Reaction: LSTNM7hr

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Descriptive name:

Glucuronidation of losartan to losartan-M7/Losartan-N2-glucuronide in hepatocytes

Model:

Recon3D

Reaction:

udpglcur_r + lstn_r → udp_r + lstnm7_r

Metabolites:

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Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

54658_AT1 or 54659_AT1 or 54657_AT1 or 54577_AT1 or 54576_AT1 or 54600_AT1 or 54575_AT1 or 7364_AT1 or 7367_AT1

Genes:

54576_AT1 (UGT1A8)
54575_AT1 (UGT1A10)
54657_AT1 (UGT1A4)
54658_AT1 (UGT1A1)
54659_AT1 (UGT1A3)
54577_AT1 (UGT1A7)
54600_AT1 (UGT1A9)
7364_AT1 (UGT2B7)
7367_AT1 (UGT2B17)

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