Transport of 1-Linoleoylglycerophosphoethanolamine (Delta 9, 12)

Transport of ValLeuPhe, Extracellular

Fatty-acid-CoA thioesterase (octadecanoate)

Phosphoribosylglycinamide formyltransferase

Thiamine exit from the neterocytes

NADH:Ferricytochrome-B5 Oxidoreductase

N1-Methylnicotinamide transport

Transport of Lipoamide, Mitochondrial

3 hydroxyanthranilate 3 4 dioxygenase

Transport of PheLysAla, Extracellular

Demethylation of AM9 to AM4N9 in hepatocytes

B-ureidopropionase

Palmitoyl Coenzyme A Hydrolase

Transport of Lithocholate, Active Transport

Transport of 9 (10)-Epome, Active Transport

L-Histidine:4-Aminobutanoate Ligase (AMP-Forming)

Formimidoyltransferase cyclodeaminase

Hydrolysis of Trans, Cis, Cis-2, 11, 14-Eicosatrienoyl Coenzyme A to Trans, Cis, Cis-2, 11, 14-Eicosatrienoic Acid

Excretion of carboxy-gliclazide into bile

25/26-Hydroxycholesterol 7Alpha-Hydroxylase

Glucuronidated compound transport

Methylsterol Monooxygenase

Transport (ATP-Dependent) into Extracellular Space

Aminobutyraldehyde dehydrogenase

Transport of CysGluHis, Extracellular

Transport of 5Alpha-Pregnane-3, 20-Dione, Extracellular

Dt-Diaphorase: NADP Quinone Oxireductase

Transport of Trans-Delta-2-Heptadecanoic Acid, Mitochondrial

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Conversion of 3-hydroxy simvastatin lactone to acid form

Sterol 14Alpha-Demethylase

Glucuronidated compound transport

Tyramine Sulfotransferase

Alcohol Sulfotransferase

Unspecific Monooxygenase

PCHOL2STE_HSABCt

Transport of 2-Stearoylglycerophosphocholine

Efflux of simvastatin dihydroxy acid form into bile

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

L-aspartate transport via Na, H symport and K antiport

Zinc (Zn2+)-Iron (Fe2+) Permease (Zip), Tcdb:2.A.55.2.3

Aldehyde dehydrogenase (acetaldehyde, NAD)

NAD nucleosidase

Fatty acyl CoA synthase n C140CoA

Efflux of AM1A4N-cyclosporine into bile

Transport of GluThr, Extracellular

Phosphoethanolamine cytidyltransferase

Iron (II) transport

Palmitoyl Coenzyme A Hydrolase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

C 3 sterol dehydrogenase 4 methylzymosterol

Desaturation of Myristic Acid to 9-Tetradecenoic Acid

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

3-Amino-Isobutyrate Transport, Proton Symport

Transport (ATP-Dependent) into Extracellular Space

34DHPLACOX_NADP

34DHPLACOX LPAREN NADP RPAREN

Mannose 1 phosphate guanylyltransferase

Methylsterol Monooxygenase

Sterol 14Alpha-Demethylase

Steroid Delta-Isomerase

Transport of 13-Docosenoylcoa into Peroxisomes

Methionine synthase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

FACOAE1839Z12Z15Z

Alpha-Linolenoyl-CoA hydrolase (18:3(9Z,12Z,15Z))

Transport of 12S-HHT, FATP

Asparagine synthase (glutamine-hydrolysing)

Glycine reversible transport via proton symport

Transport of GlnProGlu, Extracellular

3-Sulfoalanine carboxy-lyase

Transport of TrpIleTrp, Extracellular

Delta4-3-Oxosteroid 5Beta-Reductase

PCHOLN201_HSABCt

Transport of 1-Eicosenoylglycerophosphocholine (Delta 11) , Sn1-Lpc (20:1)

Efflux of cyclosporine-sulphate into bile

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport (ATP-Dependent) into Extracellular Space

Efflux of rosuvastatin-5S-lactone into bile

Sulfate transport, extracellular

Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Cytochrome P450 3A5

Oxaloacetate decarboxylase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Efflux of AM19-cyclosporine into bile

Palmitoyl Coenzyme A Hydrolase

Excretion of Methyl-hydroxy-gliclazide into bile

Transport of GlnHisHis, Extracellular

L-Arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.

