Nov. 23, 2016
Version 1.3 introduces a new model and includes a number of bug fixes.
To understand the pathways underlying cell growth and protein production in Chinese hamster ovary (CHO) cells, the production cell line for most recombinant protein drugs, Hefzi et al. develop a genome-scale model of all metabolic pathways and use this to analyze the efficacy of common cell treatments used to boost protein production. The model builds off the human genome-scale models RECON1 and RECON2, and has been extensively curated to ensure a high-quality resource for use in studying this model organism. The new model is in BiGG Models with the name iCHOv1.Github Release