BiGG Models

Metabolite: h_c

Descriptive name:

H+

Model:

Formula:

H

Charge:

1

Compartment:

Reactions:

BiGG ID

Name

FAD diphosphatase

Efflux of alpha-Tocopherol into the lyphatics in chylomicrons

Deoxyuridine kinase (ATP:Deoxyuridine)

Pyruvate mitochondrial transport via proton symport

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Uptake of food iron by DMT1 transporter

(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

N-acetylgalactosamine kinase

Glycolipid 1,6-alpha-D-mannosyltransferase (CHO)

Transport of Stearoyl-CoA from cytosol to peroxisomes

Aspartate-glutamate mitochondrial shuttle

3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

Fatty acid omega-hydroxylase

D lactate transport via proton symport

Cytochrome P450 2C18

Fatty acyl ACP hydrolase

3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase

Uroporphyrinogen decarboxylase (uroporphyrinogen III)

Aldehyde Reductase

L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22

Phosphatidylinositol 4-kinase

Lipoate transport via sodium symport

Choline-phosphate cytidylyltransferase

Adenylyl-sulfate kinase

Catechol O-Methyltransferase

Guanosine aminohydrolase EC:3.5.4.15

Transport of stearidonylcoa into peroxisomes.

Nucleoside triphosphate pyrophosphorylase (dttp)

Amino acid transporter (glu-L), mitochondrial

Transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine

Glucose 6-phosphate dehydrogenase

Fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

Propinol adenylate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.17 EC:6.2.1.1

Steroid 21-Monooxygenase

Aldehyde Dehydrogenase (NAD+)

Xylose reductase

Dihydrofolate reductase (NAD+)

3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

Transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.

S-Adenosyl-L-methionine:amine N-methyltransferase (srtn)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Formyl coa hydrolase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Gamma-glutamylcysteine synthetase

Aldehyde dehydrogenase (phenylacetaldehyde, NAD)

Adrenaline secretion via secretory vesicle (ATP driven)

GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16

Phosphatidylinositol 4,5-bisphosphate phospholipase C

Pyruvate transport in via proton symport

Potassium transport out via proton antiport

Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

Nucleoside triphosphate pyrophosphorylase (ditp)

D-Glucuronolactone:NAD+ oxidoreductase

Norepinephrine Sulfotransferase

Cytochrome P450 2D6

Nucleoside diphosphatase UDP

Hyaluronan synthase

Betaine-aldehyde dehydrogenase

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Cardiolipin synthase (cho)

Riboflavin transport (ATP dependent)

Iduronate transport into lysososme

Alcohol dehydrogenase (D-lactaldehyde)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Fatty acid omega-hydroxylase

Pyrroline-5-carboxylate reductase

Hypoxanthine dehydrogenase

S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

Xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

Thiamine transport in via proton symport, mitochondrial

L serine reversible transport via proton symport

(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport

UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.55.2.3

ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

Glycerol kinase

Asparagine synthase (glutamine-hydrolysing)

3-Hydroxykynurenamine decarboxy-lyase

Ceramide glucosyltransferase

34DHPLACOX_NADP

34DHPLACOX LPAREN NADP RPAREN

Transport of nervonylcoa into peroxisomes

Phosphatidylserine flippase

3-Methyl-2-oxopentanoate mitochondrial transport via proton symport

L lactate transport mitochondrial

2,3-dioxo-L-gulonate:hydrogen peroxide oxireductase

Butyrate transport via proton symport, reversible

Alcohol dehydrogenase (methanol)

Aminobutyraldehyde dehydrogenase

Thiamin pyrophosphatase

Retinol dehydrogenase (9-cis,NADH)

Folylpolyglutamate synthetase

Cholesterol efflux (ATP depedent)

Gulonate dehydrogenase

N Formyl L kynurenine amidohydrolase

Transport of behenoylcoa into peroxisomes

NADH:cob(III)alamine oxidoreductase

Glycerol 3 phosphate dehydrogenase NAD

Formimidoyltransferase cyclodeaminase reversible

Aminomuconate-semialdehyde dehydrogenase

Porphobilinogen synthase

ABC bile acid transporter

Hexadecanal:NADP+ delta2-oxidoreductase EC:1.3.1.27

5ADTSTSTERONESULT

5alpha-Dihydrotestosterone sulfotransferase

Pyridoxamine kinase

Aldehyde dehydrogenase (acetaldehyde, NADP)