Formation of Homocarnosine

Thioesterase/ hydrolase for release of des-isoproylpropionic-acid-fluvastatin in hepatocytes

Steryl-Sulfatase

Stearoyl Coenzyme A Desaturase (N-C18:0CoA -> N-C18:1CoA)

Excretion of 7-beta-OH-gliclazide into bile

Formation of Ursodeoxycholate

Transport of ProAsnCys, Extracellular

L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

PCHOLN225_HSABCt

Transport of 1-Docosapentenoylglycerophosphocholine (Delta 7, 10, 13, 16, 19), Sn1-Lpc (22:5)-W3

Transport of Trptyrtyr, Extracellular

PCHOLN225_HSPLA2

Formation of 1-Docosapentenoylglycerophosphocholine (Delta 7, 10, 13, 16, 19), Sn1-Lpc (22:5)-W3 by Phospholipase A2

L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22

Transport of ArgValTrp, Extracellular

Lysophospholipase

Transport of ArgCysGly, Extracellular

Transport of TrpAlaPro, Extracellular

Transport of AspAsnGlu, Extracellular

Efflux of triol metabolite of pravastatin into bile

3Beta-Hydroxysteroid-4Alpha-Carboxylate 3-Dehydrogenase (Decarboxylating)

Hydrogen peroxide synthesis (NADPH dependent)

Sulphation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes

Transport (ATP-Dependent) into Extracellular Space

Acireductone Synthase (Homo Sapiens)

C 14 sterol reductase

PCHOLN1836_HSABCt

Transport of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 6, 9, 12)

Choline phosphotransferase

Glucuronidated bile acid excretion (LCA-24G)

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Betaine-aldehyde dehydrogenase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Beta-Galactoside Alpha-2, 3-Sialyltransferase

Transport of 15-Tetracosenoate, Diffusion

NAD(P) transhydrogenase

Glycoursodeoxycholic acid 3-sulfate ABC bile acid transporter

Transport of HisLysIle, Extracellular

D-Glucuronolactone:NAD+ oxidoreductase

Adenosine kinase

Folylpolyglutamate synthetase

Bile Acid-CoA:Amino Acid N-Acyltransferase

Phosphatidylinositol 4-kinase

Phosphatidylserine Transport by ABCa1

Transport of Phetyr, Extracellular

Cholic acid sulfotransferase

Formation of Sulfoglycolithocholate

3-Dehydrochenodeoxycholic acid ABC bile acid transporter

Phosphoribosylformylglycinamidine synthase

Very-Long-Chain Enoyl Coenzyme A Reductase

3-Hydroxy-L-tyrosine carboxy-lyase

Transport of ValPheArg, Extracellular

2 hydroxybutyrate cotransport with proton

Dopamine Sulfotransferase

SPHMYLN18114_hs_ATPt

Transport of Sphingomyelin (D18:1/14:0), Active Transport

Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Formation of Hexanoyl-Glycine

Homogentisateoxygen 1 2 oxidoreductase decyclizing

Steryl-Sulfatase

DUTP:uridine 5'-phosphotransferase

Transport of AspLysGlu, Extracellular

4-Nitrophenol Sulfotransferase

Cysteamine oxygenase

Nitrite transport in via proton symport, reversible

Formation of AM1AL-cyclosporine in hepatocytes

Formation of 2-Hydroxy-3-Methyl-Valerate

Transport of 2-Linoleoylglycerophosphoethanolamine

TCDB:2.A.1.13.5 TCDB:2.A.1.13.1

3-methyl-2-oxobutanoate mitochondrial transport via proton symport

Efflux of 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus into bile

Transport of 5, 12, 20-Trihete, Active Transport

Acylphosphatase

Lactosylceramide Alpha-2, 3-Sialyltransferase

ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

Inorganic triphosphatase

Ketohexokinase (D-xylulose)

FMN adenylyltransferase

Glucuronidated bile acid excretion (CA-24G)

