Reaction: ATVACYLGLUChc

Descriptive name:

Glucuronidation of atorvastatin to atorvastatin acyl glucuronide (G2) in hepatocytes

Model:

Recon3D

Reaction:

udpglcur_r + atvacid_r → udp_r + atvacylgluc_r

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
udp_r
UDP C9H11N2O12P2
-1.0
udpglcur_r
UDP-D-glucuronate
-1.0
atvacid_r
Atorvastatin-acid
1.0
atvacylgluc_r
Atorvastatin-acyl-glucuronide / G2

Default bounds:

(0.0, 1000.0)

Objective coefficient:

0.0

Subsystem:

Drug metabolism

Gene Reaction Rule:

54659_AT1 or 54657_AT1 or 54658_AT1 or 54576_AT1 or 7364_AT1

Genes:

54657_AT1 (UGT1A4)
54658_AT1 (UGT1A1)
54659_AT1 (UGT1A3)
7364_AT1 (UGT2B7)
54576_AT1 (UGT1A8)

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Universal reaction ?

External database links

Old identifiers

    ATVACYLGLUChc

ATVACYLGLUChc in other models