Carbonyl Reductase (NADPH)

GDP-L-fucose synthase

Pyridoxine kinase

Nad(p)h biliverdin reductase

Hydroxypyruvate decarboxylase

Acetate mitochondrial transport via proton symport

Cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

Hyaluronan synthase

2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

3,4-Dihydroxyphenylacetate:amet O-methyltransferase

4'-Phosphopantothenate:L-cysteine ligase

Myo-Inositol:oxygen oxidoreductase

Phosphoribosylaminoimidazolesuccinocarboxamide synthase

Phosphatidylinositol N-acetylglucosaminyltransferase

Retinyl ester hydrolase (9-cis)

D-xylose:NADP+ 1-oxidoreductase

Cytosine deaminase

Citrate reversible transport via symport

TCDB:2.A.1.13.5 TCDB:2.A.1.13.1

Thioredoxin reductase (NADPH)

Carbamoyl-phosphate synthase (glutamine-hydrolysing)

Thioredoxin (ubiquinone 10) reductase (NADH)

Cytochrome P450 3A4

Alcohol dehydrogenase glycerol NADP

Folylpolyglutamate synthetase (10fthf)

Thymidine Kinase

Polyphosphate phosphohydrolase

NAD nucleosidase

DUTP diphosphatase

Cytochrome P450 2C9

Transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Folylpolyglutamate synthetase (10fthf)

3MOX4HOXPGALDOX

3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase

Hydrogen peroxide synthesis (NADPH dependent)

Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.

Sepiapterin reductase

D-aspartate transport via Na, H symport and K antiport

3-mercaptopyruvate sulfurtransferase

Phosphoethanolamine cytidyltransferase

Acetone monooxygenase

N-acetylglucosamine kinase

Glycerate kinase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Phosphatidylinositol 4-phosphate phospholipase C

Phosphatidylinositol synthase (Homo sapiens)

Nucleoside-diphosphatase (dUDP)

Sphingosine kinase

Glucuronate transport into lysososme

Phosphopantothenoylcysteine decarboxylase

Catechol O-Methyltransferase

L-sulfolactate dehydrogenase (NAD+)

Dehydrodolichol reductase (CHO)

CGMP transport (ATP-dependent)

D lactate transport mitochondrial

Unspecific Monooxygenase

Palmitoyl Coenzyme A Hydrolase

Glycine secretion via secretory vesicle (ATP driven)

Phospholipase A2

Deoxycytidine deaminase

Choline phosphotransferase

Dihydropyrimidinase (dihydrothymine)

UDP-glucose glucophosphohydrolase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

NADP nucleosidase

L-aspartate transport via Na, H symport and K antiport

Proton transport, Golgi

Hexokinase (D-glucosamine:ATP)

Glycine reversible transport via proton symport (lysosome)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

5-Hydroxy-L-tryptophan decarboxy-lyase

L-Tyrosine carboxy-lyase

UTP-glucose-1-phosphate uridylyltransferase (irreversible)

D-Lactaldehyde NAD+ oxidoreductase (glutathione-formylating)

Ap4A hydrolase, asymmetrically

D-Lactaldehyde:NAD+ 1-oxidoreductase

5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

N1-Methylnicotinamide transport

Beta-D-Glucosyl-2-coumarinate glucohydrolase

Glutamine transport (Na, H coupled)

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

L lactate reversible transport via proton symport

Fatty-acyl-ACP hydrolase

Nucleoside triphosphate pyrophosphorylase (xtp)

CMP-N-acetylneuraminate monooxygenase, NADH

Fatty-acyl-CoA elongation (n-C20:5CoA)

Steryl-Sulfatase

Diphosphoglyceromutase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Spermidine synthase

Glycine N-methyltransferase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Acetyl-CoA hydrolase

Lactaldehyde dehydrogenase

H transporter, endoplasmic reticulum

Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16

Deoxycytidine kinase

2-aminomuconate reductase

Methenyltetrahydrofolate cyclohydrolase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Fatty-acid biosynthesis (n-C12:0ACP)