Efflux of tacrolimus into intestinal lumen by P-gp

3,4-Dihydroxyphenylethyleneglycol NAD+ oxidoreductase

Transport by Pmat Transporter into Extracellular Space

Conversion of lactone to acid form of atorvastatin in hepatocytes

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

D sorbitol dehydrogenase D fructose producing

Transport of TrpGlyPhe, Extracellular

Transport of Bile Acid, Ursodeoxycholate, Active Transport

Coproporphyrinogen oxidase (O2 required)

Cholesterol efflux (ATP depedent), golgi

Methylsterol Monooxygenase

Transport of AlaLysThr, Extracellular

(N-Acetylneuraminyl)-Galactosylglucosylceramide N-Acetylgalactosaminyltransferase

Efflux of AM1c-glucuronide into bile

17Beta-Estradiol 17-Dehydrogenase

Transport of ProGlnPro, Extracellular

NADPH:Quinone Reductase

PCHOLN183_HSABCt

Transport of 1-Octadeca-Trienoylglycerophosphocholine, Sn1-Lpc (18:3, Delta 9, 12, 15)

Adenosine transport in via proton symport

Retinol dehydrogenase (11-cis,NADH)

5,10-methylenetetrahydrofolate reductase (NADH)

Pantothenate sodium symporter II

3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2

Prostaglandine E1 transport (ATP-dependent)

GABA Secretion via Secretory Vesicle (ATP Driven)

Transport of ProCys, Extracellular

Fatty-acyl-CoA elongation (n-C20:5CoA)

TSTSTERONEGLCte

Glucuronidated compound transport

Dihydrouracil dehydrogenase (NAD)

Chenodeoxycholic acid 6alpha-hydroxylase

Efflux of 6-epipravastatin into bile

Transport of 5(S)-HETE, Active Transport

Dehydrogenation of gliclazide to dehydro-gliclazide in hepatocytes

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Palmitoyl Coenzyme A Hydrolase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Efflux of fluvastatin into bile for excretion into faeces

Formation of 1-Myristoylglycerophosphoethanolamine (C14:0 Pe) by Phospholipase A2

Delta4-3-Oxosteroid 5Beta-Reductase

Efflux of 7-hydroxy-3-alpha-iso-pravastatin into bile

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

Nitric Oxide Synthase (No Forming)

Glycodeoxycholic acid 3-sulfate ABC bile acid transporter

Purine nucleoside phosphorylase

Transport of 5-Amino-4-Oxopentanoate, Proton Symport

Lacaldehyde reductase (S-propane-1,2-diol forming)

Transport of MetHisLys, Extracellular

Dihydropyrimidinase (5,6-dihydrouracil)

Transport of 3Alpha-Hydroxy-5Beta-Androstan-17-One, Endoplasmatic Reticulum

BIOMASS_maintenance_noTrTr

Biomass maintenance reaction without replication, transcription, and translation precursors

Efflux of 4-hydroxy-atorvastatin-lactone into bile

Transport of 1-Myristoylglycerophosphoethanolamine (C14:0 Pe)

Transport of HisLysGlu, Extracellular

6 phosphofructo 2 kinase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Spermine transport via proton antiport irreversible

Efflux of 3-hydroxy-simvastatin-acid form into bile

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Gulonate dehydrogenase

Glycolate dehydrogenase (NADP)

Transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Methylsterol Monooxygenase

Transport of behenoylcoa into peroxisomes

Palmitoyl Coenzyme A Hydrolase

11Beta-Hydroxysteroid Dehydrogenase

PCHOLN19_HSPLA2

Formation of 1-NoNADecanoylglycerophosphocholine, Sn1-Lpc (19:0) by Phospholipase A2

L-glutamate 5-semialdehyde dehydratase (spontaneous)

Lactosylceramide Alpha-2, 3-Sialyltransferase

Efflux of 13,31-O-Didesmethyl-tacrolimus into bile

Stearoyl Coenzyme A 9-Desaturase

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Sphingolipid long chain base kinase sphinganine

