BiGG Models

Gene: 1244_AT1

Descriptive name:

ABCC2

Model:

Position:

Left: 99782845 – Right: 99851631

Strand:

Plus

Chromosome:

Associated reactions:

BiGG ID

Name

Gene reaction rule

Bilirubin beta-diglucuronide transport MDR

4363_AT1 or 1244_AT1 or 8714_AT1

ATP-binding Cassette (ABC) TCDB:3.A.1.208.2

Folate Transport by ABCa11

85320_AT1 or 4363_AT1 or 1244_AT1 or 5244_AT1 or 10257_AT1 or 10057_AT1 or 9429_AT1

Transport of Bile Acid, Ursodeoxycholate, Active Transport

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Transport of Bile Acid, Sulfochenodeoxycholate, Active Transport

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

Transport by Atb Binding Cassette Transporter ABCc2 into Extracellular Space

1244_AT1 or 10058_AT1

Transport by ABCa11 into Extracellular Space

85320_AT1 or 4363_AT1 or 1244_AT1 or 5244_AT1 or 10257_AT1 or 10057_AT1 or 9429_AT1

1244_AT1 or 4363_AT1

12-Dehydrocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

3-Dehydrochenodeoxycholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

3-Dehydrocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

3-dehydro-deoxycholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1

3-dehydro-lithocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1

7-Dehydrochenodeoxycholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

7-Dehydrocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Glucuronidated bile acid excretion (CA-24G)

8714_AT3 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Cholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (CDCA-24G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (CDCA-3G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Coprostanol ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Glucuronidated bile acid excretion (DCA-24g)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (DCA-3G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Deoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glycocholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glycochenodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glycodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glycoursodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (HCA-24G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (HCA-6G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (HDCA-24G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (HDCA-6G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Hyocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1

Isochenodeoxycholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Isocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Glucuronidated bile acid excretion (LCA-24G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Glucuronidated bile acid excretion (LCA-3G)

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 9429_AT1

Lithocholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Taurocholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Taurochenodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Taurodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Taurohyocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1

Tauroursodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

Ursocholic acid ABC bile acid transporter

8714_AT3 or 8647_AT1 or 8714_AT2 or 8714_AT1 or 1244_AT1 or 10257_AT1

Ursodeoxycholic acid 3-sulfate ABC bile acid transporter

8714_AT3 or 8714_AT2 or 8714_AT1 or 10257_AT1 or 1244_AT1 or 9429_AT1

2HATVACIDGLUCteb

Efflux of 2-hydroxy-atorvastatin-acyl-glucuronide into bile

1244_AT1 or 5243_AT1

Efflux of 2-hydroxy-atorvastatin-acid into bile

1244_AT1 or 5243_AT1

2HATVLACGLUCteb

Efflux of 2-hydroxy-atorvastatin-lactone-glucuronide into bile

1244_AT1 or 5243_AT1

Efflux of 2-hydroxy-atorvastatin-lactone into bile

1244_AT1 or 5243_AT1

Efflux of 3-S-hydroxy-pravastatin-tetranor into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 3-S-hydroxy-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 3-alpha-iso-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 4-hydroxy-atorvastatin-acid into bile

1244_AT1 or 5243_AT1

Efflux of 4-hydroxy-atorvastatin-lactone into bile

1244_AT1 or 5243_AT1

Efflux of 3-keto-5,6,-dihydroxy-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 5,6-epoxy-3-alpha-iso-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 6-epipravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of 7-hydroxy-3-alpha-iso-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of desacyl dehydro-pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Pravastatin efflux into lumen for excretion into feces

1244_AT1 or 9429_AT1

Efflux of pravastatin glucuronide into bile

1244_AT1 or 9429_AT1 or 8647_AT1

Efflux of triol metabolite of pravastatin into bile

1244_AT1 or 9429_AT1 or 8647_AT1

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External database links

Online Mendelian Inheritance in Man: 601107
Human Protein Reference Database: 03065
NCBI Entrez Gene: 1244
CCDS: CCDS7484.1

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Old identifiers

1244.1