Riboflavin kinase

3',5'-cyclic-nucleotide phosphodiesterase

3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2

2-methylcitrate synthase

Alcohol Dehydrogenase

Glyceraldehyde-3-phosphate dehydrogenase

Phosphatidylinositol-5-phosphate 3-kinase

Nucleoside diphosphatase GDP

Glutathione synthetase

Nadh biliverdin reductase

D-Galactose:NADP+ 1-oxidoreductase

Nicotinate-mononucleotide adenylyltransferase

Argininosuccinate synthase

Catechol O-Methyltransferase

GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271

Carnosine synthase

Biotin acetyl CoA carboxylase ligase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Beta-ureidopropionase (D-3-amino-isobutanoate forming)

Histidine transport (Na, H coupled)

Ceramide kinase

Cytidine kinase (GTP)

Fatty-acyl-CoA elongation (n-C20:4CoA)

Serine transport (Na, H coupled)

Xylitol dehydrogenase D xyulose forming

Hydroxypyruvate reductase (NADH)

4-aminobutyrate reversible transport in via proton symport (lysosome)

Hydroxyacylglutathione hydrolase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Steroid sulfotransferase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Biotin transport via sodium symport

Dihydrosphingosine N-acyltransferase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Inositol-tetrakisphosphate 1-kinase

Lactosylceramide 4-alpha-galactosyltransferase

34DHXMANDACOX_NADP

3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

Glutamine synthetase

Fucose-1-phosphate guanylyltransferase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Cytochrome P450 2F1

Quinine 3-Monooxygenase

6-phosphogluconolactonase

3-Mercaptolactate:NAD+ oxidoreductase irreversible

Inositol transport in via proton symport

R group coenzyme a ligase

2 hydroxybutyrate cotransport with proton

AHANDROSTANGLCte

Glucuronidated compound transport

4 aminobutyrate reversible transport in via proton symport

Proline oxidase L proline NAD

Carbonyl Reductase (NADPH)

Inositol-3,4,5,6-tetrakisphosphate 1-kinase

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Quinolinate Synthase Eukaryotic

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Cytochrome P450 2C9

Leukotriene-B4 20-Monooxygenase

H transporter, peroxisome

Aldehyde dehydrogenase (pristanal, NAD)

Phosphatidate cytidylyltransferase

Thiamine-triphosphatase

Ethanolamine phosphotransferase

6,7-dihydropteridine reductase

L hydroxyproline reductase NADP

Hydroxypyruvate reductase (NADH)

Histidine decarboxylase

CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

Alkyl glycerol phosphate acyltransferase

5 10 methylenetetrahydrofolatereductase NADPH

L-alanine reversible transport via proton symport (lysosome)

Cytochrome P450 2C19

6-Lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2-oxidoreductase Folate biosynthesis EC:1.1.1.220

Folylpolyglutamate synthetase

S-Adenosyl-L-methionine:catechol O-methyltransferase

Hexokinase (D-glucose:ATP)

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Phosphoribosylpyrophosphate synthetase

Aromatic-L-Amino-Acid Decarboxylase

Phosphoribosylaminoimidazole carboxylase

N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

5 diphosphoinositol 1 2 3 4 6 pentakisphosphate diphosphohydrolase

L-gulonate 3-dehydrogenase

Biomass function

Dihydroceramide desaturase

Nucleoside-diphosphatase (dCDP)

ABC transporter

Retinal dehydrogenase

Aldose reductase (methylglyoxal)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16

Retinyl ester hydrolase (11-cis)

2-keto-4-methylthiobutyrate transamination

UDPglucose 6-dehydrogenase

TCDB:2.A.1.13.5 TCDB:2.A.1.13.1

Nucleoside diphosphatase ADP

Acetyl-CoA:aralkylamine N-acetyltransferase

Cholesterol efflux (ATP depedent), golgi

Fatty acyl ACP hydrolase

Catechol O-Methyltransferase

ADPmannose diphosphatase

Phosphatidylinositol 3-phosphate 5-kinase

HCO3 equilibration reaction

3-sulfino-alanine transaminase (irreversible)

ADPribose diphosphatase

Serine C palmitoyltransferase

Phosphatidylethanolamine flippase

ABC bile acid transporter

Alkyl acylglycerol phosphoethanolamine transferase

4-methyl-2-oxopentanoate mitochondrial transport via proton symport

ATP-binding Cassette (ABC) TCDB:3.A.1.208.2

D-glucose transport in via proton symport

Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

Acetylcholine secretion via secretory vesicle (ATP driven)

Pyruvate kinase

Aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

Phosphatidyl-CMP: glycerophosphate phosphatidyltransferase

Inorganic triphosphatase

Thyroid peroxidase

Thioredoxin (ubiquinone 10) reductase (NADPH)