Palmitoyl Coenzyme A Hydrolase

Very-Long-Chain Enoyl Coenzyme A Reductase

Palmitoyl Coenzyme A Hydrolase

Transport of 1-Didecanoylglycerophosphoethanolamine (C12:0 Pe)

Glycerophosphocholine Phosphodiesterase

Taurohyocholic acid ABC bile acid transporter

Fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)

Glycine N-Acyltransferase, Phenylacetate

CAMP transport (ATP-dependent)

Ribose transport in via proton symporter

Unspecific Monooxygenase

17Beta-Estradiol 17-Dehydrogenase

Thioredoxin (ubiquinone 10) reductase (NADH)

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Catechol O-Methyltransferase

Phosphatidylinositol N-acetylglucosaminyltransferase

Transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine

Hexokinase (D-mannose:ATP)

S-Adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

(R)-Lactate:Ferricytochrome-C 2-Oxidoreductase

Transport of phytanoylcoa from cytosol to peroxisomes.

Retinol dehydrogenase (13-cis,NADH)

Transport of PheGlnPhe, Extracellular

Glycoursodeoxycholic acid sulfotransferase

Palmitoyl Coenzyme A Hydrolase

Biotin transport via sodium symport

Transport of ProHistyr, Extracellular

Deoxycholic acid sulfotransferase

NADPH:6,7-dihydropteridine oxidoreductase Folate biosynthesis EC:1.5.1.34

4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase

Acireductone dioxygenase

24-Hydroxycholesterol 7Alpha-Hydroxylase

PAILPALM_HSPLA2

Formation of 1-Palmitoylglycerophosphoinositol by Phospholipase A2

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Glucuronidated bile acid excretion (DCA-24g)

Carboxylesterase

Heme oxygenase 1

Prostaglandine E2 transport (ATP-dependent)

Cytochrome P450 2D6

Progesterone, Reduced Ferredoxin:Oxygen Oxidoreductase (11-Hydroxylating)

Mevalonate kinase atp

Transport of ProArgAsp, Extracellular

Vitamin Transport by ABCa4

Isochenodeoxycholic acid ABC bile acid transporter

Glutathione transport into mitochondria

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

NADH:cob(III)alamine oxidoreductase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Transport of Leutyrtyr, Extracellular

Uptake of food iron by DMT1 transporter

Hyocholic acid ABC bile acid transporter

Transport of 12-Hydroperoxyeicosa-5, 8, 10, 14-Tetraenoate, by FATP

Glucuronate transport into lysososme

Folylpolyglutamate synthetase (DHF)

UDPglucuronate uridine-monophosphohydrolase

Transport of SerTrpHis, Extracellular

Transport of 18 Hydroxy Arachidonic Acid, Extracellular Space, Active Transport

Acetate reversible transport via proton symport

Beta-Glucuronidase

Secretion of Noradrenaline via Secretory Vesicle (ATP Driven)

IBUP_SCYPCARhep

Oxidation of S-3-hydroxy ibuprofen to S-carboxy ibuprofen

L alanine reversible transport via proton symport

Phosphopantothenate-cysteine ligase

Spontaneous reaction

Conversion of lactone to open acid form of rosuvastatin

Transport of Allopregnanolone, Extracellular

Folate transport via proton simport

Transport of GluAsnLeu, Extracellular

Phosphofructokinase

Palmitoyl Coenzyme A Hydrolase

Transport of 4-S-Glutathionyl-5, 6-Dihydroxyindoline

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Transport of ThrMetArg, Extracellular

Very-Long-Chain 3-Oxoacyl Coenzyme A Synthase

Transport of TrpHisMet, Extracellular

Very-Long-Chain Enoyl Coenzyme A Reductase

Pantothenate Sodium Symporter Ii

Fatty-acid-CoA thioesterase (hexadecenoate)

Transport of 17Alpha-Hydroxyprogesterone, Extracellular

Transport of Bile Acid, Glycoursodeoxycholate, Active Transport

Palmitoyl Coenzyme A Hydrolase

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Steryl-Sulfatase

Transport of Bile Acid, Sulfochenodeoxycholate, Active Transport

Spermine synthase

Retinyl ester hydrolase (9-cis)

