L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
o2_c + phe__L_c + thbpt_c ⇌ h2o_c + tyr__L_c + dhbpt_c
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