Fatty-acyl-ACP hydrolase

Kynurenine 3 monooxygenase

ADPglucose diphosphatase

NAD(P) transhydrogenase

Carbonyl reductase [NADPH] 1

Guanine deaminase

Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17

Iodide:hydrogen-peroxide oxidoreductase

Aldehyde dehydrogenase 4 hydroxyphenylacetaldehyde NAD

Acylphosphatase

N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9

CAMP transport (ATP-dependent)

Selenocysteine lyase

2 3 cyclic nucleotide 2 phosphodiesterase 2 3 cyclic UMP

DUTP:cytidine 5'-phosphotransferase

Transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Formaldehyde dehydrogenase

Perillyl aldehyde:NAD+ oxidoreductase

Acetone transport via proton symport

UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase

Adenosine kinase

Alkyl glycerol phosphate reductase

Retinol dehydrogenase (11-cis,NADPH)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

TSTSTERONEGLCte

Glucuronidated compound transport

Pyruvate peroxisomal transport via proton symport

Sphingomyelin phosphodiesterase

Ethanolamine-phosphate cytidylyltransferase

N-acetyl-D-mannosamine kinase

Dimethylarginine Dimethylaminohydrolase

Fatty-acid-CoA thioesterase (octadecanoate)

Dopaquinone isomerase 1

Cytochrome P450 2A6

Dihydrofolate reductase

N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

Transport of taurine into the intestinal cells by PAT1

2,3-dioxo-L-gulonate:hydrogen peroxide oxireductase

Phosphoribosylglycinamide synthase

Phosphatidylinositol 4-phosphate 3-kinase

NAD diphosphatase

Coproporphyrinogen oxidase (O2 required)

3,4-Dihydroxyphenylethyleneglycol NAD+ oxidoreductase

Thiamine exit from the neterocytes

Imidazolonepropionase

B-alanine secretion via secretory vesicle (ATP driven)

Phosphatidylinositol 3,4-bisphosphate 5-kinase

Carbonyl Reductase (NADPH)

L-proline reversible transport via proton symport (lysosome)

Transport of pristanoylcoa from cytosol to peroxisomes.

Dihydrouracil dehydrogenase (NAD)

Folylpolyglutamate synthetase (10fthf)

S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284

2 HydroxybutyrateNAD oxidoreductase

Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)

Glutamate transport via Na, H symport and K antiport

Melatonin:NADP oxidoreductase

Bicarbonate transport (HCl/NaHCO3 exchange)

Deoxyhypusine Synthase

Transport of Glycylproline by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

UDP-N-acetylglucosamine diphosphorylase

Aldehyde dehydrogenase (phenylacetaldehyde, NADP)

Aldehyde dehydrogenase (acetaldehyde, NAD)

L proline reversible transport via proton symport

Dolichol kinase

L-Histidine:4-aminobutanoate ligase (AMP-forming) Urea cycle and metabolism of amino groups EC:6.3.2.11

Glycolipid 1,2-alpha-D-mannosyltransferase

5ADTSTSTERONEGLCte

Glucuronidated compound transport

Purine nucleoside phosphorylase

Choline phosphatase

Hexokinase (D-fructose:ATP)

Sulfite oxidase

Fatty acid biosynthesis (n-C8:0ACP), lumped reaction

Lacaldehyde reductase (R-propane-1,2-diol forming)

Cysteine oxidase

Sulfate adenylyltransferase

Sphingomyelinase

3-methyl-2-oxobutanoate mitochondrial transport via proton symport

4-Pyridoxal secretion

Superoxide dismutase

Folylpolyglutamate synthetase (DHF)

Selenate adenylyltransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Xylulose reductase

Adenosylmethionine decarboxylase

Trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

Mevalonate kinase atp

Phosphatidylinositol 3-phosphate 4-kinase

Pyruvate kinase(3)

Hydroxymethylglutaryl CoA synthase

Alcohol dehydrogenase (ethanol)

Glycolaldehyde dehydrogenase

Ketohexokinase (D-xylulose)

Transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Xanthine dehydrogenase

Nucleoside triphosphate pyrophosphorylase (itp)

Tyramine Sulfotransferase

Inosine diphosphate phosphatase

Fatty acid omega-hydroxylase

Transport of lignocericyl coenzyme A from cytosol to peroxisome.

CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

L-aminoadipate-semialdehyde dehydrogenase (NADH)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Steryl-sulfatase

Active transport

D-lactate dehydrogenase

3MOX4HOXPGALDOX_NADP

3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase

Phylloquinone transport

D-ribulokinase (D-ribulose)

Imidazole acetaldeyde dehydrogenase

Hydroxylysine kinase

Alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

epo_translation

Epo translation

L-Phenylalanine carboxy-lyase

3Alpha-Hydroxysteroid 3-Dehydrogenase (Si-Specific)

Dehydroascorbate reductase

Vitamin D3 25-hydroxylase

ABC bile acid transporter

5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)

Leukotriene-B4 20-Monooxygenase

Acetone mitochondrial transport via proton symport

Spermidine acetyltransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

L alanine reversible transport via proton symport

Glutathione-disulfide reductase

L-arabinitol 4-dehydrogenase

Leukotriene-B4 20-Monooxygenase

Steryl-Sulfatase

3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase

Thiamine transport in via proton antiport

Beta Alanine transport in via proton symport

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56

Dephospho-CoA kinase

ATP:pantetheine 4'-phosphotransferase

Carbonyl Reductase (NADPH)

Dihydrothymin dehydrogenase (NADP)

Transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Alkyl acyl glycerophosphoethanolamine desaturase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Cysteinesulfinic acid oxidase

Ketohexokinase (D-tagatose)

GABA secretion via secretory vesicle (ATP driven)

Fatty-acyl-CoA elongation (n-C20:4CoA)

Phosphatidylinositol phospholipase C

Glycine hydroxymethyltransferase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.8

Glycolipid 1,3-alpha-D-mannosyltransferase (CHO)

Inositol-1,4,5-trisphosphate 3-kinase

Dopamine:amet O-methyltransferase

Transport of L-Histidine by hPT3 or hPT4 peptide transporters.

Phosphatidylinositol 3-kinase

Dopamine secretion via secretory vesicle (ATP driven)

Cysteamine oxygenase

Adenosine kinase

Dihydrouracil dehydrogenase (NADP)

Dehydroepiandrosterone sulfotransferase

ADP-dependent glucokinase

Arachidonate 5-Lipoxygenase

Glucuronolactone reductase

3 hydroxyanthranilate 3 4 dioxygenase

Retinol dehydrogenase (11-cis,NADH)

Deoxyadenosine deaminase

Carbonyl Reductase (NADPH)

5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase

Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

5-hydroxyisourate amidohydrolase

L-Arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Ascorbic acid oxidase

D-lactaldehyde dehydrogenase

Aspartate 1-decarboxylase

N-acetylneuraminate transport into lysososme

Deamino-NAD+ nucleotidohydrolase

Orotidine-5'-phosphate decarboxylase

Pantothenate kinase

3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

Aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

N4 AcetylaminobutanalNAD oxidoreductase

Fatty acid biosynthesis (n-C10:0ACP)

Phosphoadenylyl-sulfate reductase (thioredoxin)

Noradrenaline N-methyltransferase

3-Hydroxy-L-tyrosine carboxy-lyase

UDP-N-acetylgalactosamine diphosphorylase

Glucuronidated compound transport

Adenylyl-selenate kinase

Cytochrome P450 3A5

Aspartate carbamoyltransferase

5,10-methylenetetrahydrofolate reductase (NADH)

Platelet-activating factor acetylhydrolase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Tetrahydrobiopterin:NADP+ oxidoreductase Folate biosynthesis EC:1.1.1.153

Prostaglandine E2 transport (ATP-dependent)

Fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)

Bilirubin monoglucuronide transport MDR

V-type ATPase, H+ transporting, lysosomal

NADPH:6,7-dihydropteridine oxidoreductase Folate biosynthesis EC:1.5.1.34

ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

Retinal dehydrogenase

5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven)

Dehydrodolichol diphosphate phosphatase (CHO)

UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

Glutathione oxidoreductase

Fatty-acyl-ACP hydrolase

Spontaneous reaction

5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Phosphoribosylformylglycinamidine synthase

Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

D-alanine transport via proton symport (lysosome)

Betaine-aldehyde dehydrogenase

Cytidine deaminase

3-Sulfino-L-alanine carboxy-lyase

Ethanol monooxygenase

S-Adenosyl-L-methionine:catechol O-methyltransferase

Holocarboxylase synthestase (biotin protein ligase)