D-Lactaldehyde NAD+ oxidoreductase (glutathione-formylating)

3MOX4HOXPGALDOX_NADP

3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase

SPHMYLN18123_hs_ATPt

Transport of Sphingomyelin (D18:1/23:0), Active

Phosphatidylinositol 4-phosphate phospholipase C

Tauroursodeoxycholic acid 3-sulfate ABC bile acid transporter

Transport of AlaGlyLys, Extracellular

Leukotriene Transport by ABCa8

Norepinephrine Sulfotransferase

Acetone transport via proton symport

Deoxyhypusine Synthase

Palmitoyl Coenzyme A Hydrolase

Palmitoyl Coenzyme A Hydrolase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Palmitoyl Coenzyme A Hydrolase

Transport of Docosahexaenoate

Efflux of AM1c4N9-cyclosporine into bile

12-Dehydrocholic acid ABC bile acid transporter

De-lactonization of cerivastatin-M22 to cerivastatin-M1 in hepatocytes

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Formation of 1-Docosatetraenoyglycerophosphoethanolamine (22:4, Delta 7, 10, 13, 16) by Phospholipase A2

Alpha-Aminobutyryl Histidine Hydrolase

Transport of TrpMetArg, Extracellular

Conjugation of oxypurinol to oxypurinol-7-riboside

Palmitoyl Coenzyme A Hydrolase

Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -> N-C18:2CoA)

Steryl-sulfatase

Transport of 3- (4-Hydroxyphenyl)Lactate

Iduronate transport into lysososme

1-Eicosatrienoylglycerophosphoethanolamine (Delta 11, 14, 17), Lpe (20:3)

Transport of 1-Palmitoylglycerophosphoethanolamine

Transport of AsnMetPro, Extracellular

Transport of Hexadecanediocacid by FATP

Acetoacetate transport via proton symport

Transport of Lipoxin A4, Proton Symport

Efflux of atorvastatin acid by P-gp from the enterocytes into lumen

Transport of AspHisCys, Extracellular

PCHOLN224_HSPLA2

Formation of 1-Docosatetraenoylglycerophosphocholine (Delta 7, 10, 13, 16), Sn1-Lpc (22:4) by Phospholipase A2

Sulphation of acetaminophen in hepatocytes

Iodide:hydrogen-peroxide oxidoreductase

Transport of 8, 9-EET, Active Transport

Pyruvate kinase(4)

Tyraminium Proton Symport, Cytosol

Retinal dehydrogenase (NADPH)

Serine C palmitoyltransferase

Efflux of midazolam by P-gp from the enterocytes into lumen

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Methylsterol Monooxygenase

PCHOL2OLE_HSPLA2

Formation of 2-Oleoylglycerophosphocholine by Phospholipase A2

Aldehyde dehydrogenase (pristanal, NAD)

Conversion of pro-durg lovastatin to active hydroxyacid form in hepatocytes

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

CGMP transport (ATP-dependent)

Transport of TrpThrGlu, Extracellular

PCHOLDOC_HSPLA2

Formation of 1-Docosahexaenoylglycerophosphocholine by Phospholipase A2

Efflux of pitavastatin-M3 into bile

Transport of nervonylcoa into peroxisomes

Efflux of 2-hydroxy-atorvastatin-lactone into bile

Transport of ArgSerSer, Extracellular

Transport of SerArgTrp, Extracellular

N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9

Alpha-N-Acetylneuraminate Alpha-2, 8-Sialyltransferase

GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271

Transport of IleArgIle, Extracellular

S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

Proline dehydrogenase

Excretion of 4-beta-OH-gliclazide into bile

Propinol Adenylate:Coa Ligase (AMP-Forming) Ec:6.2.1.17 Ec:6.2.1.1

Pyruvate transport in via proton symport

Orotic acid transport inout via proton symporter

L-arabinitol 4-dehydrogenase

Na+/K+ Exchanging ATPase

Xylitol dehydrogenase D xyulose forming

5 Aminolevulinate transport in via proton symport

Ketohexokinase (D-tagatose)

L hydroxyproline reductase NADP

L-Tyrosine carboxy-lyase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Transport of 13(S)-HPODE, Active