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Oxaloacetate decarboxylase

UDPglucuronate uridine-monophosphohydrolase

Diphosphoinositol 1 3 4 6 tetrakisphosphate diphosphohydrolase

Formation of sulfocysteine

3-mercaptolactate:cysteine reductase

ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase

D-proline reversible transport via proton symport (lysosome)

Ribosylnicotinamide kinase

Potassium transport via proton antiport

L-Formylkynurenine hydrolase

Inositol-1,3,4,5,6-pentakisphosphate 2-kinase

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Propane-1,2-diol:NADP+ 1-oxidoreductase

Spermine synthase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine

Acetoacetate transport via proton symport

Apocarboxylase formation

Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

Transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.

Phosphate transporter mitochondrial

Aldehyde dehydrogenase (indole-3-acetaldehyde, NAD)

Hydroxypyruvate reductase (NADPH)

Nicotinate-nucleotide diphosphorylase (carboxylating)

Lysophospholipase

NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9

Retinol dehydrogenase (9-cis,NADPH)

Choline phosphate cytididyltransferase

Glucose-1,6-bisphosphate synthase

Pantothenate sodium symporter II

ATP maintenance requirement

ATP:cytidine 5'-phosphotransferase

Fatty-acyl-ACP hydrolase

Phosphopantothenate-cysteine ligase

Unspecific Monooxygenase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Glycerate kinase

D-glucose transport in via proton symport

Alkyl acylglycerol phosphocholine transferase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

CMP-N-acetylneuraminate monooxygenase, NADPH

Bile Acid-CoA:Amino Acid N-Acyltransferase

Retinoic acid hydroxylation (P450)

Folylpolyglutamate synthetase (DHF)

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

3-Methylimidazole acetaldehyde:NAD+ oxidoreductase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

17Beta-Estradiol 17-Dehydrogenase

D sorbitol reductase

Glutamate Decarboxylase

Adenosine monophosphate deaminase

Biotin reversible transport via proton symport, mitochondria

Transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Histidine mitochondrial transport via proton symport

Nucleoside triphosphate pyrophosphorylase (datp)

Fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)

Thiamine diphosphokinase

Phosphatidylcholine transporter

Cytochrome P450 2C9

Prostaglandine E1 transport (ATP-dependent)

Histamine secretion via secretory vesicle (ATP driven)

L-glutamate secretion via secretory vesicle (ATP driven)

Pyruvate kinase(4)

Phosphatidylinositol-5-phosphate 4-kinase

4-Nitrophenol Sulfotransferase

Transport reaction

Trans-2-enoyl-CoA reductase (18:0) (NADPH)

Sodium proton antiporter HNA is 11

3 Dehydrosphinganine reductase

Prostaglandin G/H synthase

Metanephrine secretion via secretory vesicle (ATP driven)

Glycolate dehydrogenase (NADP)

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

Beta-Aminopropion aldehyde NAD+ oxidoreductase

L-carnitine outward transport (H+ antiport)

Uridine kinase ATPUridine

6,7-dihydropteridine reduction

Retinol dehydrogenase (13-cis,NADH)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Glucuronidated compound transport

Fatty-acyl-ACP hydrolase

Transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Diacylglycerol phosphate kinase (cho)

Acetyl-CoA carboxylase

S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

Citrulline mitochondrial transport via proton antiport

Retinal dehydrogenase (NADPH)

Fumarylacetoacetase

6 phosphofructo 2 kinase

Fatty acyl ACP hydrolase

Bicarbonate transport (HCl/NaHCO3 exchange) (2 HCO3)

Glycolysis / Glyconeogenesis EC:2.7.1.1

Nucleoside triphosphate pyrophosphorylase (dctp)

Selenocysteine lyase

Steroid sulfotransferase

Mannose 1 phosphate guanylyltransferase

Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

Transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

1-alpha hydroxylation of 25-hydroxy vitamin D

Estrogen sulfotransferase

L-lactate dehydrogenase

L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11

Palmitoyl Coenzyme A Hydrolase

Transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Folylpolyglutamate synthetase (DHF)

Acetol monooxygenase

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Fatty-acid-CoA thioesterase (octadecenoate)

NADPH:Quinone Reductase

Ornithine mitochondrial transport via proton antiport

Virtual reaction/potential definition

BIOMASS_cho_producing

Biomass for a producing cell line

Methionine synthase

Transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (CHO)

17-beta-D-glucuronide transport (ATP-dependent)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Retinal dehydrogenase (NADPH)

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Ornithine mitochondrial transport exchange with citruline

Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

Alcohol dehydrogenase (D-1,2-propanediol)

Nucleotide phosphatase

Palmitoyl Coenzyme A Hydrolase

Transport of phytanoylcoa from cytosol to peroxisomes.

Phenylalanine mitochondrial transport via proton symport

Transport of L-Ascorbate by SVCT1 or SVCT2 transporter

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Insosine kinase

Deoxyadenosine kinase

Glycogen synthase (ggn -> glygn1)

IMP dehydrogenase

Fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)

1;2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Ornithine Decarboxylase

Folate transport via proton simport

D-proline reversible transport via proton symport

Fatty-acyl-ACP hydrolase

Ammonia transport via proton antiport

N-acetylgalactosamine kinase (ITP)

Acetoacetate mitochondrial transport via H+ symport

Homogentisateoxygen 1 2 oxidoreductase decyclizing

Phospholipase A2

S-Formylglutathione hydralase

Steryl-sulfatase

Nitric Oxide Synthase (NO forming)

Lacaldehyde reductase (S-propane-1,2-diol forming)

Hydroxymethylglutaryl CoA reductase

L-Tryptophan decarboxy-lyase

Fatty-acyl-ACP hydrolase

Formimidoyltransferase cyclodeaminase

Pyruvate kinase(2)

Glycogenin self-glucosylation

Glycolipid 1,2-alpha-D-mannosyltransferase

Dinucleosidetriphosphatase

3',5'-cyclic-nucleotide phosphodiesterase

Aldose reductase (acetol)

3-sulfinopyruvate hydrolase (spotaneous reaction)

Glycolysis / Glyconeogenesis EC:2.7.1.1

Lysine mitochondrial transport via ornithine carrier

Dihydropyrimidinase (5,6-dihydrouracil)

Alanine transport (Na, H coupled)

Cytochrome P450 2C9

Phosphofructokinase

Stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

Proline dehydrogenase

Adenosine deaminase

Phosphatidylinositol-4-phosphate 3-kinase

Steryl-sulfatase

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Cys-Gly transport in via proton symport

Deoxyguanosine kinase

Alcohol dehydrogenase (ethanol, NADP)

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Cytochrome P450 2E1

R group coenzyme a ligase

L-glutamate 5-semialdehyde dehydratase (spontaneous)

2,3-diketo-5-methylthio-1-phosphopentane degradation reaction 2

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Triiodothyronine Sulfotransferase

Alcohol dehydrogenase (L-lactaldehyde)

4-trimethylaminobutyraldehyde dehydrogenase

S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

Glycolysis / Glyconeogenesis EC:2.7.1.1

Guanidinoacetate N-methyltransferase (c)

Phosphatidylinositol 5-kinase

ATP Creatine kinase (c)

5-Hydroxykynurenamine decarboxy-lyase

10-formyltetrahydrofolate:NADP+ oxidoreductase

Glyoxylate oxidase

Hexokinase (D-mannose:ATP)

Aldose reductase

Adenylosuccinate synthase

N acetylglucosamine 6 phosphate synthase

Arabinose reductase

Ribose transport in via proton symporter

GTP cyclohydrolase I

Dihydroxyacetone kinase

Testicular 17-beta-hydroxysteroid dehydrogenase

(S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

Mannose-1-phosphate guanylyltransferase (GDP)

Riboflavin transport out (ATP dependent)

R group coenzyme a ligase

Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD

3-Sulfoalanine carboxy-lyase

Retinol dehydrogenase (all-trans,NADPH)

B-ketoacyl synthetase (palmitate, n-C16:0)

Catechol O-Methyltransferase

Fatty-acid biosynthesis (n-C16:0ACP)

Deoxyribokinase

D-galactose transport via proton symport

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

Pyridoxal kinase

Fatty-acid biosynthesis (n-C14:0ACP)

Phosphatidylinositol 4,5-bisphosphate 3-kinase

Butyrate mitochondrial transport via proton symport, reversible

Transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

DGTP:pyruvate 2-O-phosphotransferase, cytosol

UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)

Glycolysis / Glyconeogenesis EC:2.7.1.1

2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Transport of docosapentenoylcoa into peroxisomes.