Transport of TrpLys, Extracellular

Hydroxymethylglutaryl CoA synthase

Transport of LeuProArg, Extracellular

Transport of HisCysCys, Extracellular

Transport of AspGlu, Extracellular

ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.15

Transport of CysCys, Extracellular

PCHOLMYR_HsABCt

Transport of 1-Myristoylglycerophosphocholine

Cytochrome P450 3A4

6,7-dihydropteridine reduction

Estrogen sulfotransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.2

Transport by Pcet into Extracellular Space

Transport of 4- (Trimethylammonio)Butanoate, Proton Symport

Transport of AspProLys, Extracellular

Transport of AspLysHis, Extracellular

Glucuronidated bile acid excretion (LCA-3G)

Transport of W-Hydroxyl Leukotriene B4, Active Transport

Kynurenine 3 monooxygenase

Fatty acyl CoA synthase n C160CoA

PCHOLN205_HSABCt

Transport of 1-Eicosapentenoylglycerophosphocholine (Delta 5, 8, 11, 14, 17), Sn1-Lpc (20:5)

Palmitoyl Coenzyme A Hydrolase

Dopa Transport by Ent4

Transport of PhetyrLys, Extracellular

Steroyl Coenzyme A, Hydrogen-Donor:Oxygen Oxidoreductase Polyunsaturated Fatty Acid Biosynthesis

UDP-glucuronate glucuronohydrolase

Aldehyde dehydrogenase 4 hydroxyphenylacetaldehyde NAD

5Beta-Cholestane-3Alpha, 7Alpha, 12Alpha-Triol, NADPH:Oxygen Oxidoreductase (26-Hydroxylating) Bile Acid Biosynthesis

Pyruvate peroxisomal transport via proton symport

3-dehydro-chenodehydroxycholic acid formation

Transport of TyrAlaPhe, Extracellular

Transport of 12 (13)-Epome, FATP

Quinine 3-Monooxygenase

Sphingosine N-Acyltransferase

Metabolism (Formation/Degradation) of TrpProGly

Efflux of 3-OH-acetaminophen into hepatic vein

Palmitoyl Coenzyme A Hydrolase

Transport of 5-S-Glutathionyl-L-Dopa

Transport of GlyHisLys, Extracellular

Transport of 5Beta-Cholestane-3Alpha, 7Alpha, 26-Triol, Active Transport

Dopamine 4-O-Glucuronidation

N Formyl L kynurenine amidohydrolase

SPHMYLN1825_hs_ATPt

Transport of Sphingomyelin (D18:0/25:0), Active Transport

Palmitoyl Coenzyme A Hydrolase

3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

2HATVLACGLUCteb

Efflux of 2-hydroxy-atorvastatin-lactone-glucuronide into bile

Acetyl-CoA hydrolase

PCHOLN203_HSABCt

Transport of 1-Dihomo-Linolenoylglycerophosphocholine (20:3, Delta 8, 11, 14), Lysopc A C20:3

Efflux of rosuvastatin by BCRP from the enterocytes into lumen

Butyrate transport via proton symport, reversible

Transport of PheLeuHis, Extracellular

Beta-Galactoside Alpha-2, 3-Sialyltransferase

FACOAE1836Z9Z12Z

Gamma-Linolenoyl-CoA hydrolase (18:3(6Z,9Z,12Z))

Carnitine O-Palmitoyltransferase

Transport of SerArgAla, Extracellular

D lactate transport mitochondrial

Bile Acid-CoA:Amino Acid N-Acyltransferase

Conversion of simvastatin pro-drug to active form

S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284

Efflux of lovastatin lactone by P-gp from the enterocytes into lumen

Formation of 9 (10)-Epome

DUTP diphosphatase

Dolichol kinase, human (uterus)

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Transport of 15(S)-HPETE, Active Transport

PCHOL2LINL_HSPLA2

Formation of 2-Linoleoylglycerophosphocholine by Phospholipase A2

(N-Acetylneuraminyl)-Galactosylglucosylceramide N-Acetylgalactosaminyltransferase

Transport of SerLysHis, Extracellular

Cytochrome P450 2C9

Delta4-3-Oxosteroid 5Beta-Reductase

Transport of 5, 8, 11, 14, 17-Eicosapentenoic Acid, Mitochondrial

Steroid sulfotransferase

Phosphatidylinositol-5-phosphate 3-kinase

CTP synthase NH3

5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase

Retinol dehydrogenase (all-trans,NADPH)

Catechol O-Methyltransferase

Aspartate 1-decarboxylase

Transport of IleProLys, Extracellular

17Alpha-Hydroxypregnenolone Acetaldehyde-Lyase

Formation of Tyraminium

Transport of 7, 10, 13-Hexadecatrienoic Acid into Extracellular Space

Efflux of 13-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

Prostaglandin G/H synthase

PCHOLN15_HSPLA2

Formation of 1-Pentadecanoylglycerophosphocholine, Sn1-Lpc (15:0) by Phospholipase A2

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Ganglioside Galactosyltransferase

DATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40

Glycochenodeoxycholic acid 3-sulfate ABC bile acid transporter

Glycolaldehyde dehydrogenase

D-aspartate transport via Na, H symport and K antiport

Linoleoyl-CoA hydrolase (18:2(9Z,12Z))

Putrescine acetyltransferase

Very-Long-Chain 3-Oxoacyl Coenzyme A Reductase

Cholesterol 25-Hydroxylase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport

Transport by ABCg2 into Extracellular Space

Glycolysis / Glyconeogenesis EC:2.7.1.1

Dopamine Beta-Monooxygenase

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

Excretion of 7-alpha-OH-gliclazide into bile

Pantetheine-phosphate adenylyltransferase

SPHMYLN18121_hs_ATPt

Transport of Sphingomyelin (D18:1/21:0), Active

Demethylation of AM1A to AM1A4N in hepatocytes

Transport of GluLeu, Extracellular

Presqualene-Diphosphate Diphosphate-Lyase (Reducing, Squalene-Forming)

Transport of ProLysPro, Extracellular

Transport of 11, 12-EET, FATP

Myo-Inositol:oxygen oxidoreductase

Very-Long-Chain Enoyl Coenzyme A Reductase

Glycerol-3-phosphate dehydrogenase (NADP)

Transport of LeuPro, Extracellular

HCO3 equilibration reaction

Guanine deaminase

Arabinose reductase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

PCHOLN264_HSABCt

Transport of 1-Lignocericylglycerophosphocholine (24:0), Lysopc A C24

Dhea Transport by ABCa11

Transport of ProTrpThr, Extracellular

Fatty-acid-CoA thioesterase (octadecenoate)

Formation of 1-Palmitoylglycerophosphoethanolamine by Phospholipase A2

1-Alkyl 2-Acylglycerol 3-Phosphocholine Transport

Folylpolyglutamate Synthetase

L-Tyrosine:Oxygen Oxidoreductase

Palmitoyl Coenzyme A Hydrolase

Very-Long-Chain Enoyl Coenzyme A Reductase

Mitochondrial Carrier (Mc) Tcdb:2.A.29.19.1

Unspecific Monooxygenase

Efflux of 15-O-desmethyl tacrolimus into intestinal lumen by ABC transporter

S-Formylglutathione hydralase

Release of oxypurinol into portal blood

Aspartate carbamoyltransferase

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Universal metabolite ?

h

External database links

InChI Key: GPRLSGONYQIRFK-UHFFFAOYSA-N
Reactome Compound: 1132304, 113529, 1470067, 156540, 163953, 193465, 194688, 2000349, 2872447, 351626, 372511, 374900, 425969, 425978, 425999, 427899, 428040, 428548, 5668577, 70106, 74722
SEED Compound: cpd00067
CHEBI: CHEBI:10744, CHEBI:13357, CHEBI:15378, CHEBI:5584
Human Metabolome Database: HMDB59597
MetaNetX (MNX) Chemical: MNXM1
KEGG Compound: C00080
BioCyc: META:PROTON

Provided by MetaNetX (CC BY 4.0)

Old identifiers

h[c]

h in other models