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Glycolysis / Glyconeogenesis EC:2.7.1.1

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

CTP synthase (glutamine)

Malonyl-CoA Decarboxylase cytoplasmic

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

B-ureidopropionase

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

Transport of Nicotinate

Dopamine Sulfotransferase

Phosphate mitochondrial transport via proton symport

Dehydro-L-gulonate decarboxylase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Nucleoside-triphosphatase (ITP)

(R)-3-Hydroxybutanoate transport via H+ symport

Na+/K+ exchanging ATPase

Phosphatidylserine flippase

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

Cytochrome P450 2C8

Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

Sphingolipid long chain base kinase sphinganine

ATP-binding Cassette (ABC) TCDB:3.A.1.201.2

FMN adenylyltransferase

Testosterone sulfotransferase

Fatty-acid biosynthesis (n-C18:0ACP)

Carbonyl reductase [NADPH] 1

Glutathione transport into mitochondria

Folylpolyglutamate synthetase

Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

Phosphatidylethanolamine flippase

DATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40

Uridine kinase (GTP:Uridine)

Retinol dehydrogenase (all-trans)

Palmitoyl Coenzyme A Hydrolase

Malate dehydrogenase

Catechol O-Methyltransferase

Selenophosphate synthase

Pyrophasphatase (dephospho-CoA)

Picolinic acid decarboxylase

Asparagine transport (Na, H coupled)

Noradrenaline secretion via secretory vesicle (ATP driven)

L-threonine dehydrogenase

Quinine 3-Monooxygenase

Steryl-sulfatase

Fatty acyl-CoA peroxisomal transport via ABC system (16:0)

Arginine mitochondrial transport via ornithine carrier

ATP-binding Cassette (ABC) TCDB:3.A.1.208.15

Inorganic diphosphatase

Hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

Linoleoyl-CoA, hydrogen-donor:oxygen oxidoreductase

Carbonyl Reductase (NADPH)

Sodium proton antiporter (H:NA is 1:1)

Ethanolamine kinase

Bilirubin beta-diglucuronide transport MDR

ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

Phosphatidylinositol 4-phosphate 5-kinase

Adenosine kinase

UDP-glucuronate glucuronohydrolase

Iodide:hydrogen-peroxide oxidoreductase 2

L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

D sorbitol dehydrogenase D fructose producing

Lactaldehyde dehydrogenase

4HOXPACDOX_NADP

4HOXPACDOX LPAREN NADP RPAREN

Fumarylpyruvate hydrolase

Transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells

Putrescine acetyltransferase

Nucleoside triphosphate pyrophosphorylase (gtp)

Pantetheine-phosphate adenylyltransferase

Spermidine acetyltransferase (N8)

Glycolysis / Glyconeogenesis EC:2.7.1.1

Diamine transaminase

Pyrroline-5-carboxylate reductase(nadh)

Heme oxygenase 1

Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

Phosphoglycerate dehydrogenase

Glycine reversible transport via proton symport

ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

DUTP:uridine 5'-phosphotransferase

Acetate reversible transport via proton symport

D-alanine transport via proton symport

Iron (II) transport

Phosphoribosylglycinamide formyltransferase

Thymidine kinase (ATP:thymidine)

7-Dehydrocholesterol Reductase

FAOXOHMC10DC10c

Fatty acid omega oxidation(w-OHMC10-->DC10)c

Phosphoribosylaminoimidazole synthase

Fatty-acyl-CoA elongation (n-C18:3CoA)

Phosphatidylcholine flippase

D-Glyceraldehyde dehydrogenase

Major Facilitator(MFS) TCDB:2.A.1.13.1

ATP-binding Cassette (ABC) TCDB:3.A.1.208.7

ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

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Universal metabolite ?

h

External database links

KEGG Compound: C00080
CHEBI: CHEBI:10744, CHEBI:13357, CHEBI:15378, CHEBI:5584
SEED Compound: cpd00067
MetaNetX (MNX) Chemical: MNXM1
BioCyc: META:PROTON
Reactome Compound: 1132304, 113529, 1470067, 156540, 163953, 193465, 194688, 2000349, 2872447, 351626, 372511, 374900, 425969, 425978, 425999, 427899, 428040, 428548, 5668577, 70106, 74722
InChI Key: GPRLSGONYQIRFK-UHFFFAOYSA-N
Human Metabolome Database: HMDB59597

Provided by MetaNetX (CC BY 4.0)

Old identifiers

h[c]

